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    Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
    13.
    发明授权
    Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
    羧酸化合物和含有与活性成分相同的药物组合物

    公开(公告)号：US08138335B2

    公开(公告)日：2012-03-20

    申请号：US12551860

    申请日：2009-09-01

    申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

    发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

    IPC分类号： C07D265/36 ,  A61K31/535

    CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

    摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

    摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

    Method for producing optionally substituted methylenedioxybenzene
    15.
    发明授权
    Method for producing optionally substituted methylenedioxybenzene 有权
    制备任选取代的亚甲二氧基苯的方法

    公开(公告)号：US07847110B2

    公开(公告)日：2010-12-07

    申请号：US11587293

    申请日：2005-04-19

    申请人： Roland Jacquot ,  Jean-Roger Desmurs

    发明人： Roland Jacquot ,  Jean-Roger Desmurs

    IPC分类号： C07D317/48

    CPC分类号： C07D317/50 ,  C07D317/46 ,  C07D317/48

    摘要： The invention relates to a method for producing optionally substituted methylenedioxybenzene. The invention particularly relates to the production of methylenedioxybenzene. The inventive production method is characterized by the fact that it involves the reaction of an optionally substituted catechol with an aldehyde in the presence of a solid acid catalyst selected among: a titanium silicalite and a zeolite that is doped with tin and/or titanium.

    摘要翻译： 本发明涉及一种生产任选取代的亚甲二氧基苯的方法。 本发明特别涉及亚甲二氧基苯的制备。 本发明的制备方法的特征在于它包括在选自以下的固体酸催化剂存在下任选取代的邻苯二酚与醛的反应：钛硅沸石和掺杂有锡和/或钛的沸石。