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    METHODS AND SYSTEMS FOR THREE DIMENSIONAL OPTICAL IMAGING, SENSING, PARTICLE LOCALIZATION AND MANIPULATION
    2.
    发明申请
    METHODS AND SYSTEMS FOR THREE DIMENSIONAL OPTICAL IMAGING, SENSING, PARTICLE LOCALIZATION AND MANIPULATION 有权
    用于三维光学成像，感测，粒子定位和操作的方法和系统

    公开(公告)号：US20150035946A1

    公开(公告)日：2015-02-05

    申请号：US14465543

    申请日：2014-08-21

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Sean Albert Quirin

    IPC: H04N13/02 ,  G06T7/00

    CPC classification number: H04N13/204 ,  G06T7/77 ,  G06T2207/10056 ,  G06T2207/10064

    Abstract: Embodiments include methods, systems, and/or devices that may be used to image, obtain three-dimensional information from a scene, and/or locate multiple small particles and/or objects in three dimensions. A point spread function (PSF) with a predefined three dimensional shape may be implemented to obtain high Fisher information in 3D. The PSF may be generated via a phase mask, an amplitude mask, a hologram, or a diffractive optical element. The small particles may be imaged using the 3D PSF. The images may be used to find the precise location of the object using an estimation algorithm such as maximum likelihood estimation (MLE), expectation maximization, or Bayesian methods, for example. Calibration measurements can be used to improve the theoretical model of the optical system. Fiduciary particles/targets can also be used to compensate for drift and other type of movement of the sample relative to the detector.

    Abstract translation: 实施例包括可以用于图像，从场景获取三维信息和/或定位三维中的多个小粒子和/或对象的方法，系统和/或设备。 可以实现具有预定三维形状的点扩散函数（PSF）以获得3D中的高Fisher信息。 PSF可以通过相位掩模，幅度掩模，全息图或衍射光学元件生成。 可以使用3D PSF对小颗粒进行成像。 例如，图像可以用于使用诸如最大似然估计（MLE），期望最大化或贝叶斯方法的估计算法来找到对象的精确位置。 校准测量可用于改善光学系统的理论模型。 受信颗粒/目标也可用于补偿样品相对于检测器的漂移和其他类型的运动。

    3-D localization and imaging of dense arrays of particles
    4.
    发明授权
    3-D localization and imaging of dense arrays of particles 有权

    公开(公告)号：US10657346B2

    公开(公告)日：2020-05-19

    申请号：US15856539

    申请日：2017-12-28

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Anthony Barsic

    IPC: G06K9/00 ,  G06T7/73 ,  G02B21/36 ,  G06K9/68 ,  G01N21/64 ,  G02B21/14

    Abstract: Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging device. A plurality of point spread function dictionary coefficients of the image may be estimated using a point spread function dictionary; where the point spread function dictionary can include a plurality of spread function responses corresponding to different particle positions. From the point spread function dictionary coefficients the number of particles in the image can be determined. Moreover location of each particle in the image can be determined from the point spread function dictionary coefficients.

    Method and/or system for stabilization, tracking, and/or control of microscopic systems
    5.
    发明授权
    Method and/or system for stabilization, tracking, and/or control of microscopic systems 有权

    公开(公告)号：US10215975B2

    公开(公告)日：2019-02-26

    申请号：US15018684

    申请日：2016-02-08

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Wyatt Mohrman ,  Ginni Grover

    IPC: G02B21/16 ,  G02B21/36 ,  G02B21/12 ,  G02B21/24

    Abstract: Some embodiments of the invention include a system comprising a positioning device configured to a hold a sample and adjust a position of a sample in response to receiving a drift compensation signal; a first light source disposed to transilluminate the sample; a second light source disposed to epi-illuminate the sample; an optical system configured to receive light from the sample and generate a three-dimensional point spread function from the light from the sample; an image sensor disposed relative to the optical system that produces an image from the light collected from the sample via the optical system; and logic electrically coupled with the image detector and the positioning device, the logic configured to determine one or more drift compensation values from images imaged by the image detector, and configured to send one or more drift compensation signals to the positioning device.

    IMAGING THROUGH SCATTERING MEDIA WITH HIGH SIGNAL TO NOISE RATIO AND RESOLUTION
    6.
    发明申请
    IMAGING THROUGH SCATTERING MEDIA WITH HIGH SIGNAL TO NOISE RATIO AND RESOLUTION 审中-公开
    通过具有高信号噪声比和分辨率的散射介质成像

    公开(公告)号：US20160356746A1

    公开(公告)日：2016-12-08

    申请号：US14913958

    申请日：2014-08-26

    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

    Inventor： Rafael Piestun ,  Hengyi Ju ,  Jacob Dove ,  Antonio Miguel Caravacca-Aguirre ,  Todd Murray ,  Donald Conkey

    IPC: G01N29/24 ,  G01N29/06

    CPC classification number: G01N29/2418 ,  A61B5/0095 ,  G01N21/1702 ,  G01N29/0654 ,  G01N2021/1706 ,  G01N2201/0675

    Abstract: Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Embodiments of the invention can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.

    Abstract translation: 公开了系统和方法来增强散射材料后面，通过或内部的三维光声成像。 本发明的实施例可以在散射体之前使用波前整形来增加超声波换能器焦点中的光能密度和/或增强光强度。 由放置在散射介质后面的物体引起的光声信号可以用作反馈以优化波前，使光声振幅能够提高一个数量级。 使用增强的光强度，可以在二维扫描物体和/或可以在对数据进行后处理以重构图像之前重新优化波阵面来扫描点。 时间光声信号提供重建第三维信息的信息。

    Systems And Methods To Probe Ocular Structures
    7.
    发明申请
    Systems And Methods To Probe Ocular Structures 有权

    公开(公告)号：US20220395394A1

    公开(公告)日：2022-12-15

    申请号：US17774729

    申请日：2020-11-05

    Applicant: The Regents of the University of Colorado, a body corporate ,  SORBONNE UNIVERSITÉ

    Inventor： Rafael Piestun ,  Kristina Irsch

    IPC: A61F9/008 ,  A61B3/10

    Abstract: Systems, methods and software for scanning an ocular structure of an eye are provided. A method includes projecting a light onto the ocular structure, and scanning, by natural movements of the living eye, the light in a region of the living eye. Applicable ocular structures can include an ocular surface, a cornea, a sclera, an iris, a crystalline lens, an ocular fundus, a retina, a choroid, and a vitreous humor. A system includes a light source to create light, and optics to focus the light from the light source onto the ocular structure and to collect secondary light coming from the eye towards a detector. The system also includes a tracking system to register positions of the eye at different times, and a computer system to receive signals coupled from the tracking system representative of eye positions at different times and associate the signals with the tracking position.

    Wavefront Shaping With A 1D Spatial Light Modulator
    8.
    发明申请
    Wavefront Shaping With A 1D Spatial Light Modulator 有权

    公开(公告)号：US20210255488A1

    公开(公告)日：2021-08-19

    申请号：US17271135

    申请日：2019-08-26

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Omer Tzang ,  Eyal Niv

    IPC: G02F1/01 ,  G02B27/48

    Abstract: Controlling the propagation and interaction of light in complex media has sparked major interest. Unfortunately, spatial light modulation devices suffer from limited speed precluding real-time applications (e.g., imaging in live tissue). To address this problem, various embodiments use a phase-control technique to characterize complex media based on use of fast 1D spatial modulators and 1D-to-2D transformation performed by the same medium being analyzed. Some embodiments use a micro-electro-mechanical grating light valve (GLV) with 1088 degrees of freedom modulated at 350 KHz, enabling unprecedented high-speed wavefront measurements. Some embodiments continuously measure the transmission matrix, calculate the optimal wavefront and project a focus through various dynamic scattering samples in real-time, (e.g., within 2.4 ms per cycle). As such, some embodiments improve, by more than an order of magnitude, prior wavefront shaping modulation speed and open new opportunities for optical processing using 1D-to-2D transformations.

    Methods And Systems For Control Of Nonlinear Light Transmission
    9.
    发明申请
    Methods And Systems For Control Of Nonlinear Light Transmission 审中-公开

    公开(公告)号：US20200249541A1

    公开(公告)日：2020-08-06

    申请号：US16723196

    申请日：2019-12-20

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Omer Tzang ,  Rafael Piestun ,  Antonio Miguel Caravaca-Aguirre ,  Kelvin Wagner

    IPC: G02F1/365 ,  G02F1/35

    Abstract: Recent remarkable progress in wave-front shaping has enabled control of light propagation inside linear media to focus and image through scattering objects. In particular, light propagation in multimode fibers comprises complex intermodal interactions and rich spatiotemporal dynamics. Control of physical phenomena in multimode fibers and its applications is in its infancy, opening opportunities to take advantage of complex mode interactions. Various embodiments of the present technology provide wave-front shaping for controlling nonlinear phenomena in multimode fibers. Using a spatial light modulator at the fiber's input and a genetic algorithm optimization, some embodiments control a highly nonlinear stimulated Raman scattering cascade and its interplay with four wave mixing via a flexible implicit control on the superposition of modes that are coupled into the fiber.

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