公开(公告)号：US20240000830A1

公开(公告)日：2024-01-04

申请号：US18330319

申请日：2023-06-06

Applicant: onCour Pharma, Inc.

Inventor： Daniel R. GETTS

IPC: A61K31/78 ,  A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61K31/01 ,  A61K31/74 ,  A61K31/765 ,  G01N33/68 ,  A61P35/00 ,  A61K9/14 ,  A61K31/00 ,  A61K9/16

CPC classification number: A61K31/78 ,  A61K9/0019 ,  A61K39/001 ,  A61K39/39 ,  A61K31/01 ,  A61K31/74 ,  A61K31/765 ,  G01N33/6893 ,  A61P35/00 ,  A61K9/14 ,  A61K39/0005 ,  A61K31/00 ,  A61K9/146 ,  A61K9/1647 ,  G01N2800/7095 ,  A61K2039/55555 ,  Y02A50/30

Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.

公开(公告)号：US09982940B2

公开(公告)日：2018-05-29

申请号：US14420165

申请日：2013-08-09

Applicant: DPX Fine Chemicals Austria GmbH & Co KG

Inventor： Martin Helmut Friedrich Hanbauer ,  Herwig Landschützer

IPC: F26B3/00 ,  A61K31/785 ,  A61K31/78 ,  F26B1/00 ,  C08G73/02 ,  F26B7/00 ,  F26B3/06 ,  F26B5/00 ,  F26B3/08 ,  C08F6/00 ,  C08J3/00 ,  F26B21/14 ,  C08F220/06

CPC classification number: F26B3/00 ,  A61K31/78 ,  A61K31/785 ,  C08F6/008 ,  C08F220/06 ,  C08G73/02 ,  C08J3/00 ,  C08J2333/02 ,  C08J2379/02 ,  F26B1/00 ,  F26B3/06 ,  F26B3/08 ,  F26B5/005 ,  F26B7/00 ,  F26B21/14 ,  F26B2200/08

Abstract: The invention relates to a process for drying a moist polymeric material to obtain a dried polymeric material, comprising the steps of: mixing the moist polymeric material with an aqueous solution of a carbohydrate to afford a mixture of the moist polymeric material with the carbohydrate; and heating and/or filtering the mixture of the moist polymeric material with the carbohydrate to remove an amount of volatiles to obtain a predried polymeric material having a volatiles content VCpre-dried (pre-drying step); fluidizing the pre-dried material in a fluidized bed in order to further remove an amount of volatiles to obtain the dried polymeric material having a volatiles content VCdried (fluidized bed drying step); and withdrawing and collecting the dried polymeric material from the fluidized bed; wherein VCpre-dried is higher than VCdried and the moist polymeric material comprises at least a polymeric material, said polymeric material comprises fluorine permanently bonded to said polymeric material. The invention further relates to a dried polymeric material obtainable by the process of the invention. Furthermore, the invention relates to various uses of the process of the invention as well as to various uses of the dried polymeric materials.

公开(公告)号：US09925211B2

公开(公告)日：2018-03-27

申请号：US14600912

申请日：2015-01-20

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： S. Ananth Karumanchi

IPC: A61K31/74 ,  A61K31/78 ,  A61K31/737

CPC classification number: A61K31/737 ,  A61K31/78

Abstract: The invention features extracorporeal methods for the treatment of a subject having a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia. The invention also features devices used for the extracorporeal treatment of subjects have a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia.

公开(公告)号：US09867847B2

公开(公告)日：2018-01-16

申请号：US15243195

申请日：2016-08-22

Applicant: WELLOSOPHY CORPORATION

Inventor： Richard Davis ,  Lior Sher

IPC: A61K31/78 ,  A61K9/00 ,  A61K9/48 ,  A61K31/198 ,  A61K31/201 ,  A61K33/06 ,  A61K45/06 ,  A23L33/00 ,  A23L33/175 ,  A23L33/25 ,  A61K47/18 ,  C08F120/06

CPC classification number: A61K31/78 ,  A23L33/175 ,  A23L33/25 ,  A23L33/30 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/0056 ,  A61K9/0065 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/198 ,  A61K31/201 ,  A61K33/06 ,  A61K45/06 ,  A61K47/183 ,  C08F120/06 ,  C08F2810/20 ,  A61K2300/00

Abstract: Appetite suppression and weight management achieved through pre-meal ingestion of temporary gastric bulking agents in the form of superabsorbent polymer hydrogels (SAPHs) selected from among a group consisting of crosslinked polycarboxylic acid moieties is described. The preferred compositions and manufacturing methods of ultrapure preparations of ingestible forms; as well as the preferred methods of use, dosage and administration; distribution and delivery of SAPH materials are also described.

公开(公告)号：US20170298297A1

公开(公告)日：2017-10-19

申请号：US15516407

申请日：2015-10-01

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Weifeng LIN ,  Sabrina JAHN

IPC: C11D3/00 ,  C11D3/36 ,  C11D3/22 ,  G02C7/04

CPC classification number: C11D3/0078 ,  A01N25/26 ,  A61K31/78 ,  C11D3/222 ,  C11D3/225 ,  C11D3/365 ,  G02C7/04

Abstract: A method of inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and a method of inhibiting biofilm formation on a surface of a substrate are disclosed herein. The methods comprise comprising contacting the substrate with a composition which comprises liposomes. Further disclosed herein is a composition comprising liposomes, identified for use in inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and/or inhibiting biofilm formation on a surface of a substrate. Further disclosed are articles comprising a substrate and a composition described herein being applied on a surface of the substrate, and a method of treating keratitis in a contact lens-wearing subject, by rinsing and/or immersing a contact lens in a solution comprising liposomes.

公开(公告)号：US20170281669A1

公开(公告)日：2017-10-05

申请号：US15508737

申请日：2015-11-17

Applicant: RECCE LIMITED

Inventor： Graham John Hamilton MELROSE ,  Michele Keryn DILIZIA

IPC: A61K31/77 ,  C08G65/26 ,  A61K9/00

CPC classification number: A61K31/77 ,  A61K9/0053 ,  A61K31/78 ,  A61P31/04 ,  C08F16/34 ,  C08G65/2603 ,  C08G2650/38 ,  C08G2650/58 ,  Y02A50/473

Abstract: A method of treatment of infection in a subject comprising administering to the subject a copolymer comprising an acrolein derived segment or a polyacrolein oligomer segment and a polyalkylene glycol oligomer segment, the copolymer having a molecular weight of no more than 1500 Daltons.

公开(公告)号：US20170266223A1

公开(公告)日：2017-09-21

申请号：US15505262

申请日：2015-08-25

Applicant: DREXEL UNIVERSITY

Inventor： Michele MARCOLONGO ,  Katsiaryna PRUDNIKOVA ,  Lynn S. PENN

IPC: A61K31/78 ,  C08F120/02 ,  A61K45/06

CPC classification number: A61K31/78 ,  A61K38/00 ,  A61K45/06 ,  A61K47/58 ,  C07K17/08 ,  C08F120/02 ,  A61K2300/00

Abstract: The present invention novel methods of preparing biomimetic proteoglycans, such as bottle-brush, chondroitin sulfate-containing, biomimetic proteoglycans. In certain embodiments, the methods of the invention comprise contacting a core polymer comprising at least one acyl chloride group with a GAG comprising a terminal primary amine.

公开(公告)号：US20170258824A1

公开(公告)日：2017-09-14

申请号：US15505589

申请日：2015-08-11

Applicant: PERORA GMBH

Inventor： Dirk VETTER

IPC: A61K31/78 ,  A61K31/745 ,  A61K31/717 ,  A61K31/79 ,  A23L33/00 ,  A61K9/16 ,  A23L33/15 ,  A23L33/17 ,  A23L33/21 ,  A61K31/20 ,  A61K9/00

CPC classification number: A61K31/78 ,  A23L29/20 ,  A23L33/00 ,  A23L33/15 ,  A23L33/17 ,  A23L33/21 ,  A23L33/30 ,  A23V2002/00 ,  A61K9/0065 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/20 ,  A61K31/717 ,  A61K31/745 ,  A61K31/79 ,  G06F19/324 ,  G06F19/3456

Abstract: The invention provides a method of inducing satiety in a subject comprising a step of orally administering a composition comprising an effective amount of a first agent capable of inducing satiety and of a second agent capable of augmenting the satiety-inducing effect of the first agent. Also disclosed are compositions for carrying out the method, and a body weight management system comprising such compositions in combination with a device configured for the collection, storage and/or display of information relating to a subject's response to a predefined therapeutic regimen of orally administering the composition.

公开(公告)号：US09737486B2

公开(公告)日：2017-08-22

申请号：US14194559

申请日：2014-02-28

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Corinne Bright ,  Rachel Bright ,  Eric Churchill ,  Kam W. Leong ,  Daria Mochly-Rosen

IPC: A61K9/14 ,  A61K9/127 ,  A61K9/51 ,  A61K31/765 ,  A61K31/78 ,  A61K45/06

CPC classification number: A61K9/14 ,  A61K9/5138 ,  A61K31/765 ,  A61K31/78 ,  A61K45/06

Abstract: A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.

公开(公告)号：US20170202904A1

公开(公告)日：2017-07-20

申请号：US15467648

申请日：2017-03-23

Applicant: SYNERGY PHARMACEUTICALS, INC.

Inventor： Stephen COMISKEY ,  Rong FENG ,  John FOSS ,  Kunwar SHAILUBHAI

IPC: A61K38/10 ,  A61K9/00 ,  A61K45/06 ,  A61K47/38 ,  A61K47/12

CPC classification number: A61K38/10 ,  A61K9/0053 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1676 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/192 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/765 ,  A61K31/78 ,  A61K38/12 ,  A61K45/06 ,  A61K47/12 ,  A61K47/38 ,  C07K7/08 ,  C07K7/54 ,  C07K7/64 ,  C12Y406/01002 ,  A61K2300/00

Abstract: The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.