公开(公告)号：US20240358946A1

公开(公告)日：2024-10-31

申请号：US18579302

申请日：2022-07-18

Applicant: THORNHILL SCIENTIFIC INC.

Inventor： Joseph Arnold FISHER ,  James DUFFIN ,  Olivia SOBCZYK ,  Ece Su SAYIN ,  David J. MIKULIS ,  Julien POUBLANC ,  Jacob B. SCHULMAN

IPC: A61M16/00 ,  A61M16/12

CPC classification number: A61M16/024 ,  A61M16/12 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0266 ,  A61M2205/3303 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/505 ,  A61M2210/1039 ,  A61M2230/205

Abstract: The speed and range of the transition to low lung PO2 can be optimized such that it approaches the PO2 and timing profile of reoxygenation from a hypoxic profile. However, such hypoxic “spikes” are much more difficult to implement than re-oxygenation. A solution is to control the independent variables which contribute to hypoxia in the lung. These variables may be controlled in alone or in aggregate to minimize the time required to generate a target profile of transient lung hypoxia. In particular, a rapid decrease in [dOHb] can be implemented by breathing deeply, exhaling at least a portion of the functional residual capacity, lowering the PO2 at baseline, increasing the breathing rate, and increasing the PCO2 to shift the oxygen-hemoglobin dissociation curve to the right.

公开(公告)号：US11865255B2

公开(公告)日：2024-01-09

申请号：US17694563

申请日：2022-03-14

Applicant: Invent Medical Corporation

Inventor： Samuel M. Chang

IPC: A61M16/00 ,  A61M16/10 ,  A61M16/12 ,  A61M16/20

CPC classification number: A61M16/0066 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/026 ,  A61M16/1005 ,  A61M16/12 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/1055 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/0039 ,  A61M2016/1025 ,  A61M2202/0208 ,  A61M2202/0241 ,  A61M2202/0266 ,  A61M2202/0291 ,  A61M2205/3331 ,  A61M2205/3355 ,  A61M2205/50 ,  A61M2205/7518 ,  A61M2230/04 ,  A61M2230/06 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  A61M2230/50 ,  A61M2230/30 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/005 ,  A61M2230/205 ,  A61M2230/005 ,  A61M2230/10 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/005 ,  A61M2230/50 ,  A61M2230/005 ,  A61M2230/432 ,  A61M2230/005

Abstract: A ventilator is configured to supply a gas mixture to the lungs of a subject. The gas mixture comprises a first gas (e.g. oxygen) and a second gas (e.g. ambient air). The ventilator comprise a first gas inlet, a second gas inlet, flow modulator of the first gas, a flow modulator of the second gas, a junction configured to mix the first gas and the second gas, a patient interface configured to deliver the gas mixture to a subject, a pressure sensor, a plurality of flow sensors comprising at least a first flow sensor and a second flow sensor, and at least one controller configured for obtaining data from the pressure sensor and flow sensors and controlling the flow modulators to provide a gas mixture having a target pressure and a target oxygen content.

公开(公告)号：US11793968B2

公开(公告)日：2023-10-24

申请号：US17228510

申请日：2021-04-12

Applicant: Jerome Canady Research Institute for Advanced Biological and Technological Sciences

Inventor： Jerome Canady ,  Taisen Zhuang ,  Xiaoqian Cheng ,  Evgueni Sokolovski ,  Saravana Murthy ,  Buddika Sumanasena ,  Feng Yan ,  Cheffran Canady ,  Jerome McQueen

IPC: A61M16/14 ,  A61M16/10 ,  A61M16/00 ,  A61M16/06 ,  A61B18/04 ,  A61M16/16 ,  A61M16/12 ,  A61M16/04

CPC classification number: A61M16/14 ,  A61M16/022 ,  A61M16/024 ,  A61M16/0666 ,  A61M16/109 ,  A61B18/042 ,  A61M16/04 ,  A61M16/06 ,  A61M16/12 ,  A61M16/16 ,  A61M2202/025 ,  A61M2202/0208 ,  A61M2202/0266

Abstract: A method for performing cold atmospheric plasma treatment of respiratory infections or lung cancer having a source of a carrier gas, a cold atmospheric plasma generator connected to the source of carrier gas, a source of compressed air, a humidifier connected to the source of compressed air, a source of oxygen, a ventilator having inputs connected to an output of the humidifier and the source of oxygen, a mixer having an interior chamber formed from a dielectric, an active electrode inside the interior chamber, and an outer electrode connected to ground, wherein the mixer has a fluid input port connected to a gas output of the cold atmospheric plasma generator and an output of the ventilator, and a delivery member connected to an output of the mixer for delivering combined humidified air and cold atmospheric plasma to a respiratory system of a patient.

公开(公告)号：US09884162B2

公开(公告)日：2018-02-06

申请号：US14422458

申请日：2013-09-19

Applicant: Teijin Pharma Limited

Inventor： Sumihiro Kobayashi ,  Hisashi Kiriake

IPC: A61M16/10 ,  A61M16/00 ,  A61M16/20 ,  B01D53/047 ,  B01D53/30

CPC classification number: A61M16/101 ,  A61M16/0003 ,  A61M16/0063 ,  A61M16/107 ,  A61M16/20 ,  A61M2016/0027 ,  A61M2016/1025 ,  A61M2202/0208 ,  A61M2202/0266 ,  A61M2205/3331 ,  B01D53/047 ,  B01D53/30 ,  B01D2253/108 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2259/40007 ,  B01D2259/40052 ,  B01D2259/402 ,  B01D2259/4533

Abstract: An oxygen concentration device is provided which, when the number of revolutions of a compressor reaches an upper limit of control, increases an oxygen concentration, and can extend an operating time of the oxygen concentration device, comprising a control means which controls the number of revolutions of the compressor based on a detected value of an oxygen concentration sensor, judges deterioration due to moisture absorption based on the detected value of the oxygen concentration sensor, a detected value of a pressure sensor, and an operating time of an adsorption cylinder and, when criteria for judgment of the deterioration due to moisture absorption are satisfied, makes a purge step time shorter than an initially set time.

公开(公告)号：US20170312474A1

公开(公告)日：2017-11-02

申请号：US15260255

申请日：2016-09-08

Applicant: Tania Forde

Inventor： Tania Forde

IPC: A61M16/14 ,  A61M16/20 ,  A61M15/00 ,  A61K47/44 ,  A61K9/00 ,  A61M16/10 ,  A61K36/185 ,  A61K31/352 ,  A61K31/05 ,  A61K47/10 ,  A61K47/12

CPC classification number: A61M16/14 ,  A61K9/007 ,  A61K31/05 ,  A61K31/192 ,  A61K31/352 ,  A61K31/353 ,  A61K36/185 ,  A61K47/10 ,  A61M11/042 ,  A61M15/0003 ,  A61M16/0672 ,  A61M16/101 ,  A61M16/16 ,  A61M2202/0208 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2202/0283 ,  A61M2202/0468 ,  A61M2202/0007

Abstract: The ingestible compositions system includes the co-production of orally-ingestible compositions usable as inhalable respiratory agents including delivery apparatus and related methods.

公开(公告)号：US20160287824A1

公开(公告)日：2016-10-06

申请号：US15087522

申请日：2016-03-31

Applicant: Invent Medical Corporation

Inventor： Samuel M. Chang

IPC: A61M16/00 ,  A61M16/12 ,  A61M16/04 ,  A61M16/20 ,  A61M16/06 ,  A61M16/10 ,  A61M16/08

CPC classification number: A61M16/0066 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/026 ,  A61M16/1005 ,  A61M16/1055 ,  A61M16/12 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/0039 ,  A61M2016/1025 ,  A61M2202/0208 ,  A61M2202/0241 ,  A61M2202/0266 ,  A61M2202/0291 ,  A61M2205/3331 ,  A61M2205/3355 ,  A61M2205/50 ,  A61M2205/7518 ,  A61M2230/04 ,  A61M2230/06 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  A61M2230/50 ,  A61M2230/005

Abstract: This invention provides ventilators that provide superior air-oxygen mixing and gas delivery. The ventilators that supply a gas mixture to the lungs of a subject. The gas mixture comprises a first gas (e.g. oxygen) and a second gas (e.g. ambient air). The ventilators comprise a first gas inlet, a second gas inlet, flow modulator of the first gas, a flow modulator of the second gas, a junction configured to mix the first gas and the second gas, a patient interface configured to deliver the gas mixture to a subject, a pressure sensor, a plurality of flow sensors comprising at least a first flow sensor and a second flow sensor, and at least one controller configured for obtaining data from the pressure sensor and flow sensors and controlling the flow modulators to provide a gas mixture having a target pressure and a target oxygen content.

Abstract translation: 本发明提供了提供优异的空气 - 氧气混合和气体输送的换气机。 将气体混合物供应到受试者的肺部的呼吸机。 气体混合物包括第一气体（例如氧）和第二气体（例如环境空气）。 通风机包括第一气体入口，第二气体入口，第一气体的流量调节器，第二气体的流量调节器，被配置为混合第一气体和第二气体的接合部，被配置为输送气体混合物的患者接口 主体，压力传感器，至少包括第一流量传感器和第二流量传感器的多个流量传感器，以及至少一个控制器，被配置为从压力传感器和流量传感器获取数据并控制流量调节器以提供 具有目标压力和目标氧含量的气体混合物。

公开(公告)号：US09199026B2

公开(公告)日：2015-12-01

申请号：US13346321

申请日：2012-01-09

Applicant: David G. Greenberg ,  Scott Puritz ,  Tatiana Koutchma ,  Juan N. Walterspiel

Inventor： David G. Greenberg ,  Scott Puritz ,  Tatiana Koutchma ,  Juan N. Walterspiel

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61K35/14 ,  A61N5/00 ,  A61M1/32

CPC classification number: A61M1/3672 ,  A61K35/14 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1698 ,  A61M1/32 ,  A61M1/36 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/3633 ,  A61M1/3678 ,  A61M1/3681 ,  A61M1/3683 ,  A61M1/3686 ,  A61M1/3687 ,  A61M1/369 ,  A61M1/3693 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0233 ,  A61M2202/025 ,  A61M2202/0258 ,  A61M2202/0266 ,  A61M2202/0275 ,  A61M2202/0291 ,  A61M2202/20 ,  A61M2205/05 ,  A61M2205/053 ,  A61M2205/75 ,  A61N5/00 ,  G01N33/5091 ,  G01N2800/26

Abstract: Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

Abstract translation: 用于治疗受试者血液传播疾病或用于开发药物治疗血液传播疾病的体外系统和方法包括可针对特定疾病或感染而定制的各种环境和治疗模块。 在系统和方法的某些实施方案中，在对治疗有效的环境条件下，用静水压力，脉冲电场，药剂，微波，离心，超声处理，辐射或其组合处理血液样品。

公开(公告)号：US20150250960A1

公开(公告)日：2015-09-10

申请号：US14427716

申请日：2013-09-12

Applicant: Maquet Critical Care AB

Inventor： Stefan Broberg ,  Jacob Jansson ,  Hans Bocké

IPC: A61M16/00 ,  A61M16/10 ,  A61M16/08

CPC classification number: A61M16/0003 ,  A61M16/0057 ,  A61M16/0093 ,  A61M16/01 ,  A61M16/0891 ,  A61M16/1015 ,  A61M16/104 ,  A61M16/12 ,  A61M16/18 ,  A61M16/208 ,  A61M16/22 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2016/0033 ,  A61M2016/1025 ,  A61M2016/1035 ,  A61M2202/0007 ,  A61M2202/0208 ,  A61M2202/0241 ,  A61M2202/0266 ,  A61M2205/15 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/59 ,  G06F19/3481 ,  G16H40/63

Abstract: A Volume Reflector indicator for an anesthesia system is disclosed. The anesthesia system includes a volume reflector (30), a breathing circuit (40), a processing unit (10), and a display (20) operatively connected to said processing unit (10), wherein said processing unit (10) is configured to provide a status indicator (50) on said display (20) for gas in said volume reflector (30), said status indicator (50) including a graphical representation of (51) an extent of a driving gas of said volume reflector (30) and/or a patient gas in said volume reflector (30), and/or (52) a flow of gas and a direction of said flow in said volume reflector (30), and/or (53) a waste gas flow out of said volume reflector (30) relative a fresh gas flow in said system (1), and/or (54) a re-breathing fraction (RBF), and/or (55) a balance between said fresh gas flow and patient uptake and/or leakage of gas from said breathing circuit.

Abstract translation: 公开了用于麻醉系统的体积反射器指示器。 麻醉系统包括体积反射器（30），呼吸电路（40），处理单元（10）和可操作地连接到所述处理单元（10）的显示器（20），其中所述处理单元（10）被配置 在所述显示器（20）上为所述体积反射器（30）中的气体提供状态指示器（50），所述状态指示器（50）包括（51）所述体积反射器（30）的驱动气体的程度的图形表示 ）和/或所述体积反射器（30）中的患者气体，和/或（52）所述体积反射器（30）中的气体流和所述流动方向，和/或（53）废气流出 相对于所述系统（1）中的新鲜气体流动，和/或（54）再呼吸分数（RBF），和/或（55）所述新鲜气体流和患者摄取之间的平衡，所述体积反射器 和/或从所述呼吸回路泄漏气体。

公开(公告)号：US20150231357A1

公开(公告)日：2015-08-20

申请号：US14623779

申请日：2015-02-17

Applicant: Board of Regents, The University of Texas System

Inventor： Hanzhang LU ,  Peiying Liu

IPC: A61M16/12 ,  A61M16/20 ,  A61M16/06 ,  A61M16/08 ,  A61B5/0205 ,  A61B5/1455

CPC classification number: A61M16/122 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/055 ,  A61B5/0816 ,  A61B5/0833 ,  A61B5/0836 ,  A61M16/0816 ,  A61M16/20 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0266 ,  A61M2230/432 ,  A61M2230/435

Abstract: Systems and methods for delivery of gas mixtures to humans inside an MRI scanner, including while monitoring and recording physiological parameters.

Abstract translation: 在MRI扫描仪内部向人类输送气体混合物的系统和方法，包括在监测和记录生理参数的同时。

公开(公告)号：US20150083126A1

公开(公告)日：2015-03-26

申请号：US14397456

申请日：2012-04-27

Applicant: David D. Rogers

Inventor： David D. Rogers

IPC: A61M16/16 ,  A61M16/04 ,  A61M16/20 ,  A61M16/10 ,  A61M16/12 ,  A61M16/00 ,  A61M16/06

CPC classification number: A61M16/161 ,  A61M16/0003 ,  A61M16/0057 ,  A61M16/026 ,  A61M16/04 ,  A61M16/06 ,  A61M16/0833 ,  A61M16/0875 ,  A61M16/0883 ,  A61M16/1045 ,  A61M16/1075 ,  A61M16/109 ,  A61M16/12 ,  A61M16/142 ,  A61M16/147 ,  A61M16/16 ,  A61M16/164 ,  A61M16/205 ,  A61M2016/0027 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/3327 ,  A61M2205/3368 ,  A61M2205/50

Abstract: A breathing circuit humidification system (200) is described that includes a humidification system (102) and a patient breathing circuit (201). The humidification system includes at least a moisture water source (209), a flash evaporator (211) and a moisture exchanger. Water is selectively introduced from the water source to the flash evaporator. The flash evaporator includes a heating element that evaporates the received water to form water vapor. The water vapor is sent to the moisture exchanger. The moisture exchanger receives gas from a gas source. The received gas is humidified with the water vapor received from the flash evaporator. The moisture exchanger sends the humidified gas to the patient breathing circuit. The patient breathing circuit provides, in a controlled manner, the humidified gas to a patient (106). Related methods, apparatus, systems, techniques and articles are also described.

Abstract translation: 描述了包括加湿系统（102）和患者呼吸回路（201）的呼吸回路加湿系统（200）。 加湿系统至少包括湿气源（209），闪蒸蒸发器（211）和湿气交换器。 水从水源选择性地引入闪蒸发生器。 闪蒸器包括一个加热元件，其使接收到的水蒸发以形成水蒸气。 水蒸气被送到湿气交换器。 湿气交换器接收来自气源的气体。 接收到的气体被从闪蒸器接收的水蒸汽加湿。 湿气交换器将加湿气体发送到患者呼吸回路。 患者呼吸回路以受控的方式提供加湿气体到患者（106）。 还描述了相关方法，装置，系统，技术和制品。