公开(公告)号：US20210076954A1

公开(公告)日：2021-03-18

申请号：US17020740

申请日：2020-09-14

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Dominic Yurk ,  Yaser Abu-Mostafa ,  Alaina Ann Brinley Rajagopal

IPC: A61B5/021 ,  A61B5/00

Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.

公开(公告)号：US10889863B2

公开(公告)日：2021-01-12

申请号：US16102583

申请日：2018-08-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Emil P. Kartalov ,  Aditya Rajagopal ,  Axel Scherer ,  Mark D. Goldberg

IPC: C12Q1/68 ,  C12Q1/70 ,  C12Q1/6883 ,  C12Q1/6851

Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.

公开(公告)号：US20190032112A1

公开(公告)日：2019-01-31

申请号：US16051736

申请日：2018-08-01

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Emil P. Kartalov

IPC: C12Q1/686 ,  C07H21/04 ,  G01N21/64

Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.

公开(公告)号：US09960238B2

公开(公告)日：2018-05-01

申请号：US14720429

申请日：2015-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Aditya Rajagopal ,  Chieh-feng Chang ,  Oliver Plettenburg ,  Stefan Petry ,  Axel Scherer ,  Charles L. Tschirhart

IPC: H01L29/00 ,  H01L29/41 ,  H01L29/73 ,  H01L29/78 ,  B82Y15/00 ,  H01L29/732 ,  H01L29/06 ,  G01N27/414 ,  H01L29/45 ,  H01L29/49 ,  H01L29/735

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

公开(公告)号：US20170362636A1

公开(公告)日：2017-12-21

申请号：US15623974

申请日：2017-06-15

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Emil P. Kartalov

IPC: C12Q1/68 ,  C07H21/04 ,  G01N21/64

CPC classification number: C12Q1/686 ,  B01J2219/00659 ,  C07H21/04 ,  G01N2021/6417

Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.

公开(公告)号：US09618477B2

公开(公告)日：2017-04-11

申请号：US13967108

申请日：2013-08-14

Applicant: California Institute of Technology

Inventor： Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello ,  Aditya Rajagopal ,  Andrew P. Homyk ,  Erika Garcia

IPC: G01N27/447 ,  C12Q1/68 ,  G01N33/487 ,  B82Y30/00

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

公开(公告)号：US09606060B2

公开(公告)日：2017-03-28

申请号：US13740112

申请日：2013-01-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6408

Abstract: A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed.

公开(公告)号：US09525312B2

公开(公告)日：2016-12-20

申请号：US14840819

申请日：2015-08-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

IPC: H04B10/08 ,  H02J17/00 ,  G01J3/02 ,  H01L31/0352 ,  H03F3/08 ,  H03F3/45 ,  H04B10/80 ,  H02S40/38 ,  H01L31/0475 ,  H01L31/054 ,  A61B5/00

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes a method for optically powering transducers and related transducers with a photovoltaic collector. An optical fiber power delivery method and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了一种用于利用光伏收集器对换能器和相关换能器进行光学供电的方法。 还提供了光纤功率传递方法和自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。

公开(公告)号：US09480426B2

公开(公告)日：2016-11-01

申请号：US14153819

申请日：2014-01-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Akram Sarwat Sadek

IPC: A61B5/1455 ,  A61B5/1459 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0031 ,  A61B5/14552 ,  A61B5/6867 ,  A61B2560/0219

Abstract: A process is described for testing a biomedical property of an internal tissue of a patient. Optical energy emitted by an external source is transferred through a nail of the patient to an instrument device implanted beneath the nail. A portion of the transferred optical energy is converted to electrical power for driving components of the implanted instrument. Using the electrical power, a characteristic of the internal tissue associated with the measurement of the biomedical property is sensed and an optical signal based on the sensed characteristic is transmitted through the nail to an external data reader.

Abstract translation: 描述了用于测试患者内部组织的生物医学性质的方法。 由外部源发出的光能通过患者的指甲转移到植入在指甲下方的器械装置。 转移的光能的一部分被转换成用于驱动植入的仪器的部件的电力。 使用电力，检测与生物医学性质的测量相关联的内部组织的特性，并且基于感测到的特性的光学信号通过指甲传输到外部数据读取器。

公开(公告)号：US09407055B2

公开(公告)日：2016-08-02

申请号：US14684280

申请日：2015-04-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Seheon Kim ,  Axel Scherer ,  Aditya Rajagopal ,  Chieh-Feng Chang

IPC: H01S3/06 ,  H01S3/091 ,  H01S3/102 ,  H01S3/02 ,  H01S3/115 ,  H01S5/30 ,  H01S3/105 ,  H01S5/06 ,  H01S5/10 ,  A61B5/1459

CPC classification number: H01S3/0627 ,  A61B5/1459 ,  H01S3/025 ,  H01S3/091 ,  H01S3/102 ,  H01S3/1028 ,  H01S3/105 ,  H01S3/115 ,  H01S5/0607 ,  H01S5/0612 ,  H01S5/1042 ,  H01S5/3013

Abstract: A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least a portion of light emitted by the optical source. The actuator switch is configured to be activated by a triggering event. Furthermore, the photovoltaic power source is coupled in a series connection with the actuator switch and the control element, the series connection configured to connect the photovoltaic power source to the control element of the microlaser when the actuator switch is activated by the triggering event.