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    Phenanthrene methanol compounds useful as antimalarial agents
    11.
    发明授权
    Phenanthrene methanol compounds useful as antimalarial agents 失效
    菲甲醇化合物可用作抗疟剂

    公开(公告)号：US5250734A

    公开(公告)日：1993-10-05

    申请号：US889407

    申请日：1992-05-28

    Applicant: Jean-Francois Rossignol ,  Michael E. Randazzo

    Inventor： Jean-Francois Rossignol ,  Michael E. Randazzo

    IPC: C07C215/30 ,  C07C215/16

    CPC classification number: C07C215/30 ,  C07C2103/26

    Abstract: A compound represented by the following formula (I): ##STR1## wherein R is hydrogen, methyl, ethyl, propyl, butyl, phenyl, CH.sub.2 CH(OH)CH.sub.3, CH.sub.2 CH(OH)CH(OH), CH.sub.2 CH.sub.2 CH.sub.2 -phenyl, or a group of the formula (CH.sub.2).sub.x -Ar, where x is 0 to 4 and Ar is a 6-membered ring from phenyl, pyridyl, cyclohexyl, or pyranyl, each of which may be substituted with a hydrophilic group(s), andX can be Cl, tartrate, oxalate, or quinate.

    Abstract translation: 由下式（I）表示的化合物：其中R是氢，甲基，乙基，丙基，丁基，苯基，CH 2 CH（OH）CH 3，CH 2 CH（OH）CH（OH），CH 2 CH 2 CH 2 - ，或式（CH2）x-Ar的基团，其中x为0至4，Ar为来自苯基，吡啶基，环己基或吡喃基的6-元环，其各自可以被亲水基团取代 ），X可以是Cl，酒石酸盐，草酸盐或季铵盐。

    Lipoxygenase inhibitors
    14.
    发明授权
    Lipoxygenase inhibitors 失效
    脂氧合酶抑制剂

    公开(公告)号：US5140047A

    公开(公告)日：1992-08-18

    申请号：US695115

    申请日：1991-05-03

    Applicant: Jerry L. Adams ,  Ravi S. Garigipati

    Inventor： Jerry L. Adams ,  Ravi S. Garigipati

    IPC: C07C275/64 ,  C07D307/92

    CPC classification number: C07D307/92 ,  C07C275/64 ,  C07C2103/26

    Abstract: Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein.

    Abstract translation: 三环羟基脲和异羟肟酸酯化合物，药物组合物及其作为多不饱和脂肪酸氧化抑制剂的用途，例如通过抑制5-脂肪氧合酶，以及其中的疾病的治疗。

    Production of gem-disubstituted cyclohexadienones
    18.
    发明授权
    Production of gem-disubstituted cyclohexadienones 失效
    偕二取代的环己二烯酮的生产

    公开(公告)号：US4845258A

    公开(公告)日：1989-07-04

    申请号：US177153

    申请日：1988-04-04

    Applicant: G. Patrick Stahly

    Inventor： G. Patrick Stahly

    IPC: C07C37/62 ,  C07C39/24 ,  C07C45/62 ,  C07C45/67 ,  C07C49/497 ,  C07C49/713 ,  C07C49/747 ,  C07F7/08 ,  C07F7/18

    CPC classification number: C07F7/1856 ,  C07C37/50 ,  C07C45/62 ,  C07C45/673 ,  C07C49/497 ,  C07C49/713 ,  C07C49/747 ,  C07F7/0818 ,  C07C2103/24 ,  C07C2103/26

    Abstract: Quinones may be perfluoroalkylated by means of perfluoroalkyltrihydrocarbyl silane using quaternary ammonium bifluorides, quaternary phosphonium bifluorides or alkali metal bifluorides as catalysts. The reaction--which is conducted under essentially anhydrous conditions, preferably in a suitable liquid phase reaction medium, most preferably a dipolar aprotic solvent--results in the formation of gem-disubstituted cyclohexadienones in which the gem substituents are a perfluoroalkyl group and a trihydrocarbylsiloxy group. These gem-disubstituted compounds in turn can be readily converted to perfluoroalkyl substituted aromatics, thus circumventing the traditional need for photochlorination followed by halogen exchange using hydrogen fluoride as a means of preparing perfluoroalkyl aromatic compounds.

    Abstract translation: 醌类可以通过全氟烷基三烃基硅烷全氟烷基化，使用二氟化二氟鎓，二氟化鏻二氟化物或碱金属二氟化物作为催化剂。 在基本上无水条件下进行的反应，优选在合适的液相反应介质中，最优选偶极非质子溶剂进行，导致形成偕二取代的环己二烯酮，其中偕取代基是全氟烷基和三烃基甲硅烷氧基。 甲基二取代的化合物又可以容易地转化为全氟烷基取代的芳族化合物，从而避免了光氯化的传统需要，随后使用氟化氢进行卤素交换作为制备全氟烷基芳族化合物的手段。

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