公开(公告)号：US20130207639A1

公开(公告)日：2013-08-15

申请号：US13764612

申请日：2013-02-11

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Chieh-Feng Chang ,  Akram Sarwat Sadek ,  Axel Scherer ,  Raymond Jimenez

IPC: G01R19/00

CPC classification number: G01R19/00 ,  A61B5/0031 ,  A61B5/04001 ,  A61B2560/0214 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/223

Abstract: A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described.

Abstract translation: 一种半导体衬底上的电压感测装置，包括一个或多个包括金属触点的输入端，包括激光发射器的输出端，将输入电连接到输出端的电路; 和电源模块。 还描述了制造该装置的方法。

公开(公告)号：US09480426B2

公开(公告)日：2016-11-01

申请号：US14153819

申请日：2014-01-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Akram Sarwat Sadek

IPC: A61B5/1455 ,  A61B5/1459 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0031 ,  A61B5/14552 ,  A61B5/6867 ,  A61B2560/0219

Abstract: A process is described for testing a biomedical property of an internal tissue of a patient. Optical energy emitted by an external source is transferred through a nail of the patient to an instrument device implanted beneath the nail. A portion of the transferred optical energy is converted to electrical power for driving components of the implanted instrument. Using the electrical power, a characteristic of the internal tissue associated with the measurement of the biomedical property is sensed and an optical signal based on the sensed characteristic is transmitted through the nail to an external data reader.

Abstract translation: 描述了用于测试患者内部组织的生物医学性质的方法。 由外部源发出的光能通过患者的指甲转移到植入在指甲下方的器械装置。 转移的光能的一部分被转换成用于驱动植入的仪器的部件的电力。 使用电力，检测与生物医学性质的测量相关联的内部组织的特性，并且基于感测到的特性的光学信号通过指甲传输到外部数据读取器。

公开(公告)号：US09128124B2

公开(公告)日：2015-09-08

申请号：US13764612

申请日：2013-02-11

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Chieh-Feng Chang ,  Akram Sarwat Sadek ,  Axel Scherer ,  Raymond Jimenez

IPC: G01R19/20 ,  G01R19/00 ,  A61B5/04 ,  A61B5/00

CPC classification number: G01R19/00 ,  A61B5/0031 ,  A61B5/04001 ,  A61B2560/0214 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/223

Abstract: A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described.

Abstract translation: 一种半导体衬底上的电压感测装置，包括一个或多个包括金属触点的输入端，包括激光发射器的输出端，将输入电连接到输出端的电路; 和电源模块。 还描述了制造该装置的方法。

公开(公告)号：US09011330B2

公开(公告)日：2015-04-21

申请号：US13938156

申请日：2013-07-09

Applicant: California Institute of Technology

Inventor： Akram Sarwat Sadek ,  Axel Scherer ,  Muhammad Mujeeb-U-Rahman

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473

CPC classification number: A61B5/6846 ,  A61B5/14503 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/686 ,  A61B5/6876 ,  A61B2562/028 ,  A61B2562/14 ,  A61B2562/164

Abstract: An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more sensors on the chip layer and coupled to the power source and a hydrogel matrix including one or more angiogenesis stimulating factors in contact with the chip layer. The stimulating factors stimulate growth of organic material through the plurality of holes when the biosensor is implanted in a subject.

Abstract translation: 本文描述了可植入的生物相容性生物传感器。 生物传感器包括芯片层，其包括垂直于其上形成的多个孔，电源，芯片层上的一个或多个传感器并耦合到电源，以及水凝胶基质，其包括与芯片接触的一个或多个血管生成刺激因子 层。 当将生物传感器植入受试者时，刺激因素刺激有机材料通过多个孔的生长。

公开(公告)号：US20140012122A1

公开(公告)日：2014-01-09

申请号：US13938156

申请日：2013-07-09

Applicant: California Institute of Technology

Inventor： Akram Sarwat Sadek ,  Axel Scherer ,  Muhammad Mujeeb-U-Rahman

IPC: A61B5/00

CPC classification number: A61B5/6846 ,  A61B5/14503 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/686 ,  A61B5/6876 ,  A61B2562/028 ,  A61B2562/14 ,  A61B2562/164

Abstract: An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more sensors on the chip layer and coupled to the power source and a hydrogel matrix including one or more angiogenesis stimulating factors in contact with the chip layer. The stimulating factors stimulate growth of organic material through the plurality of holes when the biosensor is implanted in a subject.

Abstract translation: 本文描述了可植入的生物相容性生物传感器。 生物传感器包括芯片层，其包括垂直于其上形成的多个孔，电源，芯片层上的一个或多个传感器并耦合到电源，以及水凝胶基质，其包括与芯片接触的一个或多个血管生成刺激因子 层。 当将生物传感器植入受试者时，刺激因素刺激有机材料通过多个孔的生长。