公开(公告)号：US20180348119A1

公开(公告)日：2018-12-06

申请号：US15994431

申请日：2018-05-31

Applicant: Government of the United States of America, as represented by the Secretary of Commerce

Inventor： Jeeseong C. Hwang ,  Heidrun Wabnitz

IPC: G01N21/25 ,  G01N21/27 ,  G01N33/49 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/00

CPC classification number: G01N21/255 ,  A61B5/14553 ,  A61B5/1495 ,  A61B5/7246 ,  G01N21/27 ,  G01N21/4785 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4925 ,  G01N2021/4797 ,  G01N2201/0675 ,  G01N2201/0683 ,  G01N2201/0893

Abstract: An optical phantom produces a time-resolved diffuse reflectance spectrum and includes: a light source; a spatial light modulator; and an optical delay line including optical fibers of different length that produce different time-of-flight distributions, such that different time-of-flight distributions are combined and produce phantom light having the time-resolved diffuse reflectance spectrum.

公开(公告)号：US20180306716A1

公开(公告)日：2018-10-25

申请号：US15979521

申请日：2018-05-15

Applicant: NxGen Partners IP, LLC

Inventor： Solyman Ashrafi

IPC: G01N21/59 ,  G01N33/68 ,  G01N33/487 ,  A61B5/00 ,  G01N33/483 ,  G01N21/64 ,  G01N21/65 ,  G01N21/3581 ,  G01N21/21

CPC classification number: G01N21/59 ,  A61B5/0075 ,  G01N21/21 ,  G01N21/3581 ,  G01N21/636 ,  G01N21/6486 ,  G01N21/65 ,  G01N33/483 ,  G01N33/487 ,  G01N33/6896 ,  G01N2201/0675 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: An apparatus for detecting a material within a sample includes a light emitting unit for directing at least one light beam through the sample. A plurality of units receive the light beam that has passed through the sample and performs a spectroscopic analysis of the sample based on the received light beam. Each of the plurality of units analyze a different parameter with respect to the sample a provide a separate output signal with respect to the analysis. A processor detects the material with respect each of the provided separate output signals.

公开(公告)号：US20180246307A1

公开(公告)日：2018-08-30

申请号：US15758546

申请日：2016-09-07

Applicant: University of Southampton

Inventor： Edward Thomas Foss ROGERS ,  Peter John Shand SMITH

IPC: G02B21/00 ,  G01N21/21

CPC classification number: G02B21/0068 ,  G01N21/21 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0072 ,  G02B21/0092 ,  G02B27/58

Abstract: A super-resolution scanning confocal polarisation contrast microscope is provided. The microscope has a laser light source (1), sample stage (10) for mounting a sample 6 and detector (8). A polarisation controller (3) is used to set the polarisation state of the light beam to any one of a defined set of different polarisation states. A spatial light modulator (5) modulates the light beam in amplitude and/or phase to focus a sub-diffraction-limit central spot on the sample together with unwanted sidebands. A scanning confocal scheme is used with a pin hole 9 in front of the detector (8) so that only that portion of the light is detected which has comes from the central spot, while rejecting light that has been scattered by the sample from the sidebands. Polarisation contrast images with sub-diffraction limit resolution can thus be acquired.

公开(公告)号：US20170082545A1

公开(公告)日：2017-03-23

申请号：US15275707

申请日：2016-09-26

Applicant: NIKON CORPORATION

Inventor： Fumihiro DAKE ,  Tomoko UJIKE ,  Hiroki YAZAWA

IPC: G01N21/64 ,  G01N21/65 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/6445 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0096

Abstract: A super-resolution observation device includes an illumination optical system collecting a first illuminating light having a first optical frequency co, on a first region of an observation object, collecting a second illuminating light having a second optical frequency ω2′ on a second region partially overlapping the first region, and collecting a third illuminating light having a third optical frequency ω2 on a third region containing a non-overlap region which is a region of the first region and does not overlap the second region; and an extraction unit extracting a signal light generated in accordance with a change in an energy level of a substance in the non-overlap region from a light generated in all of the first region, the second region, and the third region.

公开(公告)号：US20170052430A1

公开(公告)日：2017-02-23

申请号：US15123760

申请日：2015-04-03

Applicant: Sony Corporation

Inventor： Yoshihito Higashitsutsumi ,  Shinichiro Gomi ,  Jun Iwama

IPC: G03B15/06 ,  G02F1/1335 ,  G01N21/21 ,  G02B5/30 ,  H04N5/225 ,  G01B11/30 ,  A61B5/00 ,  G03B15/03

CPC classification number: G03B15/06 ,  A61B5/00 ,  A61B5/0022 ,  A61B5/0077 ,  A61B5/107 ,  A61B5/442 ,  G01B11/303 ,  G01N21/21 ,  G01N2201/0675 ,  G02B5/3083 ,  G02B21/06 ,  G02F1/133528 ,  G03B15/03 ,  G03B15/05 ,  G03B15/14 ,  H04N5/225 ,  H04N5/2256

Abstract: An imaging device includes a camera 31, a light source 32, a polarizer 35 arranged between the camera 31 plus the light source 32 and an object 11, and a spatial light modulator 40A arranged between the polarizer 35 and the object 11 to control a revolution angle of an emitting light polarization plane relative to an incident light polarization plane.

Abstract translation: 成像装置包括相机31，光源32，布置在相机31加上光源32和对象11之间的偏振器35以及布置在偏振器35和物体11之间以控制旋转的空间光调制器40A 发射光偏振面相对入射光偏振面的角度。

公开(公告)号：US20160356746A1

公开(公告)日：2016-12-08

申请号：US14913958

申请日：2014-08-26

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Rafael Piestun ,  Hengyi Ju ,  Jacob Dove ,  Antonio Miguel Caravacca-Aguirre ,  Todd Murray ,  Donald Conkey

IPC: G01N29/24 ,  G01N29/06

CPC classification number: G01N29/2418 ,  A61B5/0095 ,  G01N21/1702 ,  G01N29/0654 ,  G01N2021/1706 ,  G01N2201/0675

Abstract: Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Embodiments of the invention can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.

Abstract translation: 公开了系统和方法来增强散射材料后面，通过或内部的三维光声成像。 本发明的实施例可以在散射体之前使用波前整形来增加超声波换能器焦点中的光能密度和/或增强光强度。 由放置在散射介质后面的物体引起的光声信号可以用作反馈以优化波前，使光声振幅能够提高一个数量级。 使用增强的光强度，可以在二维扫描物体和/或可以在对数据进行后处理以重构图像之前重新优化波阵面来扫描点。 时间光声信号提供重建第三维信息的信息。

公开(公告)号：US09500846B2

公开(公告)日：2016-11-22

申请号：US14660906

申请日：2015-03-17

Applicant: Howard Hughes Medical Institute

Inventor： Robert E. Betzig ,  Kai Wang

IPC: F21V9/16 ,  G01J1/58 ,  G02B21/00 ,  G02B21/36 ,  G01N21/64

CPC classification number: G02B21/0064 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2201/0675 ,  G02B21/0056 ,  G02B21/006 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/361 ,  G02B26/06

Abstract: Excitation light is focused to a focus within a sample and the focus is scanned within a volume in the sample with scanning optical elements. Signal light emitted from the focus is de-scanned, with the one or more scanning optical elements, onto a wavefront sensor as the focus is scanned within the volume. Based on the descanned signal light, an average aberration created by the volume of the sample of a wavefront of the excitation light is determined. A wavefront of the excitation light is corrected by an amount according to the determined average aberration while the focus is scanned within the volume, the signal light is imaged onto a photosensitive detector as the focus is scanned within the volume, and a wavefront of the imaged signal light is corrected by an amount according to the determined average aberration while the focus is scanned. These steps can be repeated for a plurality of different volumes in the sample, and an image of the sample can be generated based on the detected signal light from scanned foci within the different volumes.

Abstract translation: 激发光聚焦到样品中的焦点，并用扫描光学元件在样品中的体积内扫描焦点。 当聚焦在体积内被扫描时，从焦点发出的信号光与一个或多个扫描光学元件一起被扫描到波前传感器上。 基于下拉信号光，确定由激发光的波前的样本的体积产生的平均像差。 当在体积内扫描焦点时，根据确定的平均像差校正激发光的波前，当体积内的焦点被扫描时，将信号光成像到光敏检测器上，并且成像的波前 当扫描焦点时，根据确定的平均像差校正信号光的量。 可以对样本中的多个不同体积重复这些步骤，并且可以基于来自不同体积内的扫描焦点的检测到的信号光来生成样本的图像。

公开(公告)号：US09285575B2

公开(公告)日：2016-03-15

申请号：US12690579

申请日：2010-01-20

Applicant: Xiaoliang Sunney Xie ,  Christian Freudiger ,  Wei Min

Inventor： Xiaoliang Sunney Xie ,  Christian Freudiger ,  Wei Min

IPC: G02B21/00 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G02B21/08 ,  G01J3/12

CPC classification number: G02B21/002 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/1282 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/0675 ,  G02B21/082

Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-linear interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.

Abstract translation: 公开了一种显微镜成像系统，其包括光源系统，光谱整形器，调制器系统，光学系统，光学检测器和处理器。 光源系统用于提供第一脉冲串和第二脉冲串。 频谱整形器用于频谱修改频率分量的宽带范围的至少一些频率分量的光学特性，使得频率分量的宽带范围成形，产生成形的第一脉冲串，从而特别地探测来自 样本，并从样本中不感兴趣的特征中减少信息。 调制器系统用于以调制频率调制成形的第一脉冲序列和第二脉冲串中的至少一个的性质。 光学检测器用于检测通过公共焦点体积传输或反射的感兴趣的脉冲串的基本上所有的光学频率分量的积分强度。 处理器用于检测由于成形的第一脉冲序列与第二脉冲串的非线性相互作用而导致的感兴趣的脉冲串的基本上所有的光学频率分量的积分强度的调制频率的调制 在公共焦点体积中调制，并且为显微镜成像系统提供用于图像的像素的输出信号。

公开(公告)号：US20150177502A1

公开(公告)日：2015-06-25

申请号：US14580133

申请日：2014-12-22

Applicant: OLYMPUS CORPORATION

Inventor： Yasunari MATSUKAWA

IPC: G02B21/00 ,  G02F1/13 ,  G02F1/11 ,  G01N21/64 ,  G02F1/133

CPC classification number: G02B21/0032 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B21/0076 ,  G02B21/16

Abstract: To avoid unstable light radiation during switching of a phase modulation amount and stimulate desired stimulation points simultaneously, provided is a photo-stimulator which includes an AOM switching on/off of radiation of stimulation light to a specimen S; an LCOS-SLM being capable of modulating a phase of stimulation light once radiation to the specimen S has been turned on by the AOM; and a controller controlling the LCOS-SLM to switch a phase modulation amount of stimulation light and controlling the AOM to switch on/off of radiation of stimulation light, wherein the controller causes the AOM to turn off radiation of stimulation light before the LCOS-SLM starts switching a phase modulation amount, and causes the AOM to turn on radiation of stimulation light after the LCOS-SLM completes switching a phase modulation amount.

Abstract translation: 为了在切换相位调制量期间避免不稳定的光辐射并且同时刺激所需的刺激点，提供了一种光刺激器，其包括AOM将刺激光的辐射切换到样本S; 能够通过AOM打开辐射至样本S的能够调制刺激光的相位的LCOS-SLM; 以及控制器，控制LCOS-SLM以切换刺激光的相位调制量并控制AOM以打开/关闭刺激光的辐射，其中控制器使AOM在LCOS-SLM之前关闭刺激光的辐射 开始切换相位调制量，并且在LCOS-SLM完成切换相位调制量之后使得AOM打开刺激光的辐射。

公开(公告)号：US09019503B2

公开(公告)日：2015-04-28

申请号：US14021822

申请日：2013-09-09

Applicant: Bing Ouyang ,  Fraser Dalgleish ,  Anni Dalgleish

Inventor： Bing Ouyang ,  Fraser Dalgleish ,  Anni Dalgleish

IPC: G01N21/00 ,  G01N21/55 ,  G01N21/47 ,  G01N21/17

CPC classification number: G01N21/55 ,  G01N21/47 ,  G01N21/49 ,  G01N2021/1793 ,  G01N2201/0675

Abstract: A sensing system is provided that includes a transmitter assembly with a light source and a microdisplay device, wherein the transmitter assembly defines an optical beam transmission path to provide illumination of a substantially one-dimensional (1D) region of a target area, the microdisplay device comprising a plurality of controllable elements for causing the illumination to be a substantially 1D pattern of light along the 1D region. The system further includes a receiver assembly for defining a return optical signal transmission path from the 1D region and collecting return optical signals from the 1D region. The system also includes a processing component for generating sensor information associated with the 1D region by processing the return optical signals from the 1D region with return optical signals from adjacent 1D regions using a distributed compressive sensing (DCS) technique.

Abstract translation: 提供了一种感测系统，其包括具有光源和微型显示装置的发射器组件，其中发射器组件限定光束传输路径以提供目标区域的基本上一维（1D）区域的照明，微显示器件 包括多个可控元件，用于使得照明是沿1D区域的大致1D图案的光。 该系统还包括用于从1D区域定义返回光信号传输路径并收集来自1D区域的返回光信号的接收器组件。 该系统还包括用于通过使用分布式压缩感测（DCS）技术处理来自1D区域的返回光信号和来自相邻1D区域的返回光信号来产生与1D区域相关联的传感器信息的处理部件。