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    HIGH SHEAR APPLICATION IN MEDICAL THERAPY
    13.
    发明申请
    HIGH SHEAR APPLICATION IN MEDICAL THERAPY 有权
    医疗治疗中的高剪切应用

    公开(公告)号：US20130096489A1

    公开(公告)日：2013-04-18

    申请号：US13441315

    申请日：2012-04-06

    Applicant: Abbas Hassan ,  Aziz Hassan ,  Rayford G. Anthony

    Inventor： Abbas Hassan ,  Aziz Hassan ,  Rayford G. Anthony

    IPC: A61M5/14

    CPC classification number: A61M5/1409 ,  A61K9/0019 ,  A61K9/0029 ,  A61K9/10 ,  A61K31/10 ,  A61K31/198 ,  A61K33/00 ,  A61K33/04 ,  A61K33/40 ,  A61K41/0004 ,  A61K45/06 ,  A61M5/1407 ,  A61M5/1408 ,  A61M2202/0208 ,  A61M2202/0216 ,  A61M2202/0233 ,  A61M2202/0241 ,  A61M2202/0266 ,  A61M2205/36 ,  A61M2206/16 ,  A61M2206/20 ,  B01F7/00766 ,  B01F13/1016 ,  A61K2300/00

    Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a therapeutic fluid, wherein said therapeutic fluid is a solution, a dispersion, or combination thereof and administering the produced therapeutic fluid intravenously to a patient; wherein the solution is supersaturated with the therapeutic gas, the therapeutic liquid, or combination thereof.

    Abstract translation: 在本公开中，描述了一种方法，其中所述方法包括在高剪切装置中混合治疗气体或治疗液体或其组合和液体载体以产生分散体; 并将产生的分散体静脉内施用于患者; 其中所制备的分散体含有平均直径小于约1.5μm的治疗液体的治疗气体或液滴的纳米气泡。 在本公开中，描述了一种方法，其中所述方法包括在高剪切装置中混合治疗气体或治疗液体或其组合和液体载体以产生治疗流体，其中所述治疗性流体是溶液，分散体， 或其组合，并将产生的治疗液静脉内施用于患者; 其中溶液用治疗气体，治疗液体或其组合过饱和。

    Systems And Methods For Ventilation To Obtain A Predetermined Patient Effort
    18.
    发明申请
    Systems And Methods For Ventilation To Obtain A Predetermined Patient Effort 审中-公开
    用于通气的系统和方法以获得预定的患者努力

    公开(公告)号：US20120167885A1

    公开(公告)日：2012-07-05

    申请号：US12980583

    申请日：2010-12-29

    Applicant: Milenko Masic ,  Peter Doyle

    Inventor： Milenko Masic ,  Peter Doyle

    IPC: A61M16/00

    CPC classification number: A61B5/087 ,  A61B5/08 ,  A61B5/7282 ,  A61B5/7292 ,  A61M16/0051 ,  A61M16/026 ,  A61M2016/0018 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2202/0208 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/15 ,  A61M2205/502 ,  A61M2230/005 ,  A61M2230/46

    Abstract: Various embodiments of the present disclosure provide systems, methods and devices for respiratory support. As one example, a ventilation system is disclosed that includes a computer readable medium including instructions executable by a processor to receive a measured pressure value and a net flow value. A patient effort value is calculated based on a relationship between patient effort, the measured pressure value and the net flow value. The instructions are further executable to calculate a gas delivery metric based on the computed patient effort to obtain a predetermined patient effort. Gas is then caused to be delivered consistent with the gas delivery metric.

    Abstract translation: 本公开的各种实施例提供用于呼吸支持的系统，方法和装置。 作为一个示例，公开了一种通风系统，其包括计算机可读介质，该计算机可读介质包括可由处理器执行以接收测量的压力值和净流量值的指令。 基于患者努力量，测量的压力值和净流量值之间的关系来计算患者努力值。 指令还可执行，以基于所计算的患者努力来计算气体输送量度以获得预定的患者努力。 然后使气体与气体输送量度一致。

    BROAD-BAND, LOW FREQUENCY, HIGH-AMPLITUDE, LONG TIME DURATION, OSCILLATING AIRWAY PRESSURE BREATHING APPARATUS AND METHOD UTILIZING BUBBLES
    20.
    发明申请
    BROAD-BAND, LOW FREQUENCY, HIGH-AMPLITUDE, LONG TIME DURATION, OSCILLATING AIRWAY PRESSURE BREATHING APPARATUS AND METHOD UTILIZING BUBBLES 有权
    宽带，低频，高功率，长时间，振荡气道呼吸装置和使用泡沫的方法

    公开(公告)号：US20110073112A1

    公开(公告)日：2011-03-31

    申请号：US12899177

    申请日：2010-10-06

    Applicant: Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    Inventor： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    IPC: A61M16/20

    CPC classification number: A61M16/0006 ,  A61M16/021 ,  A61M16/04 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/1045 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/003 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/3331 ,  A61M2205/3348 ,  A61M2205/3365 ,  A61M2205/50 ,  A61M2205/70

    Abstract: It has been discovered that high amplitude, low frequency, broadband spectrum pressure oscillations of sufficient time duration can help stabilize lung volumes and improve gas exchange in a patient receiving ventilation assistance by helping to recruit and stabilize alveoli. A novel device is presented which can produce pressure oscillations having high amplitudes, a low broad-band frequency spectrum and long time duration. Additionally, the device can maintain a patient's mean airway pressure at one or more controlled levels. The device can control the oscillatory amplitude, frequency range and composition, time duration, and mean airway pressure levels by adjusting certain device parameters, such as the angle and depth of the device in a fluid. A device and mechanical system for remotely adjusting and measuring the angle of the device in a fluid are also disclosed. Furthermore, a device and system are disclosed that can deliver pressure oscillations having high amplitudes, a low broad-band frequency spectrum, long time duration, and multiple mean airway inspiratory and expiratory pressure levels. The device and system also provide means for controlling respiration timing in a patient, including: breaths per minute, inspiratory time, and the ratio of inspiratory to expiratory time.

    Abstract translation: 已经发现，具有足够持续时间的高振幅，低频，宽带频谱压力振荡可以帮助稳定肺容积并通过帮助招募和稳定肺泡来改善患者接受通气辅助的气体交换。 提出了一种可以产生具有高幅度，低宽带频谱和长时间持续时间的压力振荡的新型装置。 另外，该装置可以将患者的平均气道压力维持在一个或多个受控水平。 该设备可以通过调整某些设备参数（例如流体中的设备的角度和深度）来控制振荡幅度，频率范围和组成，持续时间和平均气道压力水平。 还公开了用于远程调节和测量流体中装置的角度的装置和机械系统。 此外，公开了一种可以提供具有高幅度，低宽带频谱，长时间持续时间和多个平均气道吸气和呼气压力水平的压力振荡的装置和系统。 该装置和系统还提供用于控制患者呼吸时间的装置，包括：每分钟呼吸，吸气时间以及吸气与呼气时间的比例。

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