Abstract:
A nitrogen test kit for determining the relative level of nitrogen of a user who is involved in a health program where diet and exercise are monitored and adjusted for optimizing physical development, the kit including a plastic stick having a reagent zone on which is included a reactant such as urease, and a pH indicator such as bromthymol blue, used in conjunction with color chart blocks representing a range of urea nitrogen concentrations, wherein the user's urine nitrogen content can be determined by comparing the altered color of the reagent zone of an exposed test strip to the color chart and compared with a personal baseline level, developed from a number of tests under controlled conditions, for determining the present protein nitrogen turnover and approximate balance.
Abstract:
Test means, method for making same and method for assaying the urea content of fluids such as blood serum, plasma, urine and spinal fluid are disclosed. The preferred method for making the test means involves a three stage application of reagents separated from each other on an acid modified carrier matrix. One reagent is o-phthalaldehyde and the other reagent is 3-hydroxy-1,2,3,4-tetrahydrobenzo[h] quinoline, 3-acetoxy-1,2,3,4-tetrahydrobenzo[h]quinoline or their dihydrochloride salts. Stability of the reagents is achieved and precipitation of serum proteins is avoided. Moreover, the interfering color due to the presence of bilirubin is minimized when the urea content of serum is determined.
Abstract:
Urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
Abstract:
Urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
Abstract:
A urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
Abstract:
An improved means and method for the determination of blood urea nitrogen in blood serum or plasma. In brief, the means comprises a novel kit, particularly adapted to present a fresh reagent solution of diacetyl, thiosemicarbazide and anhydrous ethylene glycol in individual vessels for analysis and control procedures. The kit is particularly advantageous in that it permits the fresh preparation of reagents in predetermined volumes, for the determination of blood urea nitrogen. The method of the invention comprises employing the kit of the invention for the analysis of unknown specimens of blood serum or plasma.
Abstract:
A colorimetric reagent and method for the determination of blood urea. The method involves the addition of a small amount of serum to a reagent containing p-dimethylaminobenzaldehyde in acidic dimethylformamide and immediately measuring the increase in absorbance at 450 nm. The increase in absorbance is directly proportional to the urea concentration. The response is sensitive, requires no heating, and is linear up to 125 mg percent of urea nitrogen.
Abstract:
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
Abstract:
Provided herein are methods of employing pharmacodynamics regimens to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects, such as but not limited to calcineurin inhibitor nephrotoxicity. Also provided are methods of assessments of renal functions and/or conditions, and corresponding protocols to modify, stop, restore and/or re-initiate voclosporin dosing and administrations to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects.