公开(公告)号：US20230233082A1

公开(公告)日：2023-07-27

申请号：US18047789

申请日：2022-10-19

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Muhammad MUJEEB-U-RAHMAN ,  Axel SCHERER

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/0026 ,  A61B5/1473 ,  A61B5/14532 ,  A61B5/0031 ,  A61B5/14865 ,  A61B2560/0219 ,  A61B2562/028 ,  A61B2562/04 ,  A61B2562/125 ,  A61B2562/0209

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

公开(公告)号：US20210322300A1

公开(公告)日：2021-10-21

申请号：US17321296

申请日：2021-05-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER ,  Richard Daniel SMITH, JR.

IPC: A61K9/00 ,  A61B5/145 ,  A61B5/00 ,  A61J1/14

Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.

公开(公告)号：US20190090797A1

公开(公告)日：2019-03-28

申请号：US16144174

申请日：2018-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER

IPC: A61B5/1486 ,  G01N27/30 ,  G01N27/419 ,  A61B5/1459

Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.

公开(公告)号：US20180243720A1

公开(公告)日：2018-08-30

申请号：US15967543

申请日：2018-04-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Sameer WALAVALKAR ,  Axel SCHERER

IPC: B01J19/00 ,  G01N21/65

CPC classification number: B01J19/0046 ,  B01J2219/00585 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N21/65 ,  G01N21/658

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

公开(公告)号：US20170250048A1

公开(公告)日：2017-08-31

申请号：US15442408

申请日：2017-02-24

Applicant: California Institute of Technology

Inventor： Axel SCHERER ,  William M. JONES ,  Danil M. LUKIN ,  Sameer WALAVALKAR ,  Chieh-feng CHANG

IPC: H01J19/24 ,  H01J21/02 ,  H01J9/02

CPC classification number: H01J19/24 ,  H01J9/025 ,  H01J21/02 ,  H01J21/105 ,  H01J2209/0223

Abstract: Nanoscale field-emission devices are presented, wherein the devices include at least a pair of electrodes separated by a gap through which field emission of electrons from one electrode to the other occurs. The gap is dimensioned such that only a low voltage is required to induce field emission. As a result, the emitted electrons energy that is below the ionization potential of the gas or gasses that reside within the gap. In some embodiments, the gap is small enough that the distance between the electrodes is shorter than the mean-free path of electrons in air at atmospheric pressure. As a result, the field-emission devices do not require a vacuum environment for operation.

公开(公告)号：US20160067666A1

公开(公告)日：2016-03-10

申请号：US14621306

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Sameer WALAVALKAR ,  Axel SCHERER

IPC: B01J19/00 ,  C12Q1/68

CPC classification number: B01J19/0046 ,  B01J2219/00585 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N21/65 ,  G01N21/658

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

Abstract translation: 描述了纳米柱传感器的方法和系统。 纳米玻璃可以在基底上定义，金属沉积在纳米柱上。 热处理可以回流纳米柱上的金属，在纳米柱的顶端形成金属灯泡。 这些结构可以在用生物制剂进行功能化时具有增强的光学检测，或者可以通过与纳米柱上的金属层相互作用来检测气体，颗粒和液体。

公开(公告)号：US20150279948A1

公开(公告)日：2015-10-01

申请号：US14720429

申请日：2015-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Aditya RAJAGOPAL ,  Chieh-feng CHANG ,  Oliver PLETTENBURG ,  Stefan PETRY ,  Axel SCHERER ,  Charles L. TSCHIRHART

IPC: H01L29/41 ,  H01L29/735 ,  H01L29/78 ,  H01L29/49 ,  H01L29/45

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。

公开(公告)号：US20150223739A1

公开(公告)日：2015-08-13

申请号：US14621286

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Sameer WALAVALKAR ,  Chieh-feng CHANG ,  Axel SCHERER ,  Brandon MARIN ,  Scott E. FRASER

IPC: A61B5/1459 ,  A61B5/1473 ,  A61B5/07 ,  A61B5/00 ,  H01L27/146 ,  G01N21/65

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/076 ,  A61B5/14735 ,  A61B5/6848 ,  A61B5/686 ,  A61B2562/0233 ,  A61B2562/0285 ,  A61B2562/12 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/658 ,  H01L27/14698

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

Abstract translation: 描述了纳米柱传感器的方法和系统。 纳米玻璃可以在基底上定义，金属沉积在纳米柱上。 热处理可以回流纳米柱上的金属，在纳米柱的顶端形成金属灯泡。 这些结构可以在用生物制剂进行功能化时具有增强的光学检测，或者可以通过与纳米柱上的金属层相互作用来检测气体，颗粒和液体。

公开(公告)号：US20150209690A1

公开(公告)日：2015-07-30

申请号：US14614376

申请日：2015-02-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： George MALTEZOS ,  Alvaro GOMEZ ,  Frank GOMEZ ,  Axel SCHERER

IPC: B01D15/22 ,  B29C65/70 ,  B01L3/00

CPC classification number: B01D15/22 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/12 ,  B01L2300/16 ,  B29C65/70 ,  B29K2027/12 ,  B29L2031/756 ,  G01N30/603 ,  G01N30/6095 ,  Y10T29/49826

Abstract: A device and method for making a microfluidic separation device. A microfluidic separation device could include a microfluidic column having an inlet, the microfluidic column being configured to hold a first fluid and the microfluidic column including a porous portion, and an outlet attached to the microfluidic column, the outlet being configured to output a second fluid. The method may include providing a microfluidic column having an inlet, configuring the microfluidic column to hold a first fluid, forming a porous portion in the microfluidic column, and attaching an outlet to the microfluidic column.

Abstract translation: 用于制造微流体分离装置的装置和方法。 微流体分离装置可以包括具有入口的微流体柱，所述微流体柱被配置为保持第一流体，并且所述微流体柱包括多孔部分和连接到所述微流体柱的出口，所述出口构造成输出第二流体 。 该方法可以包括提供具有入口的微流体柱，构造微流体柱以保持第一流体，在微流体柱中形成多孔部分，以及将出口附接到微流体柱。

公开(公告)号：US20150057516A1

公开(公告)日：2015-02-26

申请号：US14465777

申请日：2014-08-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Muhammad MUJEEB-U-RAHMAN ,  Axel SCHERER

IPC: A61B3/10 ,  A61B5/00 ,  H05K3/00 ,  H05K3/14 ,  H05K3/12 ,  A61B5/145 ,  C23C16/06

CPC classification number: A61B3/101 ,  A61B5/0031 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/6821 ,  A61B2560/0219 ,  H05K1/16 ,  H05K3/0014 ,  H05K3/1216 ,  H05K3/146 ,  H05K2201/0108 ,  H05K2201/10151

Abstract: Novel methods and systems for monitoring the health of an eye are disclosed. For example, a resonant circuit may be fabricated on a contact lens and this circuit may be coupled to a second circuit having the same resonant current frequency. A change in a property of the eye fluid contacted by the sensor in the contact lens is communicated to an external device and a remedying action is suggested to the wearer.

Abstract translation: 公开了用于监测眼睛健康的新方法和系统。 例如，可以在隐形眼镜上制造谐振电路，并且该电路可以耦合到具有相同谐振电流频率的第二电路。 由隐形眼镜中的传感器接触的眼睛流体的特性的变化被传递到外部装置，并且向佩戴者提出补救动作。