公开(公告)号：US20240389856A1

公开(公告)日：2024-11-28

申请号：US18694505

申请日：2022-09-29

Applicant: THORNHILL SCIENTIFIC INC.

Inventor： Jacob B. SCHULMAN ,  Kamil ULUDAG ,  Joseph Arnold FISHER ,  David MIKULIS ,  Olivia SOBCZYK ,  Ece Su SAYIN ,  Julien POUBLANC ,  James DUFFIN

IPC: A61B5/00 ,  A61B5/055

Abstract: Deoxyhemoglobin contrast has been used to locate arteries based on the earlier blood oxygen-level dependent (BOLD) signal arrival time, higher BOLD signal strength, and shorter mean transit time. However, additional strategies of identifying arteries with oxygen modulation are required to improve the sensitivity and specificity of results. The present disclosure provides a method of distinguishing extravascular voxels from intravascular voxels based on the magnetic signal obtained from two hypoxic boluses having two different baselines. Intravascular voxels are responsive to changes in the baseline due to their high blood volume, while extravascular voxels are not affected by changes to the baseline. Amongst intravascular voxels, arteries can be distinguished from veins because the extraction fraction of the arterial blood is reduced during hypoxia, and therefore veins are less sensitive to changes in the baseline.

公开(公告)号：US20240135558A1

公开(公告)日：2024-04-25

申请号：US18542450

申请日：2023-12-15

Applicant: THORNHILL SCIENTIFIC INC.

Inventor： Joseph FISHER ,  Olivia SOBCZYK ,  Adrian P. CRAWLEY ,  Julien POUBLANC ,  Kevin SAM ,  Daniel M. MANDELL ,  David MIKULIS ,  James DUFFIN

IPC: G06T7/38 ,  A61B5/00 ,  A61B5/026 ,  A61B5/145 ,  G06T7/00 ,  G06T7/11

CPC classification number: G06T7/38 ,  A61B5/0042 ,  A61B5/0263 ,  A61B5/14542 ,  G06T7/0012 ,  G06T7/11 ,  A61B5/055

Abstract: Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide suprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.

公开(公告)号：US20240358946A1

公开(公告)日：2024-10-31

申请号：US18579302

申请日：2022-07-18

Applicant: THORNHILL SCIENTIFIC INC.

Inventor： Joseph Arnold FISHER ,  James DUFFIN ,  Olivia SOBCZYK ,  Ece Su SAYIN ,  David J. MIKULIS ,  Julien POUBLANC ,  Jacob B. SCHULMAN

IPC: A61M16/00 ,  A61M16/12

CPC classification number: A61M16/024 ,  A61M16/12 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0266 ,  A61M2205/3303 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/505 ,  A61M2210/1039 ,  A61M2230/205

Abstract: The speed and range of the transition to low lung PO2 can be optimized such that it approaches the PO2 and timing profile of reoxygenation from a hypoxic profile. However, such hypoxic “spikes” are much more difficult to implement than re-oxygenation. A solution is to control the independent variables which contribute to hypoxia in the lung. These variables may be controlled in alone or in aggregate to minimize the time required to generate a target profile of transient lung hypoxia. In particular, a rapid decrease in [dOHb] can be implemented by breathing deeply, exhaling at least a portion of the functional residual capacity, lowering the PO2 at baseline, increasing the breathing rate, and increasing the PCO2 to shift the oxygen-hemoglobin dissociation curve to the right.

公开(公告)号：US20240335128A1

公开(公告)日：2024-10-10

申请号：US18579311

申请日：2022-07-18

Applicant: THORNHILL SCIENTIFIC INC.

Inventor： Joseph Arnold FISHER ,  James DUFFIN ,  Julien POUBLANC ,  Olivia SOBCZYK ,  David J. MIKULIS ,  Ece Su SAYIN

IPC: A61B5/026 ,  A61B5/00 ,  A61B5/055 ,  G01R33/56

CPC classification number: A61B5/0263 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/7257 ,  G01R33/5601 ,  A61B2576/026

Abstract: A method of implementing changes in deoxyhemoglobin concentration, the method comprising: targeting a sequence of partial pressures of oxygen in arterial blood (PaCh) values in a subject using a sequential gas delivery device in a periodic input pattern; measuring a blood-oxygen level dependent (BOLD) signal in a voxel of the subject's brain using a magnetic resonance imaging device while targeting the sequence of values; comparing the pattern to the signal; and determining a vascular tissue characteristic (vessel type, vessel orientation, or pathological condition) for the voxel based on the comparison.

公开(公告)号：US20250040840A1

公开(公告)日：2025-02-06

申请号：US18785732

申请日：2024-07-26

Applicant: THORNHILL SCIENTIFIC INC.

Inventor： Joseph Arnold FISHER ,  Olivia SOBCZYK ,  James DUFFIN ,  Julien POUBLANC ,  David J. MIKULIS ,  Ece Su SAYIN

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/055 ,  G01R33/50

Abstract: The present specification discloses a method for measuring brain tissue oxygenation in a subject. The method comprises the following steps: measuring a magnetic signal in a reference voxel of the subject's brain while imposing a series of arterial oxygen saturation changes using sequential gas delivery; calculating a relationship between the magnetic signal and the arterial oxygen saturation in the reference voxel; measuring a magnetic signal in a target voxel; and calculating the hemoglobin saturation in the target voxel based on the established relationship between the magnetic signal and the SaO2 in the reference voxel. This calibration of magnetic signal for SaO2 enables the conversion of magnetic signal to SaO2 throughout blood-containing voxels throughout the brain.

公开(公告)号：US20240285196A1

公开(公告)日：2024-08-29

申请号：US18572452

申请日：2022-06-21

Applicant: THORNHILL SCIENTIFIC INC

Inventor： David J. MIKULIS ,  Julien POUBLANC ,  Olivia SOBCZYK ,  James DUFFIN ,  Ece Su SAYIN ,  Joseph Arnold FISHER

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14551 ,  A61B5/0042

Abstract: Hypoxia-induced deoxy hemoglobin concentration ([dOHb]) may be used as a susceptibility contrast agent in subjects. While the maximal rate of generating blood [dOHb] are limited by constraints in pulmonary gas mixing, decreasing dOHb with reoxygenation of the lungs can be accomplished in one breath, resulting in a step reduction in arterial [dOHb] and thereby a step increase in cerebral BOLD signal recorded with MRI. The BOLD signal changes accompanying a step decrease in [dOHb] can be analyzed to calculate cerebral perfusion measures and compare their maps to those obtained using a bolus of a conventional contrast agent, gadolinium, and a conventional analysis requiring the identification of an arterial input function. The two methods provided comparable anatomically-distributed hemodynamic information.