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    Cationic tags for attomole level detection of analytes by mass spectrometry
    1.
    发明授权
    Cationic tags for attomole level detection of analytes by mass spectrometry 有权

    公开(公告)号：US10036743B2

    公开(公告)日：2018-07-31

    申请号：US15547588

    申请日：2016-02-01

    申请人： NORTHEASTERN UNIVERSITY

    发明人： Roger Giese ,  Poguang Wang

    IPC分类号： G01N33/52 ,  C07C217/48 ,  C07C217/58

    CPC分类号： G01N33/52 ,  C07C217/48 ,  C07C217/58 ,  G01N2458/15 ,  G01N2560/00

    摘要： The invention provides methods of detecting an analyte by multi-stage mass spectrometry with improved S/N ratio. An analyte is labeled with a positively-charged mass tag to form a precursor ion that leads by anchimeric assistance to a greatly enhanced, analyte-characteristic first product ion that can, in turn, lead to a greatly enhanced, analyte-characteristic second product ion in a mass spectrometer. Either a three stage mass spectrometer (true MS3) or a two-stage mass spectrometer (MS2) operated in a pseudo MS3 mode can be used. The precursor ion is split via an anchimeric-assisted reaction to form a first product ion, which in turn can be fragmented to form the second product ion. The methods offer extreme ultrasensitivity, at the low amol level. The invention also provides anchimeric mass tags for use in the methods. A wide variety of previously undetectable analytes of biological or environmental origin can be detected and quantified.

    Cationic Tags for Attomole Level Detection of Analytes by Mass Spectrometry
    2.
    发明申请
    Cationic Tags for Attomole Level Detection of Analytes by Mass Spectrometry 审中-公开

    公开(公告)号：US20180024123A1

    公开(公告)日：2018-01-25

    申请号：US15547588

    申请日：2016-02-01

    申请人： NORTHEASTERN UNIVERSITY

    发明人： Roger GIESE ,  Poguang WANG

    IPC分类号： G01N33/52 ,  C07C217/58 ,  C07C217/48

    CPC分类号： G01N33/52 ,  C07C217/48 ,  C07C217/58 ,  G01N2458/15 ,  G01N2560/00

    摘要： The invention provides methods of detecting an analyte by multi-stage mass spectrometry with improved S/N ratio. An analyte is labeled with a positively-charged mass tag to form a precursor ion that leads by anchimeric assistance to a greatly enhanced, analyte-characteristic first product ion that can, in turn, lead to a greatly enhanced, analyte-characteristic second product ion in a mass spectrometer. Either a three stage mass spectrometer (true MS3) or a two-stage mass spectrometer (MS2) operated in a pseudo MS3 mode can be used. The precursor ion is split via an anchimeric-assisted reaction to form a first product ion, which in turn can be fragmented to form the second product ion. The methods offer extreme ultrasensitivity, at the low amol level. The invention also provides anchimeric mass tags for use in the methods. A wide variety of previously undetectable analytes of biological or environmental origin can be detected and quantified.