公开(公告)号：US20150223738A1

公开(公告)日：2015-08-13

申请号：US14621265

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Sameer WALAVALKAR ,  Chieh-feng CHANG ,  Axel SCHERER

IPC: A61B5/1459 ,  A61B5/07 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/076 ,  A61B5/14735 ,  A61B5/6848 ,  A61B5/686 ,  A61B2562/0285 ,  A61B2562/066 ,  A61B2562/12 ,  A61B2562/223 ,  B01J2219/00509 ,  B01J2219/0052 ,  B01J2219/00531 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/658

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

Abstract translation: 描述了纳米柱传感器的方法和系统。 纳米玻璃可以在基底上定义，金属沉积在纳米柱上。 热处理可以回流纳米柱上的金属，在纳米柱的顶端形成金属灯泡。 这些结构可以在用生物制剂进行功能化时具有增强的光学检测，或者可以通过与纳米柱上的金属层的相互作用来检测气体，颗粒和液体。

公开(公告)号：US20140336485A1

公开(公告)日：2014-11-13

申请号：US14340498

申请日：2014-07-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Muhammad MUJEEB-U-RAHMAN ,  Meisam HONARVAR NAZARI ,  Mehmet SENCAN ,  Axel SCHERER

IPC: A61B5/1473 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  B82Y10/00 ,  B82Y15/00 ,  G01N27/48 ,  H01L21/77 ,  H01L25/16 ,  H01L27/04 ,  H01L28/10 ,  H01L29/0676 ,  H01L29/413 ,  H01L2924/0002 ,  Y10T29/49018 ,  H01L2924/00

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract translation: 描述了完全集成的小尺寸植入式感测装置，其可以包括传感器和电子电路以与传感器接口并与外部设备通信。 描述了用于感测装置的各种制造方法，包括提供使用与电子电路相同的制造技术产生的孔，以容纳传感器的电极和相应的功能化学品。 这种植入式感测装置可以用于生物体内的各种电化学测量应用，以及通过将电流注入生物体来启动。

公开(公告)号：US20140319459A1

公开(公告)日：2014-10-30

申请号：US14329748

申请日：2014-07-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Andrew P. HOMYK ,  Michael D. HENRY ,  Axel SCHERER ,  Sameer WALAVALKAR

IPC: H01L29/06 ,  H01L31/0352 ,  H01L33/06

CPC classification number: H01L31/035227 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/0243 ,  H01L21/02521 ,  H01L21/0259 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0676 ,  H01L29/127 ,  H01L29/267 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/775 ,  H01L33/06 ,  Y10S977/762

Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Abstract translation: 描述了使用硅纳米线制造自对准异质结构和半导体布置的方法。

公开(公告)号：US20140096831A1

公开(公告)日：2014-04-10

申请号：US13840440

申请日：2013-03-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Emil P. KARTALOV ,  John LIU ,  Axel SCHERER ,  Clive TAYLOR

IPC: G05D7/06

CPC classification number: G05D7/0694 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/008 ,  Y10T137/0318 ,  Y10T137/218 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/7795 ,  Y10T137/7796

Abstract: Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.

Abstract translation: 描述了多瓣膜自动调节微流体装置和方法。 所描述的装置和方法提供改进的性能和调整微流体装置中的自动调节效应的新手段。

公开(公告)号：US20140057210A1

公开(公告)日：2014-02-27

申请号：US14070469

申请日：2013-11-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Imran R. MALIK ,  Axel SCHERER ,  Erika F. GARCIA ,  Xiomara L. MADERO

IPC: B01L3/00

CPC classification number: B01L3/52 ,  B01L3/502707 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2300/0654 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/0478 ,  B33Y80/00 ,  Y10T156/10

Abstract: Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber. The cartridge may also have handles to facilitate its use. Such cartridges may be used for polymerase chain reaction.

Abstract translation: 公开了制备用于生物样品制备和分析的反应柱的方法。 墨盒可以具有反应室和开口以允许流体进入腔室。 墨盒也可以具有便于使用的手柄。 这种药盒可用于聚合酶链反应。

公开(公告)号：US20140030819A1

公开(公告)日：2014-01-30

申请号：US13941295

申请日：2013-07-12

Applicant: SANOFI ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Chieh-feng CHANG ,  Oliver PLETTENBURG ,  Stefan PETRY ,  Axel SCHERER ,  Charles L. TSCHIRHART

IPC: H01L29/73 ,  H01L29/78

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。

公开(公告)号：US20140026413A1

公开(公告)日：2014-01-30

申请号：US14038702

申请日：2013-09-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Aditya RAJAGOPAL ,  Axel SCHERER

IPC: H05K3/10

CPC classification number: H05K3/10 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  H01L23/473 ,  H01L2924/0002 ,  H05K1/0272 ,  H05K3/284 ,  H05K2201/10189 ,  H05K2203/1327 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T137/85938 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575 ,  H01L2924/00

Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.

Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。

公开(公告)号：US20240167105A1

公开(公告)日：2024-05-23

申请号：US18419486

申请日：2024-01-22

Applicant: California Institute of Technology

Inventor： Aditya RAJAGOPAL ,  Mark D. GOLDBERG ,  Erika F. GARCIA ,  Xiomara L. MADERO ,  Thomas A. TOMBRELLO ,  Axel SCHERER

IPC: C12Q1/70 ,  C12Q1/68 ,  C12Q1/6851

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333

Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.

公开(公告)号：US20230258848A1

公开(公告)日：2023-08-17

申请号：US18091221

申请日：2022-12-29

Applicant: California Institute of Technology

Inventor： Taeyoon JEON ,  Axel SCHERER ,  Jack JEWELL

IPC: G02B5/08 ,  G02B1/113

CPC classification number: G02B5/0875 ,  G02B1/113 ,  G02B5/0883

Abstract: An optical-thin-film structure comprises a low-index optical thin film consisting essentially of co-deposited Barium Fluoride and a secondary fluoride compound, and a high-index optical thin film.

公开(公告)号：US20200278294A1

公开(公告)日：2020-09-03

申请号：US16803938

申请日：2020-02-27

Applicant: California Institute of Technology

Inventor： William M. JONES ,  Lucia B. DE ROSE ,  Axel SCHERER

IPC: G01N21/552

Abstract: Light detectors that combine field emission with light focusing by surface plasmon polaritons. Methods and devices that allow detection and measurement of light at high frequencies in the THz range are described. The disclosed devices include plasmonic metal contacts with a narrow nanometer-sized gap to couple an optical waveguide mode into a plasmonic mode thereby generating filed emission currents by biasing the contacts.