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公开(公告)号：US20180259761A1
公开(公告)日：2018-09-13
申请号：US15872149
申请日：2018-01-16
Applicant: OLYMPUS CORPORATION
Inventor： Brendan BRINKMAN , Yoshihiro SHIMADA , Daisuke NISHIWAKI
CPC classification number: G02B21/33 , G01N21/6458 , G01N2021/6463 , G02B21/241
Abstract: An immersion liquid holder 2 is an immersion liquid holder that is used for an observation device 10 for observing sample S by using an immersion method, and includes a supporting member 2b configured to support an absorption member 3 that has absorbed an immersion liquid and a connection unit 2c configured to relatively fix the absorption member 3 that has absorbed the immersion liquid with respect to an optical system, which is an optical system included in the observation device 10, and to fix the absorption member 3 on an optical path of the optical system 1, by fixing the supporting member 2b to the observation device 10.
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公开(公告)号：US20220350126A1
公开(公告)日：2022-11-03
申请号：US17730154
申请日：2022-04-26
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA
Abstract: An inverted microscope apparatus includes an immersion objective, an electric stage that moves at least in a direction orthogonal to an optical axis of the immersion objective, and a removal mechanism that removes an immersion liquid adhering to a bottom surface of a container placed on the electric stage. The removal mechanism is configured to scan the bottom surface using movement of the electric stage.
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公开(公告)号：US20190146203A1
公开(公告)日：2019-05-16
申请号：US16186303
申请日：2018-11-09
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA , Kazuhito GODA
Abstract: Provided is a sample observation method including: bringing a gel-like transparent sample that encloses an observation target into contact with a transparent flat surface section of a substrate; and collecting light from the observation target by means of an objective lens via the substrate, in a state in which a pressing force is made to act in a direction in which the sample and the flat surface section relatively approach each other, until the contact area between the sample and the flat surface section comes to have a size allowing an effective light flux for the objective lens of a microscope to pass therethrough.
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公开(公告)号：US20180180867A1
公开(公告)日：2018-06-28
申请号：US15800908
申请日：2017-11-01
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA
CPC classification number: G02B21/364 , G02B21/025 , G02B21/06 , G02B21/18
Abstract: A microscope includes: a first illumination optical system that illuminates a sample from a first direction that is substantially orthogonal to an optical axis of a first objective, and that forms a first illumination region within the sample; a first imaging optical system that images the sample in accordance with light that has been generated from the first illumination region; a second illumination optical system that illuminates the sample from a second direction that is substantially orthogonal to the optical axis of the first objective; and a second imaging optical system that images the sample in accordance with light emitted from the second illumination optical system.
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公开(公告)号：US20170302827A1
公开(公告)日：2017-10-19
申请号：US15477282
申请日：2017-04-03
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA
CPC classification number: H04N5/04 , C12M41/36 , G01N15/1434 , G01N15/1436 , G01N15/147 , G01N2015/1006 , G01N2015/144 , G01N2015/1445 , G02B21/0032 , G02B21/0076 , G02B21/02 , G02B21/16 , G02B21/26 , G02B21/361 , G02B21/362
Abstract: In order to simply and accurately acquire a three-dimensional image of a sample to observe the sample, a light-sheet microscope according to the present invention includes: a duct in which the sample can flow; a syringe pump for moving the sample in the duct; a cylindrical lens for causing planar illumination light along a plane intersecting the direction in which the sample is moved by the syringe pump to enter the duct; an objective lens that is disposed so as to face the radiation plane of the illumination light caused by the cylindrical lens to enter the duct and that collects fluorescence emitted from the sample moved by the syringe pump so as to pass through the radiation plane of the illumination light; and a camera for acquiring an image of the fluorescence from the sample collected by the objective lens.
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Patent Agency Ranking
公开(公告)号：US20140376078A1
公开(公告)日：2014-12-25
申请号：US14298707
申请日：2014-06-06
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA , Makio UENO , Shingo TAMANO , Naoki HAYASHI , Eiji YOKOI
CPC classification number: G02B21/0032 , G02B21/002 , G02B21/0036 , G02B21/0096 , G02B21/06 , G02B21/26 , G02B27/4261
Abstract: A scanning optical microscope includes a light source, a light converging optical system, a stage, a scanning unit which displaces an illumination light and the stage relatively, a detecting optical system, and a photodetector. A light modulation element and a relay optical system are disposed on the light converging optical system side of the light source, and a modulated signal having only amplitude changed is input to the light modulation element, and the light modulation element is positioned such that the illumination light emerged from the light modulation element with respect to the modulated signal of a predetermined amplitude coincides with an optical axis of the light converging optical system, and a position of a pupil of the light converging optical system and a position of the light modulation element are conjugate through at least the relay optical system.
Abstract translation: 扫描光学显微镜包括光源，聚光光学系统，舞台，相对地移动照明光和舞台的扫描单元，检测光学系统和光电检测器。 光调制元件和中继光学系统设置在光源的聚光光学系统侧，并且只有振幅改变的调制信号被输入到光调制元件，并且光调制元件被定位成使得照明 相对于预定幅度的调制信号从光调制元件出射的光与会聚光学系统的光轴重合，会聚光学系统的光瞳位置和光调制元件的位置是 通过至少中继光学系统共轭。
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公开(公告)号：US20190310454A1
公开(公告)日：2019-10-10
申请号：US16370630
申请日：2019-03-29
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA
Abstract: A microscope includes a movable stage supporting wells arranged in an array, a first imaging unit having a low-magnification objective lens, a second imaging unit having a high-magnification objective lens, a computer determining a representative position of a spheroid based on imaging data of the spheroid acquired by the first imaging unit, and a controller causing respective imaging units to sequentially acquire imaging data of the spheroid in each of the wells. The controller causes the first imaging unit to acquire imaging data for the spheroid in one of the wells, and then causes the stage to adjust the representative position to the optical axis of the high-magnification objective lens, and further causes the second imaging unit to acquire imaging data while causing the first imaging unit to acquire imaging data of the spheroid in another of the wells in synchronization with acquisition by the second imaging unit.
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公开(公告)号：US20180164569A1
公开(公告)日：2018-06-14
申请号：US15828980
申请日：2017-12-01
Applicant: OLYMPUS CORPORATION
Inventor： Brendan BRINKMAN , Yoshihiro SHIMADA
CPC classification number: G02B21/34 , G01N21/6452 , G01N21/6458 , G01N2021/6478 , G02B21/06 , G02B21/10 , G02B21/16 , G02B21/26 , G02B21/361 , G02B27/30
Abstract: This microplate includes: container sections having wells that open at a first plane and that accommodate samples; and a connection section connecting a plurality of rows of the container sections to be arrayed in a manner where the rows are spaced from each other in a direction along the first plane, wherein each of the container sections includes: at least one side wall section that is optically transparent at at least a portion thereof; and a bottom surface section that is disposed on a second plane on a side opposite from the first plane and that is optically transparent at at least a portion thereof, a recessed section is provided between neighboring rows of the container sections, and the recessed section allows an optical member to be inserted thereinto via the second plane, wherein the optical member introduces sheet-shaped illumination light to the well via the side wall section.
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公开(公告)号：US20170261731A1
公开(公告)日：2017-09-14
申请号：US15436738
申请日：2017-02-17
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro SHIMADA , Yujin ARAI
Abstract: The present invention provides a light-field microscope including: an illumination optical system that radiates excitation light onto a sample; and a detection optical system including an objective lens that collects fluorescence generated in the sample as a result of the sample being irradiated with the excitation light by the illumination optical system, an image-acquisition element that acquires an image of the fluorescence collected by the objective lens, and a microlens array disposed between the image-acquisition element and the objective lens. The illumination optical system radiates a beam of the excitation light having a predetermined width in the optical-axis direction of the objective lens so as to include the focal plane of the objective lens onto the sample in a direction substantially perpendicular to the optical axis.
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公开(公告)号：US20160363748A1
公开(公告)日：2016-12-15
申请号：US15161997
申请日：2016-05-23
Applicant: OLYMPUS CORPORATION
Inventor： Hisao KITAGAWA , Yoshihiro SHIMADA , Kosuke TAKAGI
CPC classification number: G02B21/006 , G02B21/0028 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/26 , G02B21/34 , G02B21/367
Abstract: Provided is a microscope system including a motor-driven stage on which is mounted a culture vessel containing one or more cell clusters, each including cells having a target molecule labeled with a fluorescent or luminescent chemical; a low-magnification-image acquiring unit that acquires low-magnification images of the cell clusters in the culture vessel mounted on the stage; a detecting unit that detects the position of each cell cluster in the culture vessel by analyzing the acquired low-magnification images; and a high-magnification-image acquiring unit that, after the detected position is aligned with the optical axis of an objective lens, acquires slice images of fluorescence or luminescence emitted from the cells forming the cell cluster at a higher magnification than the low-magnification-image acquiring unit at intervals along the optical axis while the stage and/or the lens is moved to change stepwise the distance between the lens and the cell cluster.
Abstract translation: 提供了一种显微镜系统，其包括电动驱动平台，其上安装有包含一个或多个细胞簇的培养容器，每个细胞簇包括具有用荧光或发光化学品标记的靶分子的细胞; 低放大图像获取单元，其获取安装在所述台上的培养容器中的细胞簇的低倍率图像; 检测单元，其通过分析所获取的低倍率图像来检测培养容器中的每个细胞簇的位置; 以及高倍率图像获取单元，其在检测到的位置与物镜的光轴对准之后，以比低倍率更高的倍率获取从形成细胞簇的细胞发射的荧光或发光的切片图像 - 图像获取单元，沿着光轴间隔，同时移动台和/或透镜以逐步改变透镜和细胞簇之间的距离。
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