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公开(公告)号：US20210387991A1
公开(公告)日：2021-12-16
申请号：US17327044
申请日：2021-05-21
发明人： I. Robert Silverman , Changhua Liu
IPC分类号： C07D487/04 , A61K45/06
摘要： Disclosed is a JAK1 and/or JAK2 inhibitor of the following structural formula: or a pharmaceutically acceptable salt thereof. This invention also provides pharmaceutical compositions comprising a compound of Formula (I), optionally including additional therapeutic agents, and use in methods of treatment for hair loss disorders.
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公开(公告)号：US20210330674A1
公开(公告)日：2021-10-28
申请号：US17118050
申请日：2020-12-10
IPC分类号： A61K31/519 , C07D487/04 , A61K45/06 , A61K31/4045 , A61K31/454 , A61K31/5685 , A61K31/7068
摘要： The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.
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公开(公告)号：US09655895B2
公开(公告)日：2017-05-23
申请号：US15148568
申请日：2016-05-06
IPC分类号： A61K31/485 , C07D221/28 , A61K45/06 , A61K31/195 , A61K31/4709
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
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![Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof](/abs-image/US/2016/04/19/US09315483B2/abs.jpg.150x150.jpg)
公开(公告)号：US09315483B2
公开(公告)日：2016-04-19
申请号：US14340143
申请日：2014-07-24
IPC分类号： C07D317/46 , C07D317/48 , C07D405/12 , C07D471/14 , C07D491/14
CPC分类号： C07D317/46 , C07D317/48 , C07D405/12 , C07D471/14 , C07D491/14
摘要： The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
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公开(公告)号：US08916582B2
公开(公告)日：2014-12-23
申请号：US14208968
申请日：2014-03-13
IPC分类号： A61K31/485 , C07D221/28 , A61P35/00 , A61P27/06 , A61P25/04
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
摘要翻译： 本发明涉及新的吗啡喃化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用也具有NMDA拮抗剂活性的1受体激动剂有益治疗的疾病和病症的方法中的用途。
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公开(公告)号：US20190100484A1
公开(公告)日：2019-04-04
申请号：US16055407
申请日：2018-08-06
IPC分类号： C07C59/115 , C07C69/708 , C07C69/675 , A61K45/06 , C07C69/67 , C07C59/01 , A61K31/19 , C07B59/00 , C07C59/125 , A61K31/225 , A61K31/22
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
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公开(公告)号：US20190038618A1
公开(公告)日：2019-02-07
申请号：US16036164
申请日：2018-07-16
IPC分类号： A61K31/485 , A61K45/06 , A61K31/195 , A61K31/4709 , C07D221/28
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , A61P25/08 , A61P25/16 , A61P29/00 , C07B59/002 , C07D221/28 , C07D471/08
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
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公开(公告)号：US20160287579A1
公开(公告)日：2016-10-06
申请号：US15148568
申请日：2016-05-06
IPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a al receptor agonist that also has NMDA antagonist activity.
摘要翻译： 本发明涉及新的吗啡喃化合物及其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用也具有NMDA拮抗剂活性的α受体激动剂有益治疗的疾病和病症的方法中的用途。
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公开(公告)号：US20150073009A1
公开(公告)日：2015-03-12
申请号：US14546173
申请日：2014-11-18
IPC分类号： C07D221/28
CPC分类号： A61K31/485 , A61K31/195 , A61K31/4709 , A61K45/06 , C07D221/28
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
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公开(公告)号：US10406155B2
公开(公告)日：2019-09-10
申请号：US16036164
申请日：2018-07-16
IPC分类号： A61K31/485 , C07D221/28 , A61K45/06 , A61K31/195 , A61K31/4709 , C07D471/08 , A61P25/16 , A61P29/00 , A61P25/08 , C07B59/00
摘要： This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
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