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    Fluoroalkanesulfonyl azide copolymers
    73.
    发明授权
    Fluoroalkanesulfonyl azide copolymers 有权
    氟烷基磺酰叠氮化物共聚物

    公开(公告)号：US06365693B1

    公开(公告)日：2002-04-02

    申请号：US09553165

    申请日：2000-04-19

    Applicant: Ming-Hong Hung

    Inventor： Ming-Hong Hung

    IPC: C08F22802

    CPC classification number: C08F228/02 ,  C07C311/49 ,  C08F214/184 ,  C08F214/262 ,  C08F216/1466

    Abstract: Fluorinated olefins and fluorinated vinyl ethers, each having sulfonyl azide groups, are useful monomers in preparing fluoropolymers having functional side groups. Such functional side groups are useful in curing the fluoropolymers and also for enhancing the adhesion of the fluoropolymers to other substrates.

    Abstract translation: 各自具有磺酰基叠氮基的氟化烯烃和氟化乙烯基醚是制备具有官能侧基的含氟聚合物的有用单体。 这样的官能侧基可用于固化含氟聚合物，也可用于增强含氟聚合物与其它基材的粘合性。

    Hydrazine derivatives
    74.
    发明授权
    Hydrazine derivatives 失效
    肼衍生物

    公开(公告)号：US06265446B1

    公开(公告)日：2001-07-24

    申请号：US09444861

    申请日：1999-11-22

    Applicant: Michael John Broadhurst ,  William Henry Johnson ,  Daryl Simon Walter

    Inventor： Michael John Broadhurst ,  William Henry Johnson ,  Daryl Simon Walter

    IPC: A61K3118

    CPC classification number: C07D295/088 ,  C07C311/49 ,  C07D213/34 ,  Y10S514/824 ,  Y10S514/863

    Abstract: Hydrazine derivatives of the formula wherein R1 represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl, R2 represents heterocyclyl or NR5R6, R3 represents hydrogen, lower alkyl, halo-lower alkyl, cyano-lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, lower alkoxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, heterocyclyl-lower alkyl, heterocyclylcarbonyl-lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, heteroaryl or aryl-lower alkyl, R4 represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl or a grouping of the formula -Z-aryl, -Z-heterocyclyl or —(CH2)n—, CH═CR7R8, R5 and R6 each independently represent hydrogen or lower alkyl, R7 and R8 each independently represent hydrogen or lower alkyl or R7 and R8 together represent lower alkylene in which one CH2 group is optionally replaced by a hetero atom, X and Z each represent a spacer group, and n stands for 0, 1 or 2, and their pharmaceutically acceptable salts thereof, inhibit the release of tumor necrosis factor alpha (TNF-&agr;) from cells. They can be used as medicaments, especially in the treatment of inflammatory and autoimmune diseases, osteoarthritis, respiratory diseases, tumors, cachexia, cardiovascular diseases, fever, haemorrhage and sepsis.

    Abstract translation: 式中R 1的肼衍生物代表低级烷基，低级链烯基，低级环烷基，低级环烷基 - 低级烷基，芳基或芳基 - 低级烷基，R2代表杂环基或NR5R6，R3代表氢，低级烷基，卤代低级烷基，氰基低级 烷基，羟基 - 低级烷基，氨基 - 低级烷基，低级烷氧基 - 低级烷基，低级烷氧基羰基 - 低级烷基，低级环烷基 - 低级烷基，芳基 - 低级烷基，杂环基 - 低级烷基，杂环基羰基 - 低级烷基，低级烯基， ，低级环烷基，芳基，杂芳基或芳基 - 低级烷基，R4代表低级烷基，低级烯基，低级环烷基，低级环烷基 - 低级烷基或式-Z-芳基，-Z-杂环基或 - （CH2）n - ，CH = CR 7 R 8，R 5和R 6各自独立地表示氢或低级烷基，R 7和R 8各自独立地表示氢或低级烷基，或者R 7和R 8一起表示低级亚烷基，其中一个CH 2基团任选地被杂原子X， Z各自表示间隔物 并且n代表0,1或2及其药学上可接受的盐，从细胞中抑制肿瘤坏死因子α（TNF-α）的释放。 它们可以用作药物，特别是用于治疗炎性和自身免疫性疾病，骨关节炎，呼吸系统疾病，肿瘤，恶病质，心血管疾病，发烧，出血和败血症。

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