公开(公告)号：US11180482B2

公开(公告)日：2021-11-23

申请号：US16465073

申请日：2017-11-29

Applicant: Ariad Pharmaceuticals, Inc.

Inventor： Wei-Sheng Huang ,  Yun Zhang ,  Willmen Youngsaye ,  Xiaotian Zhu ,  Erin Geno

IPC: C07D403/12 ,  C07D403/14 ,  C07D239/48 ,  C07D401/12 ,  C07D405/14 ,  C07D455/04

Abstract: The invention relates to HPK1 inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: where A, R1, R2, R3, R4, R5, R6, R16, R17, X1, X2, X3, X4, m, and n are described herein.

公开(公告)号：US10961214B2

公开(公告)日：2021-03-30

申请号：US16064276

申请日：2016-12-20

Applicant: Erik de Leeuw ,  Alexander MacKerell ,  Steven Fletcher ,  Jamal Chauhan

Inventor： Erik de Leeuw ,  Alexander MacKerell ,  Steven Fletcher ,  Jamal Chauhan

IPC: C07D309/34 ,  A61P31/04 ,  A61K31/35 ,  C07D455/04 ,  C07D405/06 ,  C07D403/06 ,  C07D471/06

Abstract: Newly synthesized derivatives of BAS00127538 have been discovered to possess antibiotic activity and to combat resistant bacterial strains. Compounds and pharmaceutical compositions containing these compounds are described, and are based on a generic scaffold structure. Synthetic methods and methods of using the compounds also are described. Preferred compound 6jc48-1 ((E)-2,4-bis(4-bromophenyl)-6-(4-(dimethyl-amino)styryl)pyrylium boron tetrafluoride salt) binds to Lipid II with high affinity, has markedly reduced cytotoxicity than BAS00127538, and retains activity against drug-resistant strains of Enterococci. It is stable in plasma, has dramatically improved pharmacokinetic and pharmacodynamics properties, and possesses in vivo efficacy in a mouse model of sepsis.

公开(公告)号：US10285969B2

公开(公告)日：2019-05-14

申请号：US15619936

申请日：2017-06-12

Applicant: CHANGZHOU DEZE MEDICAL SCIENCE CO., LTD ,  Houlei Teng ,  Wei Wu

Inventor： Houlei Teng ,  Wei Wu ,  Jingzhuo Zhang ,  Zhe Lin

IPC: C07D407/02 ,  C07D407/04 ,  C07D455/03 ,  A61K31/352 ,  A61K31/4375 ,  A61K9/00 ,  A61K9/20 ,  C07D455/04 ,  A61K9/06 ,  A61K9/16 ,  A61K9/19 ,  A61K9/48 ,  A61P3/00

Abstract: The present invention provides a mangiferin-6-O-berberine salt and a preparation method thereof, and further provides a use of the mangiferin-6-O-berberine salt for the treatment of diabetics and other diseases as an AMPK activator.

公开(公告)号：US20170273940A1

公开(公告)日：2017-09-28

申请号：US15619936

申请日：2017-06-12

Applicant: Houlei Teng ,  Wei Wu ,  CHANGZHOU DEZE MEDICAL SCIENCE CO., LTD

Inventor： Houlei TENG ,  Wei Wu ,  Jingzhuo Zhang ,  Zhe Lin

IPC: A61K31/352 ,  A61K9/20 ,  C07D407/04 ,  A61K9/00 ,  A61K31/4375 ,  C07D455/04

CPC classification number: A61K31/352 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/20 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/4375 ,  A61P3/00 ,  C07D407/04 ,  C07D455/03 ,  C07D455/04

Abstract: The present invention provides a mangiferin-6-O-berberine salt and a preparation method thereof, and further provides a use of the mangiferin-6-O-berberine salt for the treatment of diabetics and other diseases as an AMPK activator.

公开(公告)号：US20120214990A1

公开(公告)日：2012-08-23

申请号：US13463434

申请日：2012-05-03

Applicant: Taro KIYOTO ,  Tadashi Tanaka ,  Yasuhiro Tsutsui ,  Junichi Ando ,  Mai Motono ,  Yasuko Kawaguchi ,  Toshiya Noguchi ,  Yasunobu Ushiki ,  Fumihito Ushiyama ,  Hiroki Urabe

Inventor： Taro KIYOTO ,  Tadashi Tanaka ,  Yasuhiro Tsutsui ,  Junichi Ando ,  Mai Motono ,  Yasuko Kawaguchi ,  Toshiya Noguchi ,  Yasunobu Ushiki ,  Fumihito Ushiyama ,  Hiroki Urabe

IPC: C07D405/14 ,  C07D491/056 ,  C07D413/14 ,  C07D417/14 ,  C07D513/04 ,  C07D498/04 ,  C07D471/04 ,  C07D401/06 ,  C07D495/04 ,  C07D401/14 ,  C07D405/12 ,  C07D215/22 ,  C07D409/14 ,  C07D455/04

CPC classification number: C07D405/14 ,  C07D215/227 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00

Abstract: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Abstract translation: 由通式表示的含氮杂环化合物或其药学上可接受的盐，其具有强的抗菌活性和高安全性。 因此，这些化合物可用作抗革兰氏阳性细菌，革兰氏阴性细菌和耐药细菌的抗菌剂。

公开(公告)号：US20110233477A1

公开(公告)日：2011-09-29

申请号：US13073251

申请日：2011-03-28

Applicant: Hiroshi Yamamoto ,  Shinji Nakamichi ,  Junichi Tanabe ,  Ryuichi Takahashi ,  Hitoshi Yamato

Inventor： Hiroshi Yamamoto ,  Shinji Nakamichi ,  Junichi Tanabe ,  Ryuichi Takahashi ,  Hitoshi Yamato

IPC: H01L31/0224 ,  C07D401/14 ,  C07D213/80 ,  C07D401/10 ,  C07D455/04 ,  C07D413/10 ,  C07D401/06 ,  H01B1/22

CPC classification number: C07D213/80 ,  C07D213/38 ,  C07D213/65 ,  C07D213/89 ,  C07D401/06 ,  C07D401/14 ,  C07D455/04 ,  C09B23/148 ,  C09B57/00 ,  C09B57/008 ,  H01G9/2031 ,  H01G9/2059 ,  H01L51/0067 ,  Y02E10/542 ,  Y02E10/549

Abstract: The present invention pertains to an electrode layer comprising a porous film made of oxide semiconductor fine particles sensitized with certain methine dyes. Moreover the present invention pertains to a photoelectric conversion device comprising said electrode layer, a dye sensitized solar cell comprising said photoelectric conversion device and to novel dyes of formula (I)

Abstract translation: 本发明涉及包含由某些次甲基染料致敏的氧化物半导体微粒制成的多孔膜的电极层。 此外，本发明涉及包括所述电极层，包含所述光电转换装置的染料敏化太阳能电池和式（I）的新型染料的光电转换装置，

公开(公告)号：US07790739B2

公开(公告)日：2010-09-07

申请号：US12083745

申请日：2006-10-18

Applicant: Jongwon Lim ,  Ana Esther Gabarda Ortega

Inventor： Jongwon Lim ,  Ana Esther Gabarda Ortega

IPC: A61K31/44 ,  C07D455/04 ,  C07D413/00

CPC classification number: C07D495/14 ,  C07D471/04 ,  C07D491/04 ,  C07D491/14 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Abstract translation: 本发明涉及咪唑并[1,2-a]嘧啶衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

公开(公告)号：US20100009985A1

公开(公告)日：2010-01-14

申请号：US12437138

申请日：2009-05-07

Applicant: Santosh C. SINHA ,  Smita S. BHAT ,  Ken CHOW ,  Richard L. BEARD ,  John E. DONELLO ,  Michael E. GARST

Inventor： Santosh C. SINHA ,  Smita S. BHAT ,  Ken CHOW ,  Richard L. BEARD ,  John E. DONELLO ,  Michael E. GARST

IPC: A61K31/4375 ,  C07D455/04 ,  A61K31/5377 ,  A61P25/00 ,  A61P9/00

CPC classification number: C07D471/04 ,  C07D471/06

Abstract: Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.

Abstract translation: 本文公开了由结构式表示的化合物：还公开了与之相关的治疗方法，组合物和药物。

公开(公告)号：US20060014747A1

公开(公告)日：2006-01-19

申请号：US11218423

申请日：2005-09-06

Applicant: Martin Krueger ,  Andreas Huth ,  Orlin Petrov ,  Dieter Seidelmann ,  Karl-Heinz Thierauch ,  Martin Haberey ,  Andreas Menrad ,  Alexander Ernst

Inventor： Martin Krueger ,  Andreas Huth ,  Orlin Petrov ,  Dieter Seidelmann ,  Karl-Heinz Thierauch ,  Martin Haberey ,  Andreas Menrad ,  Alexander Ernst

IPC: C07D455/04 ,  C07D405/02 ,  A61K31/502

CPC classification number: C07D213/38

Abstract: Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described.

Abstract translation: 描述了邻位取代的邻氨基苯甲酸酰胺及其作为用于治疗由持续性血管生成触发的疾病的药物的用途。

公开(公告)号：US06936325B2

公开(公告)日：2005-08-30

申请号：US10102168

申请日：2002-03-20

Applicant: Horst Berneth ,  Friedrich-Karl Bruder ,  Wilfried Haese ,  Rainer Hagen ,  Karin Hassenrück ,  Serguei Kostromine ,  Peter Landenberger ,  Rafael Oser ,  Thomas Sommermann ,  Josef-Walter Stawitz ,  Thomas Bieringer ,  Yuichi Sabi ,  Takashi Iwamura ,  Mitsuaki Oyamada ,  Hidetoshi Watanabe ,  Sakuya Tamada ,  Masanobu Yamamoto

Inventor： Horst Berneth ,  Friedrich-Karl Bruder ,  Wilfried Haese ,  Rainer Hagen ,  Karin Hassenrück ,  Serguei Kostromine ,  Peter Landenberger ,  Rafael Oser ,  Thomas Sommermann ,  Josef-Walter Stawitz ,  Thomas Bieringer ,  Yuichi Sabi ,  Takashi Iwamura ,  Mitsuaki Oyamada ,  Hidetoshi Watanabe ,  Sakuya Tamada ,  Masanobu Yamamoto

IPC: B41M5/26 ,  C07D217/14 ,  C07D221/04 ,  C07D311/12 ,  C07D311/80 ,  C07D405/04 ,  C07D455/04 ,  C07D491/04 ,  C07F15/06 ,  C09B23/01 ,  C09B23/04 ,  C09B23/10 ,  C09B29/00 ,  C09B29/036 ,  C09B29/36 ,  C09B44/10 ,  C09B47/04 ,  C09B47/08 ,  C09B47/26 ,  C09B67/02 ,  C09B69/02 ,  C09K9/02 ,  G11B7/0045 ,  G11B7/007 ,  G11B7/24 ,  G11B7/244 ,  G11B7/246 ,  G11B7/2467 ,  G11B7/2472 ,  G11B7/248 ,  G11B7/249 ,  G11B7/253 ,  G11B7/2534 ,  G11B7/2542 ,  G11B7/257 ,  G11B7/2578 ,  G11B7/258 ,  G11B7/259 ,  G11B7/26 ,  B32B3/02

CPC classification number: C07D221/04 ,  C07D217/14 ,  C07D311/12 ,  C07D311/80 ,  C07D405/04 ,  C07D455/04 ,  C07D491/04 ,  C07F15/065 ,  C09B23/0091 ,  C09B23/04 ,  C09B23/105 ,  C09B29/0029 ,  C09B29/0074 ,  C09B29/36 ,  C09B44/10 ,  C09B47/045 ,  C09B47/085 ,  C09B47/26 ,  C09B67/0097 ,  C09B69/02 ,  C09K9/02 ,  G11B7/00455 ,  G11B7/007 ,  G11B7/00718 ,  G11B7/24 ,  G11B7/245 ,  G11B7/246 ,  G11B7/2467 ,  G11B7/2472 ,  G11B7/248 ,  G11B7/249 ,  G11B7/2534 ,  G11B7/2542 ,  G11B7/2578 ,  G11B7/259 ,  G11B7/26

Abstract: An optical recording medium having at least a recording layer 11 and a light transmitting layer 13 formed on a substrate 10, in which the recording layer 11 is made of an organic material for absorbing an incident light of wavelength of 360 nm to 460 nm, and inducing physical change or chemical change to vary the refractive index, the light transmitting layer 13 is 10 μm to 177 μm in thickness, the relation between absorption coefficient “k” and pyrolysis temperature Tdec of organic material is 950(° C.) 0.0.

Abstract translation: 一种至少具有记录层11和透光层13的光记录介质，其形成在基板10上，其中记录层11由用于吸收波长为360nm至460nm的入射光的有机材料制成，以及 引起物理变化或化学变化以改变折射率，透光层13的厚度为10μm至177μm，吸收系数“k”与有机材料的热解温度T dec之间的关系为 <？in-line-formula description =“在线公式”end =“lead”？> 950（°C）<（Tdec（°C。） - 20）/ k <4100°C（1） <？in-line-formula description =“In-line Formulas”end =“tail”？>，吸收系数“k”为k> 0.0。