公开(公告)号：US20170082546A1

公开(公告)日：2017-03-23

申请号：US15276397

申请日：2016-09-26

Applicant: NIKON CORPORATION

Inventor： Fumihiro DAKE ,  Hiroki YAZAWA

IPC: G01N21/64 ,  G02B21/36 ,  G02B21/16 ,  G01N21/63 ,  G02B21/08 ,  G02F1/11

CPC classification number: G01N21/6458 ,  G01N21/636 ,  G01N2201/0675 ,  G01N2201/0697 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/086 ,  G02B21/16 ,  G02B21/367 ,  G02B27/58 ,  G02F1/11

Abstract: A super-resolution observation device includes an illumination optical system that focus a first illuminating light at optical frequency ω1 and a second illuminating light at optical frequency ω2 on a region of an observation object plane; a modulation unit that modulates a property of the first illuminating light heading toward the region at a modulation frequency fm; and an extraction unit that extracts a component at the optical frequency ω1 or ω2 from a light generated in the region according to the first illuminating light and the second illuminating light, the component of which the property changes at a frequency higher than the modulation frequency fm.

公开(公告)号：US20240389852A1

公开(公告)日：2024-11-28

申请号：US18790145

申请日：2024-07-31

Applicant: NIKON CORPORATION

Inventor： Hiroki YAZAWA

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/15

Abstract: A model eye is disposed on a reference light path in order to obtain a good tomographic image.
A model eye is disposed on a reference light path of reference light in a reference optical system so as to reflect or scatter the reference light at a model retina in order to form an interference optical system used to obtain interference light from the reference light of the reference optical system and signal light illuminated onto an examined eye in a signal optical system. This enables an increase in a difference between light paths of the reference light and the signal light to be prevented from increasing as an incident angle of the signal light with respect to the center of a pupil of the examined eye increases.

公开(公告)号：US20210307602A1

公开(公告)日：2021-10-07

申请号：US17057278

申请日：2019-05-23

Applicant: NIKON CORPORATION

Inventor： Hiroki YAZAWA

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/15

Abstract: A model eye is disposed on a reference light path of reference light in a reference optical system so as to reflect or scatter the reference light at a model retina in order to form an interference optical system used to obtain interference light from the reference light of the reference optical system and signal light illuminated onto an examined eye in a signal optical system.

公开(公告)号：US20170082545A1

公开(公告)日：2017-03-23

申请号：US15275707

申请日：2016-09-26

Applicant: NIKON CORPORATION

Inventor： Fumihiro DAKE ,  Tomoko UJIKE ,  Hiroki YAZAWA

IPC: G01N21/64 ,  G01N21/65 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/6445 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0096

Abstract: A super-resolution observation device includes an illumination optical system collecting a first illuminating light having a first optical frequency co, on a first region of an observation object, collecting a second illuminating light having a second optical frequency ω2′ on a second region partially overlapping the first region, and collecting a third illuminating light having a third optical frequency ω2 on a third region containing a non-overlap region which is a region of the first region and does not overlap the second region; and an extraction unit extracting a signal light generated in accordance with a change in an energy level of a substance in the non-overlap region from a light generated in all of the first region, the second region, and the third region.

公开(公告)号：US20170038300A1

公开(公告)日：2017-02-09

申请号：US15298864

申请日：2016-10-20

Applicant: NIKON CORPORATION

Inventor： Fumihiro DAKE ,  Hiroki YAZAWA

IPC: G01N21/64 ,  G02B21/06 ,  G02B21/36 ,  G02B21/16

CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/12 ,  G02B21/0032 ,  G02B21/0056 ,  G02B21/0072 ,  G02B21/06 ,  G02B21/16 ,  G02B21/36 ,  G02B21/367

Abstract: A structured illumination microscopic device includes a first spatial modulation unit spatially modulating a fluorescent sample using an excitation light having a sinusoidal illumination distribution of a spatial frequency K and having an optical frequency ω1 for shifting a fluorescent substance to an excitation level; a second spatial modulation unit spatially modulating the fluorescent sample using a stimulation light having a sinusoidal illumination distribution of a spatial frequency K and having an optical frequency ω2 for shifting the excited fluorescent substance to a base level; and an imaging unit obtaining, as a modulated image, an image of the fluorescent sample with spontaneously emitted light generated at the fluorescent sample in accordance with the excitation light and the stimulation light.

Abstract translation: 一种结构化照明显微镜装置，包括：第一空间调制单元，其使用具有空间频率K的正弦照明分布且具有用于将荧光物质移动到激发电平的光频率ω1的激发光对荧光样品进行空间调制; 使用具有空间频率K的正弦照明分布并且具有用于将激发的荧光物质移动到基准电平的光频率ω2的刺激光对荧光样品进行空间调制的第二空间调制单元; 以及成像单元，其根据所述激发光和所述刺激光获得在所述荧光样品处产生的自发发射的光的荧光样品的图像作为调制图像。