公开(公告)号：US5203339A

公开(公告)日：1993-04-20

申请号：US722823

申请日：1991-06-28

Applicant: Alexander Knuttel ,  Jay R. Knutson

Inventor： Alexander Knuttel ,  Jay R. Knutson

IPC: G01J1/04 ,  G01J9/02 ,  G01N21/41 ,  G01N21/45 ,  G01N21/47 ,  G01N21/65 ,  G01N21/76 ,  G01N21/85 ,  G01N27/447

CPC classification number: G01J1/04 ,  G01J1/0422 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01N21/4795 ,  G01N27/44721 ,  G01J2009/0203 ,  G01N2021/1738 ,  G01N2021/1759 ,  G01N2021/178 ,  G01N2021/1782 ,  G01N2021/4173 ,  G01N2021/451 ,  G01N2021/4702 ,  G01N21/645 ,  G01N21/65 ,  G01N21/76 ,  G01N21/85 ,  G01N2201/0893

Abstract: Imaging of a turbid object utilizes interference among the modulation wavefronts of a plurality of modulated light rays propagating through the object by diffusion and having predetermined phases relative to one another. A computer controlled phase and amplitude selecting device, such as a zone plate, is used to modulate light rays at appropriate phases in order to obtain constructive interference only at a predetermined portion of the object, including one or more preselected voxels. The rays reflected from (or diffusively transmitted through) the predetermined portion are received simultaneously at a detector, thus providing simultaneously all the data necessary to describe or image the portion. A single detector element may be used to detect the scattered reflected or transmitted light from the portion and to generate a signal representing the amplitude and phase characteristics for the modulation wavefront, thereby to provide absorption (and other) characteristics descriptive of the portion. An array of detectors may be used to detect the light from a plurality of individual voxels simultaneously and to provide such characteristics for each of the voxels. By dynamically controlling the phase and amplitude selecting device, the voxels selected for imaging are changed without mechanical scanning. Light rays having different frequencies may be modulated to provide complete absorption spectra for an arbitrarily selected portion of the object.

Abstract translation: 浑浊物体的成像利用通过扩散传播通过物体的多个调制光线的调制波前的相互干扰，并相对于彼此具有预定的相位。 使用计算机控制的相位和幅度选择装置（例如区域板）在适当的相位调制光线，以便仅在物体的预定部分（包括一个或多个预选的体素）处获得建设性的干扰。 从（或扩散传输）预定部分反射的光线在检测器处同时接收，从而同时提供描述或成像该部分所需的所有数据。 可以使用单个检测器元件来检测来自该部分的散射的反射或透射的光并且产生表示调制波前的幅度和相位特性的信号，从而提供描述该部分的吸收（和其它）特性。 可以使用一组检测器来同时检测来自多个单独体素的光，并为每个体素提供这样的特征。 通过动态地控制相位和幅度选择装置，选择用于成像的体素没有机械扫描而改变。 可以调制具有不同频率的光线，以便为对象的任意选择的部分提供完整的吸收光谱。

公开(公告)号：US20180348119A1

公开(公告)日：2018-12-06

申请号：US15994431

申请日：2018-05-31

Applicant: Government of the United States of America, as represented by the Secretary of Commerce

Inventor： Jeeseong C. Hwang ,  Heidrun Wabnitz

IPC: G01N21/25 ,  G01N21/27 ,  G01N33/49 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/00

CPC classification number: G01N21/255 ,  A61B5/14553 ,  A61B5/1495 ,  A61B5/7246 ,  G01N21/27 ,  G01N21/4785 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4925 ,  G01N2021/4797 ,  G01N2201/0675 ,  G01N2201/0683 ,  G01N2201/0893

Abstract: An optical phantom produces a time-resolved diffuse reflectance spectrum and includes: a light source; a spatial light modulator; and an optical delay line including optical fibers of different length that produce different time-of-flight distributions, such that different time-of-flight distributions are combined and produce phantom light having the time-resolved diffuse reflectance spectrum.

公开(公告)号：US5292483A

公开(公告)日：1994-03-08

申请号：US938818

申请日：1992-09-01

Applicant: Wilbur I. Kaye

Inventor： Wilbur I. Kaye

IPC: G01J1/04 ,  G01J9/02 ,  G01N21/41 ,  G01N21/45 ,  G01N21/47 ,  G01N21/65 ,  G01N21/76 ,  G01N21/85 ,  G01N27/447 ,  G01J1/58 ,  G01N21/49

CPC classification number: G01J1/04 ,  G01J1/0422 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01N21/4795 ,  G01N27/44721 ,  G01J2009/0203 ,  G01N2021/1738 ,  G01N2021/1759 ,  G01N2021/178 ,  G01N2021/1782 ,  G01N2021/4173 ,  G01N2021/451 ,  G01N2021/4702 ,  G01N21/645 ,  G01N21/65 ,  G01N21/76 ,  G01N21/85 ,  G01N2201/0893

Abstract: Focusing a generated radiation signal on a detector is effected by a curvilinear surface. The radiation beam signal from the reflected surface is collimated or focused on the detector. Light scattered, Raman scattered, fluorescence, chemiluminescence, phosphorescence radiation signals from particles as a result of a chemical procedure or reaction is enhanced through this focusing technique. The enhanced signal which is detected is subsequently measured through different detection techniques.

Abstract translation: 将生成的辐射信号聚焦在检测器上由曲线表面实现。 来自反射表面的辐射束信号被准直或聚焦在检测器上。 通过这种聚焦技术增强了散射，拉曼散射，荧光，化学发光，来自颗粒的磷光辐射信号，作为化学过程或反应的结果。 随后通过不同的检测技术测量检测到的增强信号。