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    Method for making aromatic ether anhydrides and products made thereby
    1.
    发明授权
    Method for making aromatic ether anhydrides and products made thereby 失效
    制造芳香族醚类和其制品的方法

    公开(公告)号：US3850965A

    公开(公告)日：1974-11-26

    申请号：US34647273

    申请日：1973-03-30

    申请人： GEN ELECTRIC

    发明人： WILLIAMS F

    IPC分类号： C07C51/567 ,  C07D307/89 ,  C08G59/42 ,  C07D7/18

    CPC分类号： C08G59/4223 ,  C07C51/567 ,  C07D307/89 ,  C07C65/24 ,  C07C65/21

    摘要： 1. A METHOD FOR MAKING AROMATIC ETHER ANHYDRIDES OF THE FORMULAS,



    1,3-DI(O=),(R-X-)-1H,3H-NAPHTHO(1,8-CD)-PYRAN

    WHICH COMPRISES, (1) EFFECTING REACTION BETWEEN AN ALKALI METAL PHENOXIDE OF THE FORMULA

    R-X-M,

    AND A NITRO- OR HALO-SUBSTITUTED AROMATIC ANHYDRIDE SELECTED FROM COMPOUNDS OF THE FORMULAS,

    1,3-DI(O=),Y-PHTHALAN

    1,3-DI(O=),Y-1H,3H-NAPHTHO(1,8-CD)-PYRAN
    WHERE Y CAN BE NITRO, CHLORO, FLUORO, BROMO, OR IODO, (2) AND RECOVERING FROM THE RESULTING MIXTURE OF (1), AN AROMATIC ETHER ANHYDRIDE, WHERE M IS AN ION OF AN ALKALI METAL SELECTED FROM SODIUM, POTASSIUM, LITHIUM AND RUBIDIUM, AND R IS AN AROMATIC RADICAL HAVING FROM 6-13 CARBON ATOMS SELECTED FROM THE CLASS CONSISTING OF PHENYL, TOLYL, XYLYL, NAPHTHYL, ANTHRYL, AND HALOGENATED DERIVATES THEREOF, AND X IS A DIVALENT RADICAL SELECTED FROM -S- AND -O-.
    1,3-DI(O=),(R-X-)-PHTHALAN

    Carbapenem derivatives
    6.
    发明授权
    Carbapenem derivatives 失效
    卡巴培南衍生物

    公开(公告)号：US6037341A

    公开(公告)日：2000-03-14

    申请号：US765387

    申请日：1996-12-18

    申请人： Nobuaki Sato ,  Manabu Sasho ,  Atsushi Kamata ,  Takaaki Suzuki ,  Isao Sugiyama ,  Kanemasa Katsu ,  Takeshi Suzuki

    发明人： Nobuaki Sato ,  Manabu Sasho ,  Atsushi Kamata ,  Takaaki Suzuki ,  Isao Sugiyama ,  Kanemasa Katsu ,  Takeshi Suzuki

    IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61K31/445 ,  A61P31/04 ,  C07D477/20 ,  C07D7/18

    CPC分类号： C07D477/20 ,  Y02P20/55

    摘要： Compounds having potent antimicrobial effects over Gram-positive bacteria and Gram-negative bacteria, a high stability to .beta.-lactamases and DHP-I and a high safety for the human body and a process for producing the same. Carbapenem compounds represented by the following general formula (I) or salts thereof: ##STR1## wherein the ring A represents a 3- to 7-membered non-aromatic ring containing at least one nitrogen atom and optionally having a substituent other than R.sup.6 ; R.sup.1 represents hydrogen or methyl; R.sup.2 and R.sup.5 are the same or different and each represents hydrogen or a protecting group of the hydroxyl group; R.sup.3 represents hydrogen or a protecting group of the carboxyl group; R.sup.4 represents hydrogen, lower alkyl or a protecting group of the amino group; R.sup.6 represents: (1) hydrogen, (2) lower alkyl, optionally substituted by an optionally protected hydroxy, carbamoyl, formimidoyl, acetimidoyl or ##STR2## wherein R.sup.7 and R.sup.8 are the same or different and each represents hydrogen, lower alkyl, or a protecting group of the amino group), or (3) a protecting group of the amino group or a protecting group of the imino group; and m is 0 or 1. These compounds have antimicrobial effects and are useful as a drug.

    摘要翻译： PCT No.PCT / JP95 / 01233 Sec。 371日期：1996年12月18日 102（e）日期1996年12月18日PCT提交1995年6月29日PCT公布。 出版物WO96 / 01261 日期1996年1月18日具有对革兰氏阳性菌和革兰氏阴性菌具有强效抗菌作用的化合物，对β-内酰胺酶和DHP-1的高稳定性和对人体的高安全性及其制备方法。 由以下通式（I）表示的碳青霉烯化合物或其盐：其中环A表示含有至少一个氮原子且任选具有除R6以外的取代基的3-至7-元非芳族环; R1代表氢或甲基; R2和R5相同或不同，各自表示氢或羟基的保护基; R3表示氢或羧基的保护基; R4表示氢，低级烷基或氨基的保护基; R 6表示：（1）氢，（2）任选被任选保护的羟基，氨基甲酰基，亚氨基，亚氨代乙酰基取代的低级烷基，或其中R 7和R 8相同或不同，各自表示氢，低级烷基或保护基 氨基），或（3）氨基的保护基或亚氨基的保护基; 并且m为0或1.这些化合物具有抗微生物作用并且可用作药物。

    3-aminomethyl-1-phenylisochromans and their preparation
    7.
    发明授权
    3-aminomethyl-1-phenylisochromans and their preparation 失效
    3-氨基-1-苯并吡喃酮及其制备方法

    公开(公告)号：US3840561A

    公开(公告)日：1974-10-08

    申请号：US17499371

    申请日：1971-08-25

    申请人： RIKER LABORATORIES INC

    发明人： PETRACEK F ,  SUGISASKA N

    IPC分类号： C07D7/18

    摘要： 1. PROCESS FOR PRODUCTION OF A 3-AMINOMETHYL-1-PHENYLISOCHROMAN WHICH COMPRISES CONVERTING A 1-PHENYL-3-ISOCHROMANCARBOXYLIC ACID TO THE CORRESPONDING CARBOXYLIC ACID CHLORIDE OR BROMIDE, REACTING THE HALIDE THUS FORMED WITH AMMOIA, A PRIMARY OR SECONDARY AMINE HAVING FROM 1 TO 12 CARBON ATOMS TO FORM THE CORRESPONDING CARBOXYLIC ACID AMIDE, AND REDUCING THE CARBONYL GROUP OF THE AMIDE

    4-methylen-2-oxa-3-keto androstanes and 4-methyl-delta4 derivatives thereof
    9.
    发明授权
    4-methylen-2-oxa-3-keto androstanes and 4-methyl-delta4 derivatives thereof 失效
    4-甲基-2-氧代-3-酮乙醇胺和4-甲基-3,6-二脱氧-4-苯并吡喃衍生物

    公开(公告)号：US3716559A

    公开(公告)日：1973-02-13

    申请号：US3716559D

    申请日：1971-07-13

    申请人： SEARLE & CO

    发明人： CHORVAT R ,  PAPPO R

    IPC分类号： C07J73/00 ,  C07D7/18

    CPC分类号： C07J73/003

    摘要： THE REACTION OF 2-OXA-3-KETO ANDROSTANES WITH FORMALDEHYDE AFFORDS THE CORRESPONDING 4-METHYLENE DERIVATIVES, WHICH ARE REARRANGED BY TREATMENT WITH PALLADIUM CATALYST TO AFFORD THE CORRESPONDING 4-METHYL-$4 DERIVATIVES. BOTH THE 4-METHYLENE AND 4-METHYL-$4 COMPOUNDS ARE PHARMACOLOGICALLY ACTIVE AS IS EVIDENCE BY THEIR ANABOLIC AND ANDROGENIC PROPERTIES.