公开(公告)号：US09618477B2

公开(公告)日：2017-04-11

申请号：US13967108

申请日：2013-08-14

Applicant: California Institute of Technology

Inventor： Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello ,  Aditya Rajagopal ,  Andrew P. Homyk ,  Erika Garcia

IPC: G01N27/447 ,  C12Q1/68 ,  G01N33/487 ,  B82Y30/00

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

公开(公告)号：US09525312B2

公开(公告)日：2016-12-20

申请号：US14840819

申请日：2015-08-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

IPC: H04B10/08 ,  H02J17/00 ,  G01J3/02 ,  H01L31/0352 ,  H03F3/08 ,  H03F3/45 ,  H04B10/80 ,  H02S40/38 ,  H01L31/0475 ,  H01L31/054 ,  A61B5/00

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes a method for optically powering transducers and related transducers with a photovoltaic collector. An optical fiber power delivery method and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了一种用于利用光伏收集器对换能器和相关换能器进行光学供电的方法。 还提供了光纤功率传递方法和自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。

公开(公告)号：US09390936B2

公开(公告)日：2016-07-12

申请号：US14527039

申请日：2014-10-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  Stephanie Tombrello

Inventor： Michael D. Henry ,  Andrew P. Homyk ,  Axel Scherer ,  Thomas A. Tombrello ,  Sameer Walavalkar

IPC: G01N1/18 ,  H01L21/308 ,  B81C1/00 ,  H01L21/3065 ,  G01N1/40

CPC classification number: B81C1/00111 ,  B01J19/0046 ,  B01J2219/00504 ,  B01J2219/00664 ,  B81B1/006 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C2201/0112 ,  B81C2201/0132 ,  B81C2201/0133 ,  B81C2201/0159 ,  G01N1/405 ,  H01L21/3065 ,  H01L21/30655 ,  H01L21/3081 ,  H01L21/3086 ,  Y10T436/25375

Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.

公开(公告)号：US08841712B2

公开(公告)日：2014-09-23

申请号：US13852480

申请日：2013-03-28

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Michael D. Henry ,  Sameer Walavalkar ,  Thomas A. Tombrello ,  Andrew P. Homyk

IPC: H01L29/76 ,  G01N27/327 ,  H01L29/66 ,  H01L29/78

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.

Abstract translation: 场效应纳米柱晶体管具有结合有生物医学部分的柱形门元件，其提供了优于现有技术器件的各种优点。 纳米柱晶体管的小尺寸允许有利地插入到细胞膜中，并且栅极元件的生物学特性作为用于感测小幅度电压（例如跨膜电池电位）的有利接口。 纳米柱晶体管可用于各种实施例中以刺激细胞，测量细胞反应或执行两种动作的组合。

公开(公告)号：US09406823B2

公开(公告)日：2016-08-02

申请号：US14329748

申请日：2014-07-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

IPC: H01L29/06 ,  H01L31/0352 ,  B82Y10/00 ,  H01L29/66 ,  H01L29/775 ,  H01L33/06 ,  B82Y40/00 ,  H01L29/12 ,  H01L29/41 ,  H01L21/02 ,  H01L29/267

CPC classification number: H01L31/035227 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/0243 ,  H01L21/02521 ,  H01L21/0259 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0676 ,  H01L29/127 ,  H01L29/267 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/775 ,  H01L33/06 ,  Y10S977/762

Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Abstract translation: 描述了使用硅纳米线制造自对准异质结构和半导体布置的方法。

公开(公告)号：US09243277B2

公开(公告)日：2016-01-26

申请号：US14753741

申请日：2015-06-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Michael D. Henry ,  Sameer Walavalkar ,  Thomas A. Tombrello ,  Andrew P. Homyk

IPC: G01R1/067 ,  G01R31/00 ,  C12Q1/02 ,  H01L29/78 ,  H01L29/66 ,  G01N27/327 ,  G01N27/414 ,  A61B5/04 ,  H01L29/41 ,  H01L29/423 ,  H01L29/49 ,  G01R1/073

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

公开(公告)号：US09099436B2

公开(公告)日：2015-08-04

申请号：US13852476

申请日：2013-03-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Michael D. Henry ,  Sameer Walavalkar ,  Thomas A. Tombrello ,  Andrew P. Homyk

IPC: G01R1/067 ,  H01L29/423 ,  H01L29/78 ,  H01L29/66 ,  G01N27/327 ,  G01N27/414 ,  A61B5/04 ,  H01L29/41 ,  H01L29/49 ,  G01R1/073

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。

公开(公告)号：US20130327645A1

公开(公告)日：2013-12-12

申请号：US13967108

申请日：2013-08-14

Applicant: California Institute of Technology

Inventor： Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello ,  Aditya Rajagopal ,  Andrew P. Homyk ,  Erika Garcia

IPC: G01N27/447

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Abstract translation: 本文公开了用于测序核酸的方法和装置。 本文还提供了用于测量具有大小允许DNA穿过纳米孔的纳米孔的DNA的装置。 可以测量通过纳米孔的DNA分子的电容。 电容测量可以相关，以确定通过纳米孔的碱基对序列来对DNA进行排序。

公开(公告)号：US09234872B2

公开(公告)日：2016-01-12

申请号：US14673700

申请日：2015-03-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

IPC: H01L29/772 ,  H01L29/02 ,  G01N27/414 ,  B82Y10/00 ,  H01L29/06 ,  H01L29/775 ,  H01L29/66 ,  B82Y15/00

CPC classification number: G01N27/4146 ,  B82Y10/00 ,  B82Y15/00 ,  H01L29/0676 ,  H01L29/66666 ,  H01L29/775

Abstract: Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.

公开(公告)号：US09154235B2

公开(公告)日：2015-10-06

申请号：US14306813

申请日：2014-06-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

IPC: H04B10/12 ,  H04B10/80 ,  G01J3/02 ,  H01L31/0352 ,  H03F3/08 ,  H03F3/45 ,  H02S40/38 ,  H01L31/0475 ,  H01L31/054 ,  A61B5/00

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes an optically powered transducer with a photovoltaic collector. An optical fiber power delivery method and system and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了具有光伏收集器的光学功率传感器。 还提供了光纤功率传递方法和系统以及自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。