公开(公告)号：US12053498B2

公开(公告)日：2024-08-06

申请号：US17899752

申请日：2022-08-31

申请人： BRANDEIS UNIVERSITY

发明人： Kenneth C. Hayes ,  Daniel Perlman

IPC分类号： A61K36/23 ,  A23L33/22 ,  A61P3/00 ,  A61P3/10

CPC分类号： A61K36/23 ,  A23L33/22 ,  A61P3/00 ,  A61P3/10 ,  A61K2236/00

摘要： Methods of improving mammalian carbohydrate metabolism and treating, preventing, or halting the progression of type 2 diabetes mellitus involve the consumption of a nutritional composition containing fruit or vegetable pomace. The pomace is produced from native plant tissue and contains a mixture of soluble and insoluble fiber. Periodic consumption of the composition normalizes blood glucose concentration and controls body weight.

公开(公告)号：US20230384261A1

公开(公告)日：2023-11-30

申请号：US18121505

申请日：2023-03-14

申请人： University of Rhode Island Board of Trustees ,  Brandeis University

发明人： Jason R Dwyer ,  James Hagan ,  Grace G.D. Han ,  Alejandra Gonzalez

IPC分类号： G01N27/447 ,  G01N33/487 ,  B82Y15/00

CPC分类号： G01N27/44791 ,  G01N33/48721 ,  B82Y15/00

摘要： Disclosed herein is the fabrication of a photo-regulated nanopore by covalently linking a photoswitch to the interior of a silicon-based membrane and related methods of translocating an analyte and distinguishing molecule types through such a nanopore.

公开(公告)号：US11819849B2

公开(公告)日：2023-11-21

申请号：US16834505

申请日：2020-03-30

申请人： Brandeis University

发明人： Seth Fraden ,  Galder Cristobal-Azkarate

IPC分类号： G01N1/38 ,  B01L3/00 ,  C30B7/00 ,  C30B29/58 ,  B01L3/06 ,  B01L7/00

CPC分类号： B01L3/502784 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502746 ,  C30B7/00 ,  C30B29/58 ,  G01N1/38 ,  B01L3/06 ,  B01L3/5027 ,  B01L7/54 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0655 ,  G01N2001/386 ,  Y10T137/0318 ,  Y10T436/2575

摘要： Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. In some embodiments, positioning of the droplets can take place in the order in which they are introduced into the microfluidic network (e.g., sequentially) without significant physical contact between the droplets. Because of the little or no contact between the droplets, there may be little or no coalescence between the droplets. Accordingly, in some such embodiments, surfactants are not required in either the fluid sample or the carrier fluid to prevent coalescence of the droplets. Structures and methods described herein also enable droplets to be removed sequentially from the predetermined regions.

公开(公告)号：US20230354790A1

公开(公告)日：2023-11-09

申请号：US18246250

申请日：2021-09-28

申请人： Brandeis University

发明人： Paul Allen Garrity ,  Willem Jeffrey Laursen

IPC分类号： A01K67/033 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90 ,  C07K14/435

CPC分类号： A01K67/0339 ,  C12N9/22 ,  C12N15/111 ,  C12N15/902 ,  C07K14/43563 ,  C12N2310/20 ,  C12N2800/80 ,  A01K2227/706 ,  A01K2217/072 ,  A01K2267/02

摘要： A method of making sterile diploid organisms includes mating a first population and a second population of single knock-in diploid organisms, wherein the first population of single knock-in diploid organisms are heterozygous organisms expressing a first marker inserted into a gene required for fertility, wherein the second population of single knock-in diploid organisms are heterozygous organisms expressing a second marker inserted into the gene required for fertility, wherein introduction of the first/second marker disrupts expression of the required fertility gene creating a first/second mutant allele of the gene required for fertility, and wherein the first and second markers are distinct; sorting offspring produced from the mating based on their expression of the first and/or second markers; and isolating the sterile diploid organisms, wherein the sterile diploid organisms are heteroallelic diploid organisms expressing the first marker in the first mutant allele and the second marker in the mutant second allele.

公开(公告)号：US11732256B2

公开(公告)日：2023-08-22

申请号：US16740750

申请日：2020-01-13

申请人： Brandeis University

发明人： Isaac J. Krauss ,  Satoru Horiya

IPC分类号： A61K39/00 ,  C12N15/10 ,  G01N33/68 ,  C07K19/00 ,  A61K39/21 ,  C07K16/10

CPC分类号： C12N15/1058 ,  A61K39/21 ,  C07K16/1063 ,  C07K19/00 ,  C12N15/1062 ,  G01N33/6845 ,  A61K2039/575 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/91 ,  C12N2740/16122 ,  C12N2740/16134 ,  G01N2405/00

摘要： The invention relates to a glycopolypeptide that includes one or more modified amino acid residues having a sidechain comprising a monosaccharide or an oligosaccharide, wherein the glycopolypeptide binds specifically to a carbohydrate-binding monoclonal antibody with an affinity of less than 100 nM. Immunogenic conjugates that include the glycopolypeptide, and pharmaceutical compositions that include the glycopolypeptide or the immunogenic conjugate are also disclosed. Various method of using the glycopolypeptides, immunogenic conjugates, and pharmaceutical compositions are disclosed, including inducing an immune response, inhibiting viral or bacterial infection, treating a cancerous condition, and detecting a neutralizing antibody.

公开(公告)号：US11618024B2

公开(公告)日：2023-04-04

申请号：US17184202

申请日：2021-02-24

申请人： President and Fellows of Harvard College ,  Brandeis University

发明人： Seth Fraden ,  Hakim Boukellal ,  Yanwei Jia ,  Seila Selimovic ,  Amy Rowat ,  Jeremy Agresti ,  David A. Weitz

IPC分类号： G01N1/28 ,  G01N15/00 ,  B01L3/00 ,  G01N15/02 ,  G01N15/14 ,  F17D1/12

摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.

公开(公告)号：US20230053197A1

公开(公告)日：2023-02-16

申请号：US17797204

申请日：2021-02-03

申请人： BRANDEIS UNIVERSITY ,  IMPERIAL COLLEGE INNOVATIONS LIMITED ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Ggoch Ddeul HAN ,  Mihael A. GERKMAN ,  Rosina GIBSON ,  Matthew J. FUCHTER ,  Jeffrey C. GROSSMAN

IPC分类号： C07D231/38 ,  C09K5/06 ,  F28D20/02

摘要： The present invention relates to a compound of Formula (I): whereinR1, R2, m, n, p, Q, X, Y, W, and “A” are as described herein. The present invention also relates to a process for preparation of a compound of Formula (I). Also disclosed is a thermal-storage device comprising one or more compounds of Formula (I) and a method of storing energy.

公开(公告)号：US11540934B2

公开(公告)日：2023-01-03

申请号：US16608092

申请日：2018-04-27

申请人： BRANDEIS UNIVERSITY

发明人： Ingrid Marko

IPC分类号： A61F5/00 ,  A61F5/02

摘要： An adjustable back brace configured to aid in the correction of spinal curvature during a treatment period of a patient is provided. In some aspects, the adjustable back brace comprises a rod, an inferior segment, and a superior segment. The inferior segment is configured to stabilize a pelvic region of the patient. The superior segment is configured to apply pressure to one of a first lateral side and a second lateral side of the patient, proximate a thoracic region of the patient to provide a corrective force on the spinal curvature of the patient. The superior segment is also selectively adjustable to be selectively moved and fixedly positioned in a plurality of positions along at least one of the lateral direction or the vertical direction, wherein the plurality of positions are designed for periodic adjustment of the corrective force on the spinal curvature during the treatment period.

公开(公告)号：US20220228035A1

公开(公告)日：2022-07-21

申请号：US17608594

申请日：2020-05-04

申请人： BRANDEIS UNIVERSITY

发明人： Grace G.D. HAN ,  Mihael A. GERKMAN

IPC分类号： C09J7/38 ,  C09J7/40 ,  C09J139/00

摘要： The invention relates to a device that includes a substrate and a thin film of a photo-switchable adhesive layer applied to at least one surface of the substrate. A method of releasably supporting a product that includes adhering a product onto the thin film of the device and exposing the thin film to light sufficient to cause a change in the adhesive strength of the thin film. A method of making the device is also disclosed.

公开(公告)号：US11345912B2

公开(公告)日：2022-05-31

申请号：US16711964

申请日：2019-12-12

申请人： Brandeis University ,  The General Hospital Corporation

发明人： Isaac J. Krauss ,  Satoru Horiya ,  Yollete V. Guillen Schlippe

IPC分类号： C12N15/10 ,  G01N33/68 ,  C07K19/00 ,  A61K39/21 ,  C07K16/10 ,  A61K39/00

摘要： The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combining the pool with a target protein to form a mixture; incubating the mixture for a period of time sufficient to allow any target protein to bind to one or more of the glycopolypeptides, thereby forming glycopolypeptide-target protein complexes; and isolating from the mixture the glycopolypeptide-target protein complexes, thereby identifying a plurality of selected glycopolypeptides.