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    Porous Materials for Biological Sample Collection
    2.
    发明申请
    Porous Materials for Biological Sample Collection 有权
    用于生物样品收集的多孔材料

    公开(公告)号：US20120034601A1

    公开(公告)日：2012-02-09

    申请号：US13121031

    申请日：2009-08-14

    申请人： Frederic Zenhausern ,  Ralf Lenigk ,  James Kinder ,  Jianing Yang

    发明人： Frederic Zenhausern ,  Ralf Lenigk ,  James Kinder ,  Jianing Yang

    IPC分类号： C12Q1/68 ,  C08F283/12 ,  B01D15/08 ,  G01N33/50 ,  C12M1/00

    CPC分类号： G01N1/12 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

    摘要： Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous material in the liquid medium to form a separated sample, and collecting the separated sample in the medium.

    摘要翻译： 用于使用包括有机材料和无机材料的混合多孔材料收集样品的方法，装置和系统。 用于样品收集的方法包括将杂化多孔材料和生物样品接触到多孔材料。 混合多孔材料包括无机材料和有机材料。 该方法包括将附着的样品的多孔材料放置在液体介质中，其中将样品与液体介质中的多孔材料分离以形成分离的样品，并将分离的样品收集在培养基中。

    ANALYSIS
    3.
    发明申请
    ANALYSIS 审中-公开
    分析

    公开(公告)号：US20100241358A1

    公开(公告)日：2010-09-23

    申请号：US12558244

    申请日：2009-09-11

    申请人： Frederic Zenhausern ,  Ralf Lenigk ,  Andrew Hopwood ,  Pieris Koumi

    发明人： Frederic Zenhausern ,  Ralf Lenigk ,  Andrew Hopwood ,  Pieris Koumi

    IPC分类号： G06F19/00 ,  G01N33/48

    CPC分类号： G01N1/28 ,  B01L3/502753 ,  B01L2300/024 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q2600/166 ,  G01D21/00 ,  G01N27/44791 ,  G01N33/487 ,  G01N33/6803 ,  G01N2030/045 ,  G06F17/00

    摘要： A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.

    摘要翻译： 提供了一种验证在核酸分析方法中使用的由多个尺寸标准元素形成的尺寸标准的性能的方法。 通过将尺寸标准引入分析阶段并根据尺寸标准执行基于尺寸的分离来实现验证。 基于尺寸的分离定义了每个尺寸标准元素的实验位置。 比较尺寸标准元件的实验位置是否对应于预期位置。 该比较允许决定是否使用尺寸标准，这取决于尺寸标准件的实验位置是否与预期位置相对应。

    Method for monitoring molecular species within a medium
    4.
    发明授权
    Method for monitoring molecular species within a medium 有权
    监测介质中分子物种的方法

    公开(公告)号：US07097973B1

    公开(公告)日：2006-08-29

    申请号：US09332659

    申请日：1999-06-14

    申请人： Frederic Zenhausern

    发明人： Frederic Zenhausern

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  G01N21/00 ,  C12M1/34

    CPC分类号： G01N21/6486 ,  C12Q1/686 ,  G06F19/24 ,  Y10S977/924 ,  C12Q2561/113

    摘要： Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing. Biological compounds such as nucleotides and polynucleotides can be detected and analyzed. A reaction process such as an accumulation cycle of nucleic acids can be monitored, analyzed, and controlled using a multisensor array (MSA) and multivariate processing. Monitoring a biomolecule includes interrogating the medium, and preferably its gas phase, by coupling a sensor responsive to any changes of the medium and or biomolecule and its secondary products when, for example, an amplification reaction is proceeded. It is also a scope of the present invention to use direct detection and monitoring of biomolecular reactions in real-time without radioactive or fluorescent labeling. A preferred application is real-time polymerase chain reaction (PCR) detection.

    摘要翻译： 使用多传感器阵列（MSA）和多变量处理在介质内监测，分析和/或区分分子种类，优选生物分子的装置和方法。 可以检测和分析生物化合物如核苷酸和多核苷酸。 可以使用多传感器阵列（MSA）和多变量处理来监测，分析和控制反应过程，例如核酸的累积循环。 监测生物分子包括当例如进行扩增反应时，响应于介质和/或生物分子及其次级产物的任何变化而耦合传感器来询问介质，优选其气相。 本发明的范围也是实时地直接检测和监测生物分子反应而没有放射性或荧光标记。 优选的应用是实时聚合酶链反应（PCR）检测。

    Single molecule detection of bio-agents using the F1-ATPase biomolecular motor
    5.
    发明授权
    Single molecule detection of bio-agents using the F1-ATPase biomolecular motor 有权
    使用F1-ATPase生物分子运动的单分子检测生物试剂

    公开(公告)号：US06989235B2

    公开(公告)日：2006-01-24

    申请号：US10365378

    申请日：2003-02-11

    申请人： Lars Chapsky ,  Wayne D. Frasch ,  Chia Fu Chou ,  Frederic Zenhausern ,  Herbert Goronkin

    发明人： Lars Chapsky ,  Wayne D. Frasch ,  Chia Fu Chou ,  Frederic Zenhausern ,  Herbert Goronkin

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： B82Y5/00 ,  C12Q1/6825 ,  C12Q2563/155

    摘要： An exemplary system and method of employing DNA hybridization for the detection of bio-agents is disclosed as comprising inter alia a biomolecular rotary motor (150); a capture probe DNA fragment (140) effectively attached to said biomolecular motor (150); a target DNA fragment (130) suitably adapted for hybridization with said capture probe DNA (140); a signal probe DNA fragment (120) suitably adapted for hybridization with said target DNA (130); and a fluorescent bead (100) attached to said signal probe DNA (120). Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve certain device fabrication parameters and/or performance metrics.

    摘要翻译： 公开了使用DNA杂交来检测生物试剂的示例性系统和方法，其特别包括生物分子旋转马达（150）; 有效连接到所述生物分子马达（150）的捕获探针DNA片段（140）; 适于与所述捕获探针DNA（140）杂交的靶DNA片段（130）; 适于与所述靶DNA（130）杂交的信号探针DNA片段（120）; 和连接到所述信号探针DNA（120）上的荧光珠（100）。 公开的特征和规范可以被不同地控制，适应或以其他方式任意地修改以改进某些设备制造参数和/或性能度量。

    Interferometric measuring method based on multi-pole sensing
    6.
    发明授权
    Interferometric measuring method based on multi-pole sensing 失效
    基于多极感测的干涉测量方法

    公开(公告)号：US5623339A

    公开(公告)日：1997-04-22

    申请号：US511579

    申请日：1995-08-04

    申请人： Hemantha K. Wickramasinghe ,  Frederic Zenhausern ,  Martin P. O'Boyle

    发明人： Hemantha K. Wickramasinghe ,  Frederic Zenhausern ,  Martin P. O'Boyle

    IPC分类号： G01R33/12 ,  G01N37/00 ,  G01Q60/18 ,  G01Q80/00 ,  G01B9/02

    CPC分类号： G01Q60/22 ,  B82Y20/00 ,  B82Y35/00

    摘要： A method for deriving physical properties of a workpiece. The method comprises the steps of sampling an electromagnetic wave packet representative of workpiece properties and comprising encoded scattered wave information derivable from a multi-pole interactive coupling between a probe tip and the workpiece; decoding said electromagnetic wave packet by interrogating at least one of its phase and amplitude information; and, correlating this information to referent physical-chemical properties of the workpiece.

    摘要翻译： 用于导出工件的物理性质的方法。 该方法包括以下步骤：对表示工件属性的电磁波包进行采样，并包括可从探针尖端和工件之间的多极交互耦合导出的编码散射波信息; 通过询问其相位和幅度信息中的至少一个来解码所述电磁波分组; 并将该信息与工件的物理化学特性相关联。

    METHODS AND SYSTEMS FOR PREDICTIVE DESIGN OF STRUCTURES BASED ON ORGANIC MODELS
    9.
    发明申请
    METHODS AND SYSTEMS FOR PREDICTIVE DESIGN OF STRUCTURES BASED ON ORGANIC MODELS 审中-公开
    基于有机模型的结构预测设计方法与系统

    公开(公告)号：US20110287524A1

    公开(公告)日：2011-11-24

    申请号：US13097030

    申请日：2011-04-28

    申请人： Frederic Zenhausern

    发明人： Frederic Zenhausern

    IPC分类号： C12N1/12 ,  C08G77/00 ,  G06F17/50

    CPC分类号： G16B20/00 ,  G16B25/00 ,  G16B40/00

    摘要： A method and system to predict a design of an article of manufacture, which can include the steps of introducing a biological organism into a test environment to activate at least one molecular component of the biological organism representing at least one set of genetic characters of the biological organism; monitoring for change in at least one expression phenomenon pattern in response to the test environment; translating the monitored change in the at least one expression phenomenon pattern into a molecular data profile; interrogating the molecular data profile against a stored database to generate an information pattern of a phenotype correlated to the molecular data profile; and translating the information pattern of the phenotype into a correlated design component of the article of manufacture.

    摘要翻译： 一种用于预测制品的设计的方法和系统，其可以包括以下步骤：将生物体引入到测试环境中以激活生物生物体的至少一个分子成分，代表生物体的至少一组遗传特征 生物; 监测响应于测试环境的至少一种表情现象模式的变化; 将所述至少一种表达现象模式中所监测的变化转化为分子数据谱; 对存储的数据库询问分子数据概况，以产生与分子数据轮廓相关的表型的信息模式; 以及将所述表型的信息模式转换成所述制品的相关设计组件。