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1.发明公开公开(公告)号：US20240269220A1
公开(公告)日：2024-08-15
申请号：US18566993
申请日：2022-03-24
发明人： Tsong-Long HWANG , Yu-Chia CHANG , Wu-Dai-Yu JIANG
IPC分类号： A61K36/898 , A61K31/05 , A61K31/085 , A61K31/09
CPC分类号： A61K36/898 , A61K31/05 , A61K31/085 , A61K31/09
摘要： Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of an extract of Bletilla formosana. The Bletilla formosana extract includes, at least, compounds of 3,3′-dihydroxy-5-methoxybibenzyl (Batatacin III), 9,10-dihydro-1-[(4-hydroxyphenyl)methyl]-4-methoxy-2,7-phenanthrenediol (Orchidble), 3′,5-dimethoxy-3-hydroxybibenzyl (BF8-4-2), 3,5-dimethoxy-3′-hydroxybibenzyl (BF8-4-3) and 3-hydroxy-5-methoxybibenzyl (BF8-4-4).
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2.发明授权公开(公告)号：US12016312B2
公开(公告)日：2024-06-25
申请号：US17293991
申请日：2019-11-12
发明人： Yan Zhang , Lai Wei , Hui Ouyang
IPC分类号： A61K31/085 , A01K67/00 , A61K31/12 , A61K31/235 , A61K31/437 , A61K31/704 , C12N1/20 , C12R1/11 , C12R1/40 , G01N33/50
CPC分类号： A01K67/00 , A61K31/085 , A61K31/12 , A61K31/235 , A61K31/437 , A61K31/704 , C12N1/20 , G01N33/5044 , A01K2207/10 , A01K2227/106 , A01K2267/03 , C12R2001/11 , C12R2001/40
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
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公开(公告)号：US20240165061A1
公开(公告)日：2024-05-23
申请号：US18430796
申请日：2024-02-02
IPC分类号： A61K31/19 , A61K31/045 , A61K31/085 , A61K31/20
CPC分类号： A61K31/19 , A61K31/045 , A61K31/085 , A61K31/20
摘要： Disclosed herein are compounds and ligands, and compositions formed therewith, that modulate insulin secretion and suppress appetite by activating ectopic olfactory receptors. Also disclosed herein are methods for using the compositions to treat endocrine diseases, such as type-2 diabetes, and disorders, such as abnormal insulin secretion.
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公开(公告)号：US11980594B2
公开(公告)日：2024-05-14
申请号：US17828983
申请日：2022-05-31
发明人： Chung-Yang Huang , Chia-Chung Hou
IPC分类号： A61K31/085 , A61K31/495 , A61P35/00
CPC分类号： A61K31/085 , A61K31/495 , A61P35/00
摘要： The present invention provides a combination and method for treating a Temozolomide (TMZ)-resistant cancer patient, which comprises a combination of TMZ and an isoform-selective HDAC8 inhibitor, such as BMX at an effective relative ratio to overcome TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the β-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition.
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公开(公告)号：US20240131097A1
公开(公告)日：2024-04-25
申请号：US18494658
申请日：2023-10-24
IPC分类号： A61K36/05 , A23L33/105 , A61K8/34 , A61K8/49 , A61K31/055 , A61K31/085 , A61K31/352 , A61P29/00
CPC分类号： A61K36/05 , A23L33/105 , A61K8/347 , A61K8/498 , A61K31/055 , A61K31/085 , A61K31/352 , A61P29/00 , A61K2236/33 , A61K2236/53
摘要： The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
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公开(公告)号：US20240016734A1
公开(公告)日：2024-01-18
申请号：US18334986
申请日：2023-06-14
IPC分类号： A61K9/00 , A61K31/137 , A61K31/05 , A61K31/201 , A61K31/085 , A61K31/36 , A61K47/02 , A61K31/222
CPC分类号： A61K9/006 , A61K31/137 , A61K31/05 , A61K31/222 , A61K31/085 , A61K31/36 , A61K47/02 , A61K31/201
摘要： Pharmaceutical compositions of epinephrine and its prodrugs are described and the compositions having enhanced active component permeation properties are described as being administered with specific residence times.
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公开(公告)号：US11786481B2
公开(公告)日：2023-10-17
申请号：US17221181
申请日：2021-04-02
申请人： BioMendics, LLC
IPC分类号： A61K31/05 , A61K31/085 , A61K31/09 , A61K31/7034 , A61K45/06 , A61K9/06 , A61K47/36 , A61K47/40 , A61Q19/08 , A61Q7/00 , A61K8/34 , A61K8/33 , A61K8/60 , A61K8/73 , A61K8/67 , A61K9/00 , A61K9/08 , A61K9/19 , A61K8/70 , A61K31/03 , A61K31/167 , A61K31/375 , A61K31/655
CPC分类号： A61K31/05 , A61K8/33 , A61K8/347 , A61K8/602 , A61K8/676 , A61K8/70 , A61K8/733 , A61K8/738 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K9/19 , A61K31/03 , A61K31/085 , A61K31/09 , A61K31/167 , A61K31/375 , A61K31/655 , A61K31/7034 , A61K45/06 , A61K47/36 , A61K47/40 , A61Q7/00 , A61Q19/08 , Y02A50/30 , A61K31/05 , A61K2300/00 , A61K31/03 , A61K2300/00 , A61K31/7034 , A61K2300/00 , A61K31/085 , A61K2300/00 , A61K31/09 , A61K2300/00 , A61K31/167 , A61K2300/00 , A61K31/655 , A61K2300/00
摘要： Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I):
wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CRa═CRb— a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with —(R3)p or —(R4)q;
R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.-
公开(公告)号：US20230301884A1
公开(公告)日：2023-09-28
申请号：US18002859
申请日：2021-06-21
申请人： RHT LIMITED
发明人： Ka Wai JIM , Rudy Chi Keung CHAN
IPC分类号： A61K8/34 , A61K8/67 , A61K8/81 , A61K8/37 , A61K8/36 , A61Q17/00 , A61K31/047 , A61K31/085 , A61K31/164 , A61K31/20 , A61K31/78 , A61P31/14
CPC分类号： A61K8/345 , A61K8/347 , A61K8/361 , A61K8/37 , A61K8/673 , A61K8/8152 , A61K31/047 , A61K31/085 , A61K31/164 , A61K31/20 , A61K31/78 , A61P31/14 , A61Q17/005 , A61K2800/30
摘要： In one aspect, provided is an aqueous antiseptic composition comprising glycerin 8.5-16%by weight; caprylyl glycol 0.45-3%by weight; and a first ingredient; wherein the first ingredient is acrylates/C10-30 about 0.01-0.1%by weight or ethoxydiglycol about 1-5% by weight. The glycerin, the caprylyl glycol and the first ingredient taken together form a first component. A sum of the first component is more than 13%by weight of the antiseptic composition. Other exemplary embodiments are also described. In certain embodiments, provided is an antiseptic composition useful for making skin or hand sanitizers that has a long-lasting, great antiseptic efficacy but at the same time having skin-moisturizing, low toxicity and low skin-irritating, hypo-allergenic properties, low inflammability, and low production cost.
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公开(公告)号：US11744787B2
公开(公告)日：2023-09-05
申请号：US16301233
申请日：2016-05-14
申请人： Symrise AG , Sven Siegel
发明人： Sven Siegel , Arnold Machinek , Benoit Join
IPC分类号： A61K8/37 , A61K31/05 , A61K31/222 , A61K8/34 , A61K9/68 , A61K31/085 , A61Q11/00 , A61K31/045
CPC分类号： A61K8/37 , A61K8/34 , A61K8/347 , A61K9/0058 , A61K31/045 , A61K31/05 , A61K31/085 , A61K31/222 , A61Q11/00 , A61K31/045 , A61K2300/00 , A61K31/05 , A61K2300/00 , A61K31/222 , A61K2300/00
摘要： The invention relates to aroma preparations that contain (a) a compound of the formula (I) in which R1 represents a linear or branched, saturated or unsaturated hydrocarbon group with 1 to 4 carbon atoms, R2 represents hydrogen or a hydroxyl group and R3 represents hydrogen, a methyl or methoxy group, or an essential oil containing one or more compounds of the formula (I) and at least one menthol compound.
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公开(公告)号：US20230038230A1
公开(公告)日：2023-02-09
申请号：US17828983
申请日：2022-05-31
发明人： Chung-Yang HUANG , Chia-Chung HOU
IPC分类号： A61K31/085 , A61P35/00 , A61K31/495
摘要： The present invention provides a combination and method for treating a Temozolomide (TMZ)-resistant cancer patient, which comprises a combination of TMZ and an isoform-selective HDAC8 inhibitor, such as BMX at an effective relative ratio to overcome TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the β-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition.
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