公开(公告)号：US12016312B2

公开(公告)日：2024-06-25

申请号：US17293991

申请日：2019-11-12

申请人： ZHUHAI QIWEI BIO-TECHNOLOGY LTD.

发明人： Yan Zhang ,  Lai Wei ,  Hui Ouyang

IPC分类号： A61K31/085 ,  A01K67/00 ,  A61K31/12 ,  A61K31/235 ,  A61K31/437 ,  A61K31/704 ,  C12N1/20 ,  C12R1/11 ,  C12R1/40 ,  G01N33/50

CPC分类号： A01K67/00 ,  A61K31/085 ,  A61K31/12 ,  A61K31/235 ,  A61K31/437 ,  A61K31/704 ,  C12N1/20 ,  G01N33/5044 ,  A01K2207/10 ,  A01K2227/106 ,  A01K2267/03 ,  C12R2001/11 ,  C12R2001/40

摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.