公开(公告)号：US20180245118A1

公开(公告)日：2018-08-30

申请号：US15753378

申请日：2016-08-17

申请人： ZuChem, Inc.

发明人： Micah Douglas Shepherd

IPC分类号： C12P19/60 ,  C12N9/12 ,  C12N9/88 ,  C12P19/18

CPC分类号： C12P19/60 ,  A61K35/00 ,  A61K35/66 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1241 ,  C12N9/88 ,  C12N9/90 ,  C12P19/18 ,  C12Y101/01049 ,  C12Y206/01 ,  C12Y207/07024 ,  C12Y402/01046 ,  C12Y501/03013 ,  Y02A50/473

摘要： The invention provides compositions and methods for the production of TDP-deoxysugars.

公开(公告)号：US10059920B2

公开(公告)日：2018-08-28

申请号：US15112364

申请日：2015-01-09

申请人： University of Delaware

发明人： Eleftherios T. Papoutsakis ,  Sergios Nicolaou ,  Alan Fast ,  Vasiliki Falara ,  Robert Kyle Bennett ,  William Brian Whitaker ,  Nicholas Richard Sandoval ,  Jacqueline Gonzalez ,  Maciek Antoniewicz

IPC分类号： C12N1/32 ,  C12P7/16 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12N9/04 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70

CPC分类号： C12N1/32 ,  C12N9/0006 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70 ,  C12P7/16 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/625 ,  Y02E50/10

摘要： A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.

公开(公告)号：US10036042B2

公开(公告)日：2018-07-31

申请号：US15169894

申请日：2016-06-01

申请人： Research Foundation of the City University of New York

发明人： Eleanore T. Wurtzel ,  Jesús Beltrán

IPC分类号： C12P5/02 ,  C12N9/90 ,  C12P23/00 ,  C12P5/00

CPC分类号： C12P5/026 ,  C12N9/90 ,  C12P5/007 ,  C12P23/00 ,  C12Y502/01012

摘要： A method for isomerizing a double bond is provided. A substrate is exposed to an isomerase enzyme, wherein the isomerase enzyme comprises a redox-regulated ligand switch and heme b cofactor. A reducing agent is added which changes iron (III) to iron (II). The enzyme isomerizes double bonds in the iron (II) state but not in the iron (III) state. In one embodiment, the enzyme is homologous with 15-cis-ζ-carotene isomerase (Z-ISO).

公开(公告)号：US20180179558A1

公开(公告)日：2018-06-28

申请号：US15726978

申请日：2017-10-06

申请人： Braskem S.A.

发明人： Daniel Johannes Koch ,  Mateus Schreiner LOPES ,  Ane Fernanda Beraldi Zeidler ,  Lucas Pedersen Parizzi

IPC分类号： C12P7/28 ,  C12N9/10 ,  C12N9/02 ,  C12N9/88 ,  C12N9/12 ,  C12N9/90 ,  C12N15/52 ,  C12P5/02 ,  C12P7/04 ,  C12P7/26 ,  C12P7/18

CPC分类号： C12P7/28 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P5/026 ,  C12P7/04 ,  C12P7/18 ,  C12P7/26 ,  C12P2203/00 ,  C12Y102/01021 ,  C12Y203/01009 ,  C12Y207/01047 ,  C12Y208/03008 ,  C12Y401/01004 ,  C12Y401/02013 ,  C12Y501/03

摘要： The present application relates to recombinant microorganisms useful in the biosynthesis of monoethylene glycol (MEG) and one or more three-carbon compounds such as acetone, isopropanol or propene. The MEG and one or more three-carbon compounds described herein are useful as starting material for production of other compounds or as end products for industrial and household use. The application further relates to recombinant microorganisms co-expressing a C2 branch pathway and a C3 branch pathway for the production of MEG and one or more three-carbon compounds. Also provided are methods of producing MEG and one or more three-carbon compounds using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally the products MEG and one or more three-carbon compounds.

公开(公告)号：US20180148728A1

公开(公告)日：2018-05-31

申请号：US15540611

申请日：2015-12-31

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Pyung Cheon LEE ,  Bo Hyun CHOI ,  Sun Hyoung CHOI

IPC分类号： C12N15/70 ,  C12P23/00 ,  C12N15/01 ,  C12N9/10 ,  C12N9/02 ,  C12N9/90

CPC分类号： C12N15/70 ,  C12N9/001 ,  C12N9/0073 ,  C12N9/1048 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/01 ,  C12P23/00 ,  C12Y103/9903 ,  C12Y114/13129 ,  C12Y205/01001 ,  C12Y205/01032 ,  C12Y505/01019

摘要： Provided is a mutant having an ability to overproduce carotenoids and a method for producing carotenoids by using the mutant. The mutant, of which mutations are induced by irradiation after being transformed with a recombinant vector according to the subject matter, has an excellent ability to produce carotenoids and can be mass-produced, and thus can be useful in various industrial fields, which use carotenoids, such as cosmetics, food, and feed.

公开(公告)号：US20180119176A1

公开(公告)日：2018-05-03

申请号：US15803735

申请日：2017-11-03

申请人： The Regents of the University of California

发明人： Jay D. Keasling ,  Christopher B. Eiben

IPC分类号： C12P5/00 ,  C12N15/52 ,  C12N9/10 ,  C12N9/04 ,  C12N9/88 ,  C12N9/90 ,  C12P9/00 ,  C12N9/12

CPC分类号： C12P5/007 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P9/00 ,  C12Y101/01034 ,  C12Y203/01009 ,  C12Y203/0301 ,  C12Y205/01001 ,  C12Y207/01036 ,  C12Y402/03027 ,  C12Y503/03002

摘要： Cells comprising a heterologous metabolic pathway are configured to produce a terpene product containing non-multiples of five carbon, particularly wherein the pathway comprises heterologous Lepidoptera insect juvenile hormone biosynthetic pathway enzymes of the insect's mevalonate pathway.

公开(公告)号：US09957328B2

公开(公告)日：2018-05-01

申请号：US15667649

申请日：2017-08-03

申请人： UCB PHARMA, S.A.

发明人： Mark Ellis ,  David Paul Humphreys

IPC分类号： C12N1/20 ,  C07K16/28 ,  C12N9/90

CPC分类号： C07K16/2875 ,  C07K2317/14 ,  C07K2317/55 ,  C12N9/90

摘要： The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen-binding fragment thereof specifically binding to CD154.

公开(公告)号：US20180105838A1

公开(公告)日：2018-04-19

申请号：US15557370

申请日：2016-03-11

申请人： BASF SE

发明人： Jens SCHRADER ,  Markus BUCHHAUPT ,  Frank SONNTAG ,  Cora KRONER ,  Heike BRÜSER ,  Hartwig SCHRÖDER ,  Ralf PELZER

IPC分类号： C12P5/00 ,  C12N9/88 ,  C12N9/10 ,  C12N9/04 ,  C12N9/12 ,  C12N9/90

CPC分类号： C12P5/007 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/1229 ,  C12N9/88 ,  C12N9/90 ,  C12Y101/01034 ,  C12Y203/0301 ,  C12Y205/0101 ,  C12Y207/01036 ,  C12Y207/04002 ,  C12Y401/01 ,  C12Y401/01033 ,  C12Y402/03104 ,  C12Y503/03002

摘要： The invention relates to microbial terpene production. Known methods for microbial production of terpenes are mostly based on the direct conversion of sugars. Therefore alternative substrates, in particular alternative carbon sources, for use in microbial terpene production were desirable. The invention relates to a methylotrophic bacterium containing recombinant DNA coding for at least one polypeptide with enzymatic activity for heterologous expression in said bacterium, wherein said at least one polypeptide with enzymatic activity is selected from the group consisting an enzyme of a heterologous mevalonate pathway, a heterologous terpene synthase and optionally a heterologous synthase of a prenyl diphosphate precursor. The invention further relates in particular to a method for de novo microbial synthesis of sesquiterpenes or diterpenes from methanol and/or ethanol.

公开(公告)号：US09944918B2

公开(公告)日：2018-04-17

申请号：US15070787

申请日：2016-03-15

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Charles P. Venditti ,  Randy J. Chandler

IPC分类号： A61K48/00 ,  C07H21/04 ,  C12N15/74 ,  C12N9/90 ,  A61K38/00

CPC分类号： C12N9/90 ,  A61K38/00 ,  C12Y504/99002

摘要： Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered circulating methylmalonic acid levels in the treated animals, and resulted in prolonged hepatic expression of the product of synMUT transgene in vivo, human methylmalonyl-CoA mutase (MUT).

公开(公告)号：US09932619B2

公开(公告)日：2018-04-03

申请号：US14442694

申请日：2013-12-04

申请人： Evolva SA

发明人： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC分类号： C12P33/20 ,  C12P19/18 ,  C12P19/56 ,  C12N1/00 ,  C12N9/10 ,  C12P33/08 ,  C12N9/02 ,  C12N9/14 ,  C12N9/90 ,  C12P33/00 ,  C12P33/12 ,  C12N15/80

CPC分类号： C12P33/20 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1048 ,  C12N9/14 ,  C12N9/90 ,  C12N15/80 ,  C12P19/18 ,  C12P19/56 ,  C12P33/00 ,  C12P33/08 ,  C12P33/12 ,  C12Y114/00 ,  C12Y114/13132 ,  C12Y303/00 ,  C12Y504/99033

摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.