公开(公告)号：US20100166820A1

公开(公告)日：2010-07-01

申请号：US12650234

申请日：2009-12-30

Applicant: Mark Boden ,  Marlene C. Schwarz ,  Frederick H. Strickler ,  Rudolf Faust ,  Umaprasana Ojha ,  Tomoya Higashihara

Inventor： Mark Boden ,  Marlene C. Schwarz ,  Frederick H. Strickler ,  Rudolf Faust ,  Umaprasana Ojha ,  Tomoya Higashihara

IPC: A61K9/00 ,  C08G61/00 ,  C08G63/00 ,  C08G64/00 ,  C08G63/08 ,  C08G69/48 ,  C08G79/02 ,  C08G18/00

CPC classification number: C08F299/04 ,  A61L27/165 ,  A61L27/54 ,  A61L27/58 ,  A61L29/041 ,  A61L29/148 ,  A61L29/16 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G18/4266 ,  C08G18/6204 ,  C08G18/7671 ,  C08G63/00 ,  C08G63/06 ,  C08G63/912 ,  C08G64/18 ,  C08G64/42 ,  C08G69/08 ,  C08G2261/126 ,  C08L53/02

Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.

Abstract translation: 本发明涉及具有一个或多个聚异丁烯链段和一个或多个生物可降解聚合物链段的共聚物，制备这种共聚物的方法，含有这种共聚物的医药制品以及制备这种医疗制品的方法。 根据本发明的某些方面，提供了包含多个聚异丁烯链段和多个可生物降解的聚合物链段的共聚物。 根据本发明的某些方面，提供了共聚物，其包含氨基甲酸酯键，脲键，酰胺键，酯键，酸酐键，碳酸酯键，通常描述为“点击”化学键的键，以及两种或更多种类型 这样的联系。

公开(公告)号：US20130281631A1

公开(公告)日：2013-10-24

申请号：US13880063

申请日：2011-10-13

Applicant: Satoshi Nakazawa ,  Mitsuru Ueda ,  Tomoya Higashihara ,  Namiko Fukuzaki

Inventor： Satoshi Nakazawa ,  Mitsuru Ueda ,  Tomoya Higashihara ,  Namiko Fukuzaki

IPC: C08F30/02

CPC classification number: C08F30/02 ,  C08F8/40 ,  C08F14/18 ,  C08F20/22 ,  C08F130/02 ,  C08F230/02

Abstract: A phosphoric acid polymer containing a repeating unit represented by the following formula (1): (wherein, R1 represents a hydrogen atom or methyl, group).

Abstract translation: 含有下述式（1）表示的重复单元的磷酸聚合物（式中，R1表示氢原子或甲基）。

公开(公告)号：US07786217B2

公开(公告)日：2010-08-31

申请号：US11734230

申请日：2007-04-11

Applicant: Rudolf Faust ,  Tomoya Higashihara

Inventor： Rudolf Faust ,  Tomoya Higashihara

IPC: C08F30/04

CPC classification number: C08F295/00 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  C08F297/023 ,  C08L53/00

Abstract: The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from the group consisting of monomers of formula (I): wherein R1, R2, R3, R4, n, p, M, X, and L are defined herein. The present invention also provides methods for making and using (e.g., in articles of manufacture such as medical devices) the copolymers of the present invention.

Abstract translation: 本发明提供了共聚物，其包括对应于至少一种可阳离子聚合的异单烯烃种类的多个结构单元和对应于至少一种选自式（I）的单体的阴离子可聚合单体种类的结构单元， ：其中R1，R2，R3，R4，n，p，M，X和L在本文中定义。 本发明还提供了用于制造和使用（例如在诸如医疗器械的制品中）本发明的共聚物的方法。

公开(公告)号：US20080255330A1

公开(公告)日：2008-10-16

申请号：US11734230

申请日：2007-04-11

Applicant: Rudolf Faust ,  Tomoya Higashihara

Inventor： Rudolf Faust ,  Tomoya Higashihara

IPC: C08F4/46 ,  C08F30/04

CPC classification number: C08F295/00 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  C08F297/023 ,  C08L53/00

Abstract: The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from the group consisting of monomers of formula (I): wherein R1, R2, R3, R4, n, p, M, X, and L are defined herein.The present invention also provides methods for making and using (e.g., in articles of manufacture such as medical devices) the copolymers of the present invention.

Abstract translation: 本发明提供了共聚物，其包括对应于至少一种可阳离子聚合的异单烯烃种类的多个结构单元和对应于至少一种选自式（I）的单体的阴离子可聚合单体种类的结构单元， 其中R 1，R 2，R 3，R 4，n，p，M，X， 和L在本文中定义。 本发明还提供了用于制造和使用（例如在诸如医疗器械的制品中）本发明的共聚物的方法。

公开(公告)号：US08911760B2

公开(公告)日：2014-12-16

申请号：US12650234

申请日：2009-12-30

Applicant: Mark Boden ,  Marlene C. Schwarz ,  Frederick H. Strickler ,  Rudolf Faust ,  Umaprasana Ojha ,  Tomoya Higashihara

Inventor： Mark Boden ,  Marlene C. Schwarz ,  Frederick H. Strickler ,  Rudolf Faust ,  Umaprasana Ojha ,  Tomoya Higashihara

IPC: A61F13/00 ,  A61K31/74 ,  C08G63/91 ,  C08L67/00 ,  C08G79/02 ,  C08G63/02 ,  C08G63/08 ,  C08G64/00 ,  C08G64/18 ,  A61L27/16 ,  A61L27/54 ,  A61L27/58 ,  A61L29/04 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08G18/42 ,  C08G18/62 ,  C08G18/76 ,  C08G63/00 ,  C08G63/06 ,  C08G64/42 ,  C08G69/08

CPC classification number: C08F299/04 ,  A61L27/165 ,  A61L27/54 ,  A61L27/58 ,  A61L29/041 ,  A61L29/148 ,  A61L29/16 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G18/4266 ,  C08G18/6204 ,  C08G18/7671 ,  C08G63/00 ,  C08G63/06 ,  C08G63/912 ,  C08G64/18 ,  C08G64/42 ,  C08G69/08 ,  C08G2261/126 ,  C08L53/02

Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.

Abstract translation: 本发明涉及具有一个或多个聚异丁烯链段和一个或多个生物可降解聚合物链段的共聚物，制备这种共聚物的方法，含有这种共聚物的医药制品，以及制备这种医疗制品的方法。 根据本发明的某些方面，提供了包含多个聚异丁烯链段和多个可生物降解的聚合物链段的共聚物。 根据本发明的某些方面，提供了共聚物，其包含氨基甲酸酯键，脲键，酰胺键，酯键，酸酐键，碳酸酯键，通常描述为“点击”化学键的键，以及两种或更多种类型 这样的联系。