公开(公告)号：US20240307026A1

公开(公告)日：2024-09-19

申请号：US18675500

申请日：2024-05-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Alaina Ann Brinley RAJAGOPAL ,  Aditya Rajagopal

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/14 ,  G01S15/89

CPC classification number: A61B8/0891 ,  A61B8/14 ,  A61B8/40 ,  A61B8/4236 ,  A61B8/4472 ,  G01S15/895

Abstract: A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.

公开(公告)号：US11998383B2

公开(公告)日：2024-06-04

申请号：US16927911

申请日：2020-07-13

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Alaina Ann Brinley Rajagopal

IPC: A61B7/04 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/145 ,  A61B8/00 ,  A61B8/02 ,  A61B8/06 ,  A61B8/08 ,  G01S15/89 ,  A61B5/021

CPC classification number: A61B7/04 ,  A61B5/0022 ,  A61B5/02055 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7264 ,  A61B8/4416 ,  A61B8/4477 ,  G01S15/8952 ,  G01S15/899 ,  A61B5/021 ,  A61B5/0816 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/7253 ,  A61B5/742 ,  A61B8/02 ,  A61B8/06 ,  A61B8/085 ,  A61B8/4209 ,  A61B8/461 ,  A61B8/565 ,  A61B2560/0214

Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.

公开(公告)号：US20210098076A1

公开(公告)日：2021-04-01

申请号：US16864744

申请日：2020-05-01

Applicant: California Institute of Technology

Inventor： Emil P. Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G16B25/00 ,  G16B5/00 ,  C12Q1/6851 ,  G16B25/20 ,  G16B40/10 ,  C12Q1/68 ,  G01N21/64 ,  C12Q1/6825

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US20190034583A1

公开(公告)日：2019-01-31

申请号：US15914356

申请日：2018-03-07

Applicant: California Institute of Technology

Inventor： Emil P. Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G06F19/20 ,  G01N21/64 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G06F19/12 ,  G06F17/10 ,  G06F17/11 ,  G06F19/24

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US10081844B2

公开(公告)日：2018-09-25

申请号：US15675048

申请日：2017-08-11

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Mark D. Goldberg ,  Erika F. Garcia ,  Xiomara L. Madero ,  Thomas A. Tombrello ,  Axel Scherer

IPC: C12P19/34 ,  C12Q1/70 ,  C12Q1/6851 ,  C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: Methods of detecting at least one genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, the first primer and the second primer are specific for the polynucleotide analyte. A signal generated by the fluorophore and quencher is measured. PCR is performed with the first primer and the second primer using the polynucleotide analyte as a template, thereby amplifying the template. A signal generated by the fluorophore and quencher from the PCR amplification product is measured. Comparison is made of the signals; and a determination is made of the presence or absence of the at least one genetic variation based i) on the change in signal as determined; and ii) by comparing said change to the change in signal observed upon PCR amplification for a corresponding polynucleotide analyte lacking the at least one genetic variation.

公开(公告)号：US20180030551A1

公开(公告)日：2018-02-01

申请号：US15675048

申请日：2017-08-11

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Mark D. Goldberg ,  Erika F. Garcia ,  Xiomara L. Madero ,  Thomas A. Tombrello ,  Axel Scherer

IPC: C12Q1/70 ,  C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

公开(公告)号：US09154235B2

公开(公告)日：2015-10-06

申请号：US14306813

申请日：2014-06-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

IPC: H04B10/12 ,  H04B10/80 ,  G01J3/02 ,  H01L31/0352 ,  H03F3/08 ,  H03F3/45 ,  H02S40/38 ,  H01L31/0475 ,  H01L31/054 ,  A61B5/00

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes an optically powered transducer with a photovoltaic collector. An optical fiber power delivery method and system and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了具有光伏收集器的光学功率传感器。 还提供了光纤功率传递方法和系统以及自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。

公开(公告)号：US08838394B2

公开(公告)日：2014-09-16

申请号：US13756760

申请日：2013-02-01

Applicant: California Institute of Technology

Inventor： Emil Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N33/48 ,  G01N31/00 ,  G06F17/10 ,  G01N21/64 ,  G06F19/12 ,  C12Q1/68 ,  G06F19/24 ,  G06F17/11

CPC classification number: G06F19/20 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G01N21/6486 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/24 ,  Y02A50/53 ,  C12Q2537/101 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/107

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。

公开(公告)号：US11950887B2

公开(公告)日：2024-04-09

申请号：US17020740

申请日：2020-09-14

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Dominic Yurk ,  Yaser Abu-Mostafa ,  Alaina Ann Brinley Rajagopal

IPC: A61B5/021 ,  A61B5/00

CPC classification number: A61B5/02133 ,  A61B5/6832 ,  A61B5/7405 ,  A61B5/02141

Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.

公开(公告)号：US20230240646A1

公开(公告)日：2023-08-03

申请号：US18128998

申请日：2023-03-30

Applicant: California Institute of Technology

Inventor： Alaina Ann Brinley Rajagopal ,  Aditya Rajagopal

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/14 ,  G01S15/89

CPC classification number: A61B8/0891 ,  A61B8/14 ,  A61B8/40 ,  A61B8/4236 ,  A61B8/4472 ,  G01S15/895

Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits an ultrasound signal that is reflected by the physiological structure to create a reflected ultrasound signal, the first transducer generates a first received signal from the reflected ultrasound signal, the second transducer generates a second received signal from the reflected ultrasound signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.