知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

74 条记录 (耗时 0.04 秒)

    MODERATION OF CRUSTACEAN ANDROGENIC GLAND PEPTIDE FOR MONO SEX CULTURE
    2.
    发明申请
    MODERATION OF CRUSTACEAN ANDROGENIC GLAND PEPTIDE FOR MONO SEX CULTURE 审中-公开

    公开(公告)号：US20160066549A9

    公开(公告)日：2016-03-10

    申请号：US14506690

    申请日：2014-10-06

    申请人： Siu Ming CHAN

    发明人： Siu Ming CHAN

    IPC分类号： A01K61/00

    CPC分类号： A01K61/005 ,  A01K61/59 ,  A01K61/90 ,  A01K2207/05 ,  A01K2207/10 ,  A01K2227/70 ,  A01K2267/02 ,  A61D19/027 ,  C12N15/1136 ,  C12N15/873 ,  Y02A40/824

    摘要： This invention is directed to methods for manipulating sex, reversing sex, changing sex ratio, or moderating crustacean androgenic gland peptide expression in crustaceans for producing a monosex culture. In one embodiment, the present method comprises the step of injecting a dsRNA for the gene of IAG into a male crustacean. In another embodiment, the present method comprises the step of injecting a dsRNA for the gene of IAG into a female crustacean that had acquired a spermatophore (a sperm sac) after mating with a male. In another embodiment, the present invention provides a method of producing a monosex culture of crustacean by introducing a recombinant IAG peptide into the female crustacean, thereby obtains male with altered sexual characteristics for mating with a normal female. In one embodiment, the crustacean is a shrimp or lobster.

    MODERATION OF CRUSTACEAN ANDROGENIC GLAND PEPTIDE FOR MONO SEX CULTURE
    5.
    发明申请
    MODERATION OF CRUSTACEAN ANDROGENIC GLAND PEPTIDE FOR MONO SEX CULTURE 审中-公开
    用于单性生殖培养的胃肠球蛋白肽的研究

    公开(公告)号：US20150096499A1

    公开(公告)日：2015-04-09

    申请号：US14506690

    申请日：2014-10-06

    申请人： Siu Ming CHAN

    发明人： Siu Ming CHAN

    IPC分类号： A01K61/00

    CPC分类号： C12N15/1136 ,  A01K61/59 ,  A01K61/90 ,  A01K2207/05 ,  A01K2207/10 ,  A01K2227/70 ,  A01K2267/02 ,  A61D19/027 ,  C12N15/873 ,  Y02A40/824

    摘要： This invention is directed to methods for manipulating sex, reversing sex, changing sex ratio, or moderating crustacean androgenic gland peptide expression in crustaceans for producing a monosex culture. In one embodiment, the present method comprises the step of injecting a dsRNA for the gene of IAG into a male crustacean. In another embodiment, the present method comprises the step of injecting a dsRNA for the gene of IAG into a female crustacean that had acquired a spermatophore (a sperm sac) after mating with a male. In another embodiment, the present invention provides a method of producing a monosex culture of crustacean by introducing a recombinant IAG peptide into the female crustacean, thereby obtains male with altered sexual characteristics for mating with a normal female. In one embodiment, the crustacean is a shrimp or lobster.

    摘要翻译： 本发明涉及用于操纵性别，逆转性别，改变性别比例或调节甲壳类动物中甲壳动物腺体肽表达以产生单调性培养物的方法。 在一个实施方案中，本方法包括将IAG基因的dsRNA注入雄性甲壳动物的步骤。 在另一个实施方案中，本方法包括将IAG基因的dsRNA注射到与雄性交配后获得精子细胞（精子囊）的雌性甲壳动物的步骤。 在另一个实施方案中，本发明提供了通过将重组IAG肽引入雌性甲壳动物来生产甲壳类动物单次培养物的方法，从而获得具有改变的性状特征的雄性与正常雌性交配。 在一个实施方案中，甲壳类是虾或龙虾。

    Use Of Humanized Mice To Determine Toxicity
    6.
    发明申请
    Use Of Humanized Mice To Determine Toxicity 审中-公开
    使用人源化小鼠来确定毒性

    公开(公告)号：US20150007357A1

    公开(公告)日：2015-01-01

    申请号：US14362774

    申请日：2012-12-05

    申请人： Massachusetts Institute Of Technology

    发明人： Salim Bouguermouh ,  Maroun Khoury ,  Qingfeng Chen ,  Jianzhu Chen

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0008 ,  A01K67/0271 ,  A01K2207/10 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/03 ,  G01N2333/715

    摘要： The invention is directed to a method of determining whether an agent causes immune toxicity in a human comprising administering the agent to a non-human mammal that has been engrafted with human hematopoietic stem cells (HSCs) and administered one or more human cytokines; and determining whether the agent causes immune toxicity in the non-human mammal. If the agent causes immune toxicity in the non-human mammal then the agent causes toxicity in a human. The invention is also directed to a method of determining whether administration of an agent causes cytokine release syndrome in an individual in need thereof comprising administering the agent to a non-human mammal that has been engrafted with HSCs and administered one or more human cytokines; and determining whether the agent causes cytokine release syndrome in the non-human mammal. If the agent causes cytokine release syndrome in the non-human mammal then the agent will cause cytokine release syndrome in the human.

    摘要翻译： 本发明涉及一种确定试剂是否在人体中引起免疫毒性的方法，其包括向已经用人造血干细胞（HSCs）移植的非人哺乳动物施用该试剂并施用一种或多种人类细胞因子; 以及确定该试剂是否在非人哺乳动物中引起免疫毒性。 如果该试剂在非人哺乳动物中引起免疫毒性，则该试剂在人体中引起毒性。 本发明还涉及一种确定在有需要的个体中是否施用药剂引起细胞因子释放综合征的方法，其包括将所述药物施用于已经被HSCs移植并且施用一种或多种人细胞因子的非人哺乳动物; 以及确定该药物是否在非人哺乳动物中引起细胞因子释放综合征。 如果该试剂在非人哺乳动物中引起细胞因子释放综合征，则该试剂将在人体中引起细胞因子释放综合征。

    TEST SYSTEMS AND METHODS FOR IDENTIFYING AND CHARACTERISING LIPID LOWERING DRUGS
    7.
    发明申请
    TEST SYSTEMS AND METHODS FOR IDENTIFYING AND CHARACTERISING LIPID LOWERING DRUGS 审中-公开
    用于鉴别和表征脂肪降低药物的测试系统和方法

    公开(公告)号：US20140065649A1

    公开(公告)日：2014-03-06

    申请号：US14114523

    申请日：2012-04-30

    申请人： Hans-Ludwig Schaefer ,  Eugen Falk ,  Uwe Schwahn

    发明人： Hans-Ludwig Schaefer ,  Eugen Falk ,  Uwe Schwahn

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0008 ,  A01K67/0276 ,  A01K2207/10 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0362 ,  A01K2267/0393 ,  G01N33/92 ,  G01N2800/32

    摘要： The present invention relates to methods for the identification and characterization of therapeutic candidates for use in the treatment of a disease or condition associated with elevated LDL-C levels involving a rodent, methods for the testing of the efficacy of an antibody specifically binding to proprotein convertase subtilisin/kexin type 9 (PCSK9) involving a rodent, as well as a rodent and its use in the identification or profiling of compounds for modulation of a disease or condition associated with elevated LDL-C levels.

    摘要翻译： 本发明涉及用于鉴定和表征用于治疗与涉及啮齿动物的升高的LDL-C水平相关的疾病或病症的治疗候选物的方法，用于测试特异性结合前蛋白转化酶的抗体的功效的方法 涉及啮齿动物的枯草杆菌蛋白酶/ kexin 9型（PCSK9）以及啮齿动物，以及其用于鉴定或分析化合物以调节与升高的LDL-C水平相关的疾病或病症的用途。

    Mouse model of retinal degeneration
    8.
    发明授权
    Mouse model of retinal degeneration 有权
    视网膜退化的小鼠模型

    公开(公告)号：US08664470B2

    公开(公告)日：2014-03-04

    申请号：US12256274

    申请日：2008-10-22

    申请人： Victor L. Perez ,  Joe G. Hollyfield ,  Robert G. Salomon

    发明人： Victor L. Perez ,  Joe G. Hollyfield ,  Robert G. Salomon

    IPC分类号： A61K39/395

    CPC分类号： A01K67/027 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008

    摘要： The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein.

    摘要翻译： 本发明涉及一种生产具有视网膜变性和/或年龄相关性黄斑变性的一种或多种病理特征的非人哺乳动物的方法。 特别地，本发明提供了一种生产具有年龄相关性黄斑变性（AMD）的非人哺乳动物的方法。 本发明还涉及通过本文所述方法生产的非人动物。 识别用于抑制视网膜退化和/或AMD的一种或多种病理特征的药剂的方法也包括在本发明中。 还提供了在有需要的个体中治疗AMD的方法，其包括向个体施用本文鉴定的药剂。

    ANIMAL MODEL FOR HIV INDUCED DISEASE
    9.
    发明申请
    ANIMAL MODEL FOR HIV INDUCED DISEASE 审中-公开
    艾滋病毒感染性疾病动物模型

    公开(公告)号：US20100275278A1

    公开(公告)日：2010-10-28

    申请号：US12794102

    申请日：2010-06-04

    申请人： Nelson M. Karp

    发明人： Nelson M. Karp

    IPC分类号： A01K67/00 ,  C12N7/00

    CPC分类号： A01K67/027 ,  A01K67/0278 ,  A01K2207/10 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0337 ,  C07K14/005 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16322

    摘要： HIV does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing, treating or curing disease caused by this virus. The present invention provides compositions and a method for producing an animal model for HIV induced disease. The present invention is an animal adapted to simulate a human-like immune response to HIV, which is accomplished by activation and inactivation of complement of proteins within the animal. Accordingly, the present invention stages certain human proteins within an animal by way of its gut associated lymphoid tissue followed by infection of live HIV.

    摘要翻译： 艾滋病毒在任何非人类物种中都不会引起疾病。 因此，没有动物模型系统来评估旨在预防，治疗或治愈由该病毒引起的疾病的策略的功效。 本发明提供了用于产生HIV诱导的疾病的动物模型的组合物和方法。 本发明是适用于模拟人类样免疫应答的动物，其通过激活和灭活动物内的蛋白质的补体来实现。 因此，本发明通过其肠道相关的淋巴组织，然后感染活的HIV来分化动物内的某些人类蛋白质。