公开(公告)号：US20190210946A1

公开(公告)日：2019-07-11

申请号：US16242274

申请日：2019-01-08

申请人： Yantai Hemp Biotechnology Co., Ltd.

发明人： Guiwu QU ,  Ming CUI

IPC分类号： C07C37/84 ,  C07C37/82 ,  C07C37/00 ,  B01D15/26 ,  B01D15/18

摘要： A method for preparing high-purity cannabidiol is characterized in that: the leaves of cannabis and top portions of the plant which account for about one-fifth of the whole plant are used as extraction sites; a technology of combined macroporous adsorption resin chromatography and polyamide chromatography is used for purification; and a mixed solvent system is used for crystallization purification so as to ensure that the yield is improved to the maximum extent under the premise of obtaining a high-purity product. The product obtained from this method contains high-purity CBD; the method has a high yield and is a simple process, and thus easy to industrialize.

公开(公告)号：US10336690B2

公开(公告)日：2019-07-02

申请号：US14608911

申请日：2015-01-29

申请人： Honeywell International Inc.

发明人： Gregory J. Gajda ,  Mark G. Riley ,  Venkatraman Mohan ,  Sandra M. Lorenz ,  Alan P. Cohen

IPC分类号： B01D3/14 ,  C07H1/00 ,  B01D15/26 ,  B01D15/36 ,  C07H21/00 ,  C07C253/34 ,  C07C255/03

摘要： Methods for purifying an acetonitrile waste stream are provided. An exemplary method for purifying an acetonitrile waste stream includes generating an acetonitrile waste stream during oligonucleotide synthesis and fractionating the acetonitrile waste stream to produce a single overhead fraction. The method includes condensing the single overhead fraction to produce a condensed single overhead fraction and contacting the condensed single overhead fraction with an adsorbent material to produce an acetonitrile stream that comprises an amount of an impurity that is reduced relative to the acetonitrile waste stream.

公开(公告)号：US10086123B2

公开(公告)日：2018-10-02

申请号：US14646833

申请日：2013-11-05

申请人： GAMBRO LUNDIA AB

发明人： Arne Welzel ,  Markus Storr ,  Bernd Krause ,  Hermann Goehl ,  Ralf Flieg

IPC分类号： A61M1/16 ,  B01J20/28 ,  A61M1/34 ,  B01D69/14 ,  B01D15/32 ,  B01D15/36 ,  B01D63/02 ,  B01D15/26 ,  B01J47/014 ,  A61M1/26 ,  B01D71/42 ,  B01D71/56 ,  B01D71/68 ,  B01D63/04 ,  B01D61/24 ,  B01D61/30 ,  B01J20/20 ,  B01J20/26 ,  B01J20/10 ,  B01D15/38 ,  B01D69/08 ,  D01D5/24

摘要： An extracorporeal system for liver dialysis comprises a filter device having hollow fibers with integrated ion-exchange particles and hydrophobic adsorbent particles in the filtrate space. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.

公开(公告)号：US20180257002A1

公开(公告)日：2018-09-13

申请号：US15789410

申请日：2017-10-20

申请人： Cambridge Enterprise Limited

发明人： Yii Leng Chua

IPC分类号： B01D15/20 ,  C12N15/10 ,  B01D17/02 ,  B01D15/24 ,  B01D11/02 ,  B01D15/00 ,  B01D15/02 ,  B01D15/26

CPC分类号： B01D15/20 ,  B01D11/02 ,  B01D11/0219 ,  B01D15/00 ,  B01D15/02 ,  B01D15/24 ,  B01D15/245 ,  B01D15/26 ,  B01D17/02 ,  B01D17/0202 ,  C12N15/1006 ,  C12N15/101 ,  C12N15/1017

摘要： A method for obtaining a liquid from a porous solid phase is described. The method comprises forming a liquid seal at a first end of a porous solid phase to which a liquid is bound, wherein liquid of the liquid seal is immiscible with the liquid bound to the solid phase, and applying a pressure differential across the porous solid phase to cause the immiscible liquid to move through the porous solid phase towards a second end of the porous solid phase, thereby displacing the liquid bound to the porous solid phase towards the second end and releasing this liquid from the second end. Recovery of liquid from the solid phase using such methods is increased compared with corresponding methods in which no liquid seal is formed. In preferred embodiments, the liquid used to form the liquid seal is a mineral oil. The methods have particular application in nucleic acid extractions which utilise capture of nucleic acid to a solid phase. Kits and apparatus for performing the methods are also described.

公开(公告)号：US10052427B2

公开(公告)日：2018-08-21

申请号：US14646919

申请日：2013-11-05

申请人： GAMBRO LUNDIA AB

发明人： Ralf Flieg ,  Torsten Knoer ,  Wolfgang Freudemann ,  Mehmet Yildirim ,  Martin Rempfer ,  Steffen Wagner ,  Markus Storr

IPC分类号： A61M1/34 ,  B01D15/36 ,  B01D61/00 ,  B01J20/28 ,  B01D15/12 ,  B01D69/08 ,  B01D15/32 ,  B01D15/26 ,  B01D15/38 ,  B01D63/02

CPC分类号： A61M1/3475 ,  A61M1/3413 ,  A61M1/3472 ,  A61M1/3486 ,  B01D15/125 ,  B01D15/265 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01D61/00 ,  B01D63/02 ,  B01D63/021 ,  B01D69/08 ,  B01D2311/2626 ,  B01D2313/40 ,  B01D2325/20 ,  B01J20/28016 ,  Y10T29/4989

摘要： A filter apparatus, a method for the manufacture of the filter apparatus, the use of the filter apparatus in medical, chemical and/or biotechnological applications, and an apparatus for use in the manufacture of the filter apparatus. The filter apparatus has a cylindrical housing and a plurality of hollow fibers. The hollow fibers are combined to form a bundle in the housing and are embedded and held in each case at the end sides in a molding compound. The filtrate space is filled with particles of a chemically or physically active substance.

公开(公告)号：US09804133B1

公开(公告)日：2017-10-31

申请号：US14838070

申请日：2015-08-27

申请人： Mark A. Stone

发明人： Mark A. Stone

IPC分类号： G01N30/02 ,  G01N30/16 ,  B01D15/40 ,  B01D15/26

CPC分类号： G01N30/16 ,  B01D15/265 ,  B01D15/40 ,  G01N30/08 ,  G01N2030/027 ,  G01N2030/085

摘要： A method and apparatus for enabling larger injection volumes and for reducing extra column effects in chromatographic separations using focusing pre-columns placed upstream of the analytical, or preparative, column with applications in any chromatographic system where the requirement is that the focusing pre-column, placed upstream of the analytical column, allows larger injection volumes to be utilized and, by enabling efficient focusing of solutes onto the analytical column, results in a significant reduction of band broadening due to extra-column effects which act upstream of the analytical column.

公开(公告)号：US09765000B2

公开(公告)日：2017-09-19

申请号：US15004848

申请日：2016-01-22

申请人： Phytoplant Research S.L.

发明人： Xavier Nadal Roura

IPC分类号： C07C37/68 ,  A61K36/185 ,  B01D15/26 ,  C07C37/84 ,  C07C39/19 ,  C07C39/23 ,  C07C51/43 ,  C07C65/19

CPC分类号： C07C37/685 ,  A61K36/185 ,  A61K2236/00 ,  B01D15/26 ,  C07C37/84 ,  C07C39/19 ,  C07C39/23 ,  C07C51/43 ,  C07C65/19

摘要： The present specification discloses methods of purifying one or more cannabinoids from a plant material, purified cannabinoids and pharmaceutical compositions comprising one or more cannabinoids produced by the disclosed method, methods and uses for treating a disease or condition employing such purified cannabinoids and pharmaceutical compositions.

公开(公告)号：US09731221B2

公开(公告)日：2017-08-15

申请号：US14890477

申请日：2014-05-13

申请人： CIDRA CORPORATE SERVICES INC.

发明人： Paul J. Rothman ,  Mark R. Fernald ,  Francis K. Didden ,  Douglas H. Adamson

IPC分类号： B01D15/26 ,  B01D15/20 ,  B01J20/26

CPC分类号： B01D15/26 ,  B01D15/206 ,  B01J20/262

摘要： An apparatus for collecting mineral particles in a slurry or the tailings is disclosed, including a collection area or tank having one or more collection surfaces configured to contact with a mixture having water and valuable material, the valuable material having a plurality of mineral particles of interest; and a synthetic material provided at least on the one or more collection surfaces, the synthetic material having plurality of molecules with a siloxane functional group configured to attract the mineral particles of interest to the collection surfaces. The one or more collection surfaces includes a conveyor belt that is driven through the collection area or tank, through a release area or tank, back through the collection area or tank. The mixture includes a pulp slurry having ground ore with mineral particles of interest forming part thereof, including mineral particles of interest of about 500 microns or larger.

公开(公告)号：US20170192024A1

公开(公告)日：2017-07-06

申请号：US15312777

申请日：2015-05-21

申请人： Shiseido Company, Ltd

发明人： Yosuke TOJO ,  Masashi MITA ,  Wolfgang Lindner

IPC分类号： G01N33/94 ,  B01D15/12 ,  B01D15/26 ,  B01D15/16

摘要： The present invention addresses the problem of providing a novel method for the pretreatment of a biological sample containing lenalidomide enantiomer and thereby establishing a simple and accurate method for the quantitative analysis of lenalidomide enantiomer. In the present invention, the racemization and decomposition of lenalidomide enantiomer in a biological sample can be prevented by the deproteinization under acidic conditions of the biological sample containing lenalidomide enantiomer, and the lenalidomide enantiomer can be simply and accurately quantitatively analyzed by subjecting to HPLC the biological sample that has been pretreated in such a way.

公开(公告)号：US20170174534A1

公开(公告)日：2017-06-22

申请号：US14977564

申请日：2015-12-21

申请人： International Business Machines Corporation

发明人： Geraud J. Dubois ,  Young-Hye Na ,  Lianna Samuel ,  Ran Wang

IPC分类号： C02F1/28 ,  B01D15/26 ,  C07F9/44

CPC分类号： C02F1/285 ,  B01D15/265 ,  C02F1/001 ,  C02F1/288 ,  C02F2101/306 ,  C02F2101/34 ,  C02F2305/08 ,  C07F9/3813 ,  C07F9/4465

摘要： A method includes removing glyphosate from a solution by contacting the solution with a mesoporous inorganic particle having an average pore size of greater than zero and less than about 50 nm, wherein the mesoporous inorganic particle is functionalized with a positively charged moiety selected from ammonium, amine and combinations thereof.