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公开(公告)号：US20140057210A1
公开(公告)日：2014-02-27
申请号：US14070469
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER , Erika F. GARCIA , Xiomara L. MADERO
IPC: B01L3/00
CPC classification number: B01L3/52 , B01L3/502707 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/0654 , B01L2300/0867 , B01L2300/0877 , B01L2400/0478 , B33Y80/00 , Y10T156/10
Abstract: Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber. The cartridge may also have handles to facilitate its use. Such cartridges may be used for polymerase chain reaction.
Abstract translation: 公开了制备用于生物样品制备和分析的反应柱的方法。 墨盒可以具有反应室和开口以允许流体进入腔室。 墨盒也可以具有便于使用的手柄。 这种药盒可用于聚合酶链反应。
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公开(公告)号：US20180052110A1
公开(公告)日：2018-02-22
申请号：US15701014
申请日：2017-09-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Xiomara Linnette MADERO , Erika F. GARCIA , Sheel Mukesh SHAH , Axel SCHERER
CPC classification number: G01N21/6486 , C12Q1/6851 , C12Q2537/143 , C12Q2537/165 , C12Q2565/629
Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.
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公开(公告)号：US20160151782A1
公开(公告)日：2016-06-02
申请号：US14963180
申请日：2015-12-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER
IPC: B01L3/00
CPC classification number: B01L3/502707 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0861 , B01L2300/0877 , B01L2300/0887 , B01L2300/16 , B29C65/486 , B32B3/02 , B32B3/30 , Y10T137/8593
Abstract: A fluidic device including a body having a surface and one or more channels located in the body. Recesses are defined on said surface. The one or more channels can have respective boundaries. A layer of adhesive including one or more panel-shaped pieces having a pattern based on the pattern of boundaries of the channels can be formed and applied on the surface of the body. It is further controlled that the layer of adhesive has respective boundaries surrounding the boundaries of the one or more channels.
Abstract translation: 一种流体装置，包括具有表面的主体和位于身体中的一个或多个通道。 凹槽被定义在所述表面上。 一个或多个通道可以具有相应的边界。 可以形成包括一个或多个基于通道边界图案的图案的一个或多个面板形件的粘合剂层，并施加到主体的表面上。 进一步控制粘合剂层具有围绕一个或多个通道的边界的相应边界。
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公开(公告)号：US20140127796A1
公开(公告)日：2014-05-08
申请号：US14070440
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER , Erika F. GARCIA , Xiomara L. MADERO
IPC: C12M1/40
CPC classification number: C12M21/18 , B01L3/0275 , B01L3/502707 , B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/04 , B01L2200/10 , B01L2200/147 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/1827 , B01L2400/0478
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。
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公开(公告)号：US20140036267A1
公开(公告)日：2014-02-06
申请号：US13947469
申请日：2013-07-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Xiomara L. MADERO , Erika F. GARCIA , Axel SCHERER
IPC: G01N21/64
CPC classification number: G01N21/64 , G01N21/0303 , G01N21/645
Abstract: Structures and methods are described for optical detection of physical, chemical and/or biological samples. An optical detection structure may include a LED source, multiple filters and single or multiple sample areas. A detector may be used to record a fluorescence signal. The sample area may allow the introduction of removable cartridges.
Abstract translation: 描述了物理，化学和/或生物样品的光学检测的结构和方法。 光学检测结构可以包括LED源，多个滤光器和单个或多个样品区域。 检测器可用于记录荧光信号。 样品区域可能允许引入可移除的墨盒。
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Patent Agency Ranking
公开(公告)号：US20140127790A1
公开(公告)日：2014-05-08
申请号：US14070454
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Erika F. GARCIA , Xiomara Linnette MADERO , Axel SCHERER
IPC: C12Q1/68
CPC classification number: C12M21/18 , B01L3/0275 , B01L3/502707 , B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/04 , B01L2200/10 , B01L2200/147 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/1827 , B01L2400/0478
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。
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公开(公告)号：US20140057279A1
公开(公告)日：2014-02-27
申请号：US14070466
申请日：2013-11-01
Applicant: California Institute Of Technology
Inventor： Imran R. MALIK , Erika F. GARCIA , Xiomara Linnette MADERO , Axel SCHERER
IPC: C12Q1/68
CPC classification number: C12Q1/686 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/0816 , B01L2400/0478 , F17D3/00 , G01N1/286 , G01N21/03 , G01N21/552 , G01N21/648 , G01N35/04 , G01N2001/2866 , G01N2001/4061 , G01N2021/0325 , G01N2035/00326 , G01N2035/00465 , G01N2035/0446 , G01N2035/1048 , G01N2035/1058 , G01N2201/0221 , Y02A50/58
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. The device may have a reaction cartridge with a reaction chamber to perform techniques such as polymerase chain reaction.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。 该装置可以具有带有反应室的反应筒，以进行诸如聚合酶链式反应的技术。
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公开(公告)号：US20240201090A1
公开(公告)日：2024-06-20
申请号：US18592324
申请日：2024-02-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Xiomara Linnette MADERO , Erika F. GARCIA , Sheel Mukesh SHAH , Axel SCHERER
IPC: G01N21/64 , C12Q1/6851
CPC classification number: G01N21/6486 , C12Q1/6851
Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.
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公开(公告)号：US20150321195A1
公开(公告)日：2015-11-12
申请号：US14697507
申请日：2015-04-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER
CPC classification number: B01L7/52 , B01L3/5027 , B01L3/502715 , B01L7/5255 , B01L2200/147 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , B01L2300/1883 , C12Q1/6851 , F28D2021/0077 , F28F13/00 , F28F2013/008 , G01N21/6428 , C12Q2565/629 , C12Q2561/113 , C12Q2527/101
Abstract: Temperature control devices and methods are described. The described temperature control devices and methods comprise optical emission and detection assemblies and can be used in PCR and qPCR applications.
Abstract translation: 描述温度控制装置和方法。 所描述的温度控制装置和方法包括光发射和检测组件，并且可以用于PCR和qPCR应用中。
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公开(公告)号：US20150024481A1
公开(公告)日：2015-01-22
申请号：US14483605
申请日：2014-09-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER
IPC: B01L3/00
CPC classification number: B01L3/502784 , B01L3/502 , B01L3/502715 , B01L3/502753 , B01L3/502776 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2300/165 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0644 , C12Q1/68 , F17D3/00 , G01N35/1097 , G01N2001/4088 , Y10T137/0318 , Y10T137/8593 , Y10T137/85978
Abstract: Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.
Abstract translation: 描述用于制备样品的装置和系统。 这种装置可以包括用于控制样品运动的流体室，储存器和可移动结构。 该装置还可以包括用于执行特定操作的功能元件。
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