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    1{40 -({62 -hydroxyethyl)-1{40 -demethyl clindamycin 2-acylates
    1.
    发明授权
    1{40 -({62 -hydroxyethyl)-1{40 -demethyl clindamycin 2-acylates 失效
    1 {40 - （{62-羟基乙基）-1 {40-甲基苯胺二氰酸酯

    公开(公告)号：US3892730A

    公开(公告)日：1975-07-01

    申请号：US42515073

    申请日：1973-12-17

    申请人： UPJOHN CO

    发明人： BIRKENMEYER ROBERT D

    IPC分类号： C07H15/16 ,  C08B19/00

    CPC分类号： C07H15/16

    摘要： 1''-( Beta -Hydroxyethyl)-1''-demethylclindamycin 2-acylate compounds of the formula:

    OR THE ACID ADDITION SALTS THEREOF WHEREIN Halo is chlorine, bromine, or iodine, X is an acyl radical of an aliphatic carboxylic acid having from 2 to 18 carbon atoms, inclusive; R is alkyl of not more than 4 carbon atoms; and R1 is alkyl of not more than 8 carbon atoms. The compounds have clindamycin-like antibacterial activity and provide particularly high concentrations of compound in the urinary tract thereby being particularly useful in treating bacterial infections of the upper and lower urinary tract as well as L-forms in the kidney.

    摘要翻译： 1' - （β-羟基乙基）-1'-去甲基克林霉素2-酰化物下式的化合物：

    Derivatives of lincomycin and its analogs and process
    2.
    发明授权
    Derivatives of lincomycin and its analogs and process 失效
    LINCOMYCIN的衍生物及其类似物和方法

    公开(公告)号：US3790560A

    公开(公告)日：1974-02-05

    申请号：US3790560D

    申请日：1972-03-22

    申请人： UPJOHN CO

    发明人： BANNISTER B

    IPC分类号： C07H15/16 ,  C08B19/00

    CPC分类号： C07H15/16

    摘要： ALKYL 7-DEXY-7-MERCAPTOALKYLTHIO-A-THIOLINCONSAMINIDES USEFUL AS INTERMEDIATES FOR PREPARING ANTIBACTERIALLY ACTIVE 7-DEOXY-7-MERCAPTOALKYLTHIO-LINCOMYCINS ARE PREPARED BY HEATING ALKYL N-ACYL-6,7-AZIRIDINO-6-DEAMINO-7-DEOXY-ATHIOLINCOSAMINIDES WITH AN APPROPRIATE SULFIDE IN THE PRESENCE OF GLACIAL ACETIC ACID OR OTHER ANHYDROUS LOWER ALKANOIC ACID, OR ANHYDROUS BENZOIC ACID OR OTHER ARENOIC ACID OR NOT MORE THAN 12 CARBON ATOMS.

    Process for preparing soluble flavonoid glycosides
    10.
    发明授权
    Process for preparing soluble flavonoid glycosides 失效
    制备可溶性黄曲霉糖苷的方法

    公开(公告)号：US3878191A

    公开(公告)日：1975-04-15

    申请号：US22425372

    申请日：1972-02-07

    申请人： KYOWA HAKKO KOGYO KK

    发明人： FUKUMOTO JUICHIRO ,  OKADA SHIGETAKA

    IPC分类号： C07H17/07 ,  C12P19/18 ,  C07C15/12 ,  C08B19/00

    CPC分类号： C07H17/07 ,  C12P19/18 ,  Y10S435/839

    摘要： Modified flavonoid glycosides are prepared wherein the molecules include two or more glucose substituents. Such modified flavonoid glycosides exhibit uniquely higher solubilities than the unmodified compounds. Modification is achieved by reacting flavonoid monoglycosides with starchy materials in the presence of Alpha -amylase enzymes. The resultant flavonoid glycosides include principally two or three glucose substituents per molecule. Further reaction of the modified glycosides with Beta -amylase gives rise to decomposition of the glycoside having a high polymerization degree and a flavonoid glycoside having two or three glucoses per molecule is solely obtained.

    摘要翻译： 制备改性黄酮苷，其中分子包括两个或多个葡萄糖取代基。 这种修饰的类黄酮糖苷显示比未改性化合物独特的更高的溶解度。 通过在α-淀粉酶存在下使类黄酮单糖苷与淀粉物质反应来实现改性。 所得到的类黄酮苷每分子主要包括两个或三个葡萄糖取代基。 改性糖苷与β-淀粉酶的进一步反应仅产生具有高聚合度的糖苷的分解，每分子具有两个或三个葡萄糖的类黄酮糖苷。