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    Process for preparing .beta.-lactam derivative and synthetic intermediate thereof
    1.
    发明授权
    Process for preparing .beta.-lactam derivative and synthetic intermediate thereof 失效
    制备β-内酰胺衍生物及其合成中间体的方法

    公开(公告)号：US5414081A

    公开(公告)日：1995-05-09

    申请号：US18407

    申请日：1993-02-17

    申请人： Hiroshi Horikawa ,  Kazuhiko Kondo ,  Tameo Iwasaki

    发明人： Hiroshi Horikawa ,  Kazuhiko Kondo ,  Tameo Iwasaki

    IPC分类号： C07D463/00 ,  C07D477/00 ,  C07D477/02 ,  C07D477/04 ,  C07D499/06 ,  C07D499/88 ,  C07D499/893 ,  C07D499/897 ,  C07D501/16 ,  C07D501/18 ,  C07D503/04 ,  C07D505/00 ,  C07D513/04 ,  C07D515/04 ,  C07D487/04

    CPC分类号： C07D513/04 ,  C07D477/02 ,  C07D477/04 ,  C07D515/04

    摘要： Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group, or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.

    摘要翻译： 公开了一种制备由下式表示的β-内酰胺化合物的方法：低级烷基或各自可被保护的氨基; R2表示氢原子或酯残基; X表示可以被低级烷基，硫原子或由下式表示的基团取代的亚甲基：-A-CH2-，其中A表示硫原子，氧原子或亚甲基; W表示羟基的活性酯残基或其盐，其包括如下步骤：处理由下式表示的1-氮杂-3-硫杂 - 双环烷烃化合物：其中R1，R2和X 具有与上述相同的含义，或其盐与脱碱剂存在下的碱，然后使所得化合物与羟基的活性酯化剂反应。

    Process for preparing .beta.-lactam derivative and synthetic intermediate
    2.
    发明授权
    Process for preparing .beta.-lactam derivative and synthetic intermediate 失效
    制备β-内酰胺衍生物和合成中间体的方法

    公开(公告)号：US5589592A

    公开(公告)日：1996-12-31

    申请号：US393395

    申请日：1995-04-07

    申请人： Hiroshi Horikawa ,  Kazuhiko Kondo

    发明人： Hiroshi Horikawa ,  Kazuhiko Kondo

    IPC分类号： C07D463/00 ,  C07D477/00 ,  C07D477/02 ,  C07D477/04 ,  C07D499/06 ,  C07D499/88 ,  C07D499/893 ,  C07D499/897 ,  C07D501/16 ,  C07D501/18 ,  C07D503/04 ,  C07D505/00 ,  C07D513/04 ,  C07D515/04

    CPC分类号： C07D513/04 ,  C07D477/02 ,  C07D477/04 ,  C07D515/04

    摘要： Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group,or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.

    摘要翻译： 公开了一种制备由下式表示的β-内酰胺化合物的方法：其中R 1表示羟基取代的低级烷基或各自可被保护的氨基; R2表示氢原子或酯残基; X表示可以被低级烷基，硫原子或由下式表示的基团取代的亚甲基：-A-CH2-，其中A表示硫原子，氧原子或亚甲基; W表示羟基的活性酯残基或其盐，其包括如下步骤：处理由下式表示的1-氮杂-3-硫杂 - 双环烷烃化合物：其中R1，R2和X 具有与上述相同的含义，或其盐与脱碱剂存在下的碱，然后使所得化合物与羟基的活性酯化剂反应。