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1.发明授权公开(公告)号：US09107828B2
公开(公告)日：2015-08-18
申请号：US12245365
申请日：2008-10-03
Applicant: Robert E. Richard
Inventor： Robert E. Richard
CPC classification number: A61K31/78 , A61K9/0019 , A61K9/0024 , A61K9/16 , A61K9/1635 , A61K9/1641 , A61K31/717 , A61K31/765 , A61K31/785
Abstract: In accordance with one aspect of the invention, novel compositions containing injectable particles are provided in which the injectable particles contain at least two polymeric components that differ in composition from one another (e.g., because at least one polymeric component contains a polymer that is not present in another polymeric component).
Abstract translation: 根据本发明的一个方面，提供了含有可注射颗粒的新型组合物，其中可注射颗粒含有至少两种彼此不同组成的聚合物组分（例如，因为至少一种聚合物组分含有不存在的聚合物 在另一种聚合物组分中）。
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公开(公告)号：US08697119B2
公开(公告)日：2014-04-15
申请号：US10894394
申请日：2004-07-19
Applicant: Robert E. Richard , Rudolf Faust
Inventor： Robert E. Richard , Rudolf Faust
IPC: A61K9/70
CPC classification number: A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/00 , C08L53/02
Abstract: The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.
Abstract translation: 本发明涉及包含异丁烯共聚物的医疗装置。 本发明还涉及用于治疗剂递送的生物相容性共聚物材料，其包含负载治疗剂的异丁烯共聚物。 根据本发明的一个方面，提供了一种医疗装置，其包括：（a）基底和（b）至少一个包含共聚物的聚合物层，其设置在基底的全部或一部分上。 共聚物含有一个或多个聚合物链，其中异丁烯和升高的Tg单体（和任选地，其它单体）以随机，周期，统计或梯度分布引入。
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3.发明授权Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species 有权具有聚合物区域的医疗器械具有含有烃和含杂原子的单体物质的共聚物公开(公告)号：US08075906B2
公开(公告)日：2011-12-13
申请号：US11048613
申请日：2005-02-01
Applicant: Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
Inventor： Robert E. Richard , Marlene C. Schwarz , Rudolf Faust
CPC classification number: A61L31/06 , A61L27/16 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/10 , C08L53/00
Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.
Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。 这些聚合物区域又包含一种或多种聚合物，其中至少一种是包含以下物质的共聚物：（a）一种或多种不饱和烃单体物质和（b）一种或多种含杂原子的单体物质。
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公开(公告)号：US07964209B2
公开(公告)日：2011-06-21
申请号：US11005852
申请日：2004-12-07
Applicant: Shrirang V. Ranade , Robert E. Richard , Kinh-Luan (Lenny) D. Dao , Samuel P. Gido , Akinbode Idowu Isaacs-Sodeye
Inventor： Shrirang V. Ranade , Robert E. Richard , Kinh-Luan (Lenny) D. Dao , Samuel P. Gido , Akinbode Idowu Isaacs-Sodeye
CPC classification number: A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
Abstract: The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphase separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices formed from the above techniques.
Abstract translation: 本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。 该方法包括提供包含聚合物组合物的前体区域，所述聚合物组合物包含彼此不混溶的两个或更多个微相分离的聚合物区域，并且通过包括施加包括电场，磁场的取向场的方法形成所述释放区域， 机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。 电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。 此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。 因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。 本发明的其它方面涉及由上述技术形成的医疗装置。
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公开(公告)号：US07939094B2
公开(公告)日：2011-05-10
申请号：US10175526
申请日：2002-06-19
Applicant: Marlene C. Schwarz , Robert E. Richard
Inventor： Marlene C. Schwarz , Robert E. Richard
CPC classification number: A61L31/10 , A61K9/0024 , A61K31/337 , A61L31/16 , A61L2300/602
Abstract: A method is provided for modulating the rate of release of a therapeutic agent from a release region, which constitutes at least a portion of an implantable or insertable medical device and which controls the rate at which the therapeutic is released from the medical device. The method comprises: (a) providing a release region that comprises (i) a therapeutic agent and (ii) polymer composition comprising two or more immiscible phases; and (b) modulating the rate of release of the therapeutic agent by changing the volume that is occupied by at least one of the immiscible polymer phases relative to the total volume of the release region that is formed. The release region can be, for example, a carrier layer, which comprises the therapeutic agent, or a barrier layer, which is disposed over a region that contains the therapeutic agent. In preferred embodiments, the release region is formed by a process comprising: (a) providing a solution comprising (i) a solvent and (ii) the polymer composition; and (b) forming the release region from the solution by removing the solvent from the solution.
Abstract translation: 提供了一种用于调节治疗剂从释放区域的释放速率的方法，该释放区域构成可植入或可插入的医疗装置的至少一部分并且其控制治疗剂从医疗装置释放的速率。 该方法包括：（a）提供释放区，其包含（i）治疗剂和（ii）包含两个或更多个不混溶相的聚合物组合物; 和（b）相对于形成的释放区域的总体积，通过改变至少一个不混溶的聚合物相占据的体积来调节治疗剂的释放速率。 释放区域可以是例如包含治疗剂的载体层或设置在含有治疗剂的区域上的阻挡层。 在优选的实施方案中，通过包括以下方法形成释放区域：（a）提供包含（i）溶剂和（ii）聚合物组合物的溶液; 和（b）通过从溶液中除去溶剂从溶液中形成释放区。
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Patent Agency Ranking
公开(公告)号：US20090169641A1
公开(公告)日：2009-07-02
申请号：US12337400
申请日：2008-12-17
Applicant: Goldi Kaul , Janel L. Lanphere , Robert E. Richard , Steve Keenan
Inventor： Goldi Kaul , Janel L. Lanphere , Robert E. Richard , Steve Keenan
CPC classification number: C08J9/16
Abstract: Disclosed herein are methods that include providing a first particle having pores, the first particle having a first compression test value, and partially cross-linking the first particle to form a second particle having pores, the second particle having a second compression test value that is larger than the first compression test value by 25% or more, where a maximum dimension of the first particle is 5,000 microns or less, and a maximum dimension of the second particle is 5,000 microns or less.
Abstract translation: 本文公开了包括提供具有孔的第一颗粒，第一颗粒具有第一压缩测试值并部分交联第一颗粒以形成具有孔的第二颗粒的方法，第二颗粒具有第二压缩测试值，即第二压缩测试值 大于第一压缩试验值25％以上，其中第一颗粒的最大尺寸为5000微米以下，第二颗粒的最大尺寸为5000微米以下。
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公开(公告)号：US20090169627A1
公开(公告)日：2009-07-02
申请号：US12341433
申请日：2008-12-22
Applicant: Sonali Puri , Robert E. Richard , John E. O'Gara
Inventor： Sonali Puri , Robert E. Richard , John E. O'Gara
IPC: A61K9/10 , A61K9/14 , A61K31/704
CPC classification number: A61K9/0019 , A61K9/5026 , A61K9/5084 , A61K31/704
Abstract: In accordance with one aspect of the invention, injectable particles are provided which comprise (a) a first group of injectable particles comprising first polymeric particles loaded with a first therapeutic agent and (b) a second group of injectable particles comprising second polymeric particles loaded with a second therapeutic agent. The first and second polymeric particles may be the same or different, and the first and second therapeutic agents may be the same or different. Other aspects of the invention pertain to methods of making such particles, to kits that comprise such particles, and to methods of treatment that employ such injectable particles.
Abstract translation: 根据本发明的一个方面，提供了可注射颗粒，其包含（a）第一组可注射颗粒，其包含装载有第一治疗剂的第一聚合物颗粒和（b）第二组可注射颗粒，其包含装载有 第二治疗剂。 第一和第二聚合物颗粒可以相同或不同，并且第一和第二治疗剂可以相同或不同。 本发明的其它方面涉及制备这种颗粒的方法，包括这种颗粒的试剂盒以及使用这种可注射颗粒的处理方法。
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公开(公告)号：US20090138076A1
公开(公告)日：2009-05-28
申请号：US12349563
申请日：2009-01-07
Applicant: Maria Palasis , Wendy Naimark , Robert E. Richard
Inventor： Maria Palasis , Wendy Naimark , Robert E. Richard
CPC classification number: A61L27/34 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L27/54
Abstract: The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices.
Abstract translation: 本发明通常涉及医疗装置，更具体地涉及至少部分可插入或植入患者体内的医疗装置。 医疗装置通常包括（a）治疗剂，更典型地是高分子量治疗剂，和（b）至少一个聚合物层，其通常用于控制治疗剂从医疗装置释放。 本文还公开了制造这种医疗装置的方法。
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公开(公告)号：US20090053276A1
公开(公告)日：2009-02-26
申请号：US12195806
申请日：2008-08-21
Applicant: Robert E. Richard
Inventor： Robert E. Richard
IPC: A61K9/10
CPC classification number: A61K9/0019 , A61K9/10 , A61K9/1635
Abstract: In accordance with one aspect of the invention, injectable compositions are provided, which contain temperature-sensitive hydrogel particles. The hydrogel particles may be provided in dry form, or they may be provided in hydrated form in an aqueous fluid. The temperature-sensitive hydrogel particles may have an upper critical solution temperature (UCST) below normal body temperature, they may have a lower critical solution temperature (LCST) above normal body temperature, or they may have a LCST that changes from below normal body temperature to above normal body temperature after injection into a subject.
Abstract translation: 根据本发明的一个方面，提供了含有温度敏感性水凝胶颗粒的可注射组合物。 水凝胶颗粒可以以干燥形式提供，或者它们可以水合形式提供在水性流体中。 温度敏感的水凝胶颗粒可能具有低于正常体温的上临界溶解温度（UCST），它们可能具有比正常体温更低的临界溶解温度（LCST），或者它们可具有从低于正常体温变化的LCST 注射到受试者后高于正常体温。
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公开(公告)号：US07491234B2
公开(公告)日：2009-02-17
申请号：US10308587
申请日：2002-12-03
Applicant: Maria Palasis , Wendy Naimark , Robert E. Richard
Inventor： Maria Palasis , Wendy Naimark , Robert E. Richard
IPC: A61F2/06
CPC classification number: A61L27/34 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L27/54
Abstract: The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices.
Abstract translation: 本发明通常涉及医疗装置，更具体地涉及至少部分可插入或植入患者体内的医疗装置。 医疗装置通常包括（a）治疗剂，更典型地是高分子量治疗剂，和（b）至少一个聚合物层，其通常用于控制治疗剂从医疗装置释放。 本文还公开了制造这种医疗装置的方法。
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