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公开(公告)号：US20240336928A1
公开(公告)日：2024-10-10
申请号：US18627252
申请日：2024-04-04
CPC分类号： C12N15/78 , C07K14/21 , C12N1/205 , C12N9/52 , C12N15/52 , C12N2510/00 , C12R2001/40
摘要： Disclosed herein are five genes that were identified and engineered into Pseudomonas putida KT2440 and P. putida CJ781 to improve tolerance to sodium salt (Na+).
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2.发明授权公开(公告)号：US12016312B2
公开(公告)日：2024-06-25
申请号：US17293991
申请日：2019-11-12
发明人： Yan Zhang , Lai Wei , Hui Ouyang
IPC分类号： A61K31/085 , A01K67/00 , A61K31/12 , A61K31/235 , A61K31/437 , A61K31/704 , C12N1/20 , C12R1/11 , C12R1/40 , G01N33/50
CPC分类号： A01K67/00 , A61K31/085 , A61K31/12 , A61K31/235 , A61K31/437 , A61K31/704 , C12N1/20 , G01N33/5044 , A01K2207/10 , A01K2227/106 , A01K2267/03 , C12R2001/11 , C12R2001/40
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
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公开(公告)号：US20240327877A1
公开(公告)日：2024-10-03
申请号：US18625942
申请日：2024-04-03
申请人： Alliance for Sustainable Energy, LLC , Massachusetts Institute of Technology , Wisconsin Alumni Research Foundation , UT-Battelle, LLC
发明人： Gregg Tyler BECKHAM , Chad Thomas PALUMBO , Allison Jean ZIMONT WERNER , Kevin P. SULLIVAN , Yuriy ROMÁN , Shannon Scot STAHL , Adam Michael GUSS , Jay D. HUENEMANN , Thomas David MAND , Kathryn MAINS , Austin Lee CARROLL
CPC分类号： C12P7/18 , C12N1/205 , C12P2201/00 , C12R2001/40
摘要： Described herein is a chemical process for the conversion of lignocellulosic biomass into muconic acid which is useful for the generation of plastics and polymers. The described methods utilize catalytic chemical reactions and biological processes to facilitate the conversion, while increasing yields and reducing energy requirements.
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公开(公告)号：US20230323410A1
公开(公告)日：2023-10-12
申请号：US18002747
申请日：2021-07-02
CPC分类号： C12P7/46 , C12N9/0071 , C12N9/001 , C12N9/0069 , C12N15/78 , C12Y103/01025 , C12Y113/11001 , C12Y114/1201 , C12R2001/40
摘要： Herein are disclosed bacterial cells useful for production of 2-fluoro-cis,cis-muconate and derivatives thereof. The disclosure also provides methods and nucleic acid constructs therefor.
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公开(公告)号：US20240327329A1
公开(公告)日：2024-10-03
申请号：US18626102
申请日：2024-04-03
发明人： Gregg Tyler BECKHAM , Nina X. GU , Chad Thomas PALUMBO , Kevin P. SULLIVAN , Shannon Scot STAHL
CPC分类号： C07C67/39 , C12N1/205 , C12P7/18 , C12R2001/40
摘要： Disclosed herein are methods and compositions of matter showing that catalytic autoxidation can be used to generate aromatic monomers from C—C linked dimers and oligomers derived from lignin. This is demonstrated by acetylating phenol-rich RCF oil and then conducting aerobic oxidation of the oligomeric fraction of poplar RCF oil with a Co/Mn/Br catalyst mixture in acetic acid. This reaction yields a collection of oxygenated aromatic monomers that represent a 17% increase in monomer yield compared to the RCF process alone.
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6.发明公开公开(公告)号：US20240298616A1
公开(公告)日：2024-09-12
申请号：US18656010
申请日：2024-05-06
发明人： Yan ZHANG , Lai WEI , Hui OUYANG
IPC分类号： A01K67/00 , A61K31/085 , A61K31/12 , A61K31/235 , A61K31/437 , A61K31/704 , C12N1/20 , C12R1/11 , C12R1/40 , G01N33/50
CPC分类号： A01K67/00 , A61K31/085 , A61K31/12 , A61K31/235 , A61K31/437 , A61K31/704 , C12N1/20 , G01N33/5044 , A01K2207/10 , A01K2227/106 , A01K2267/03 , C12R2001/11 , C12R2001/40
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
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公开(公告)号：US20240263207A1
公开(公告)日：2024-08-08
申请号：US17286855
申请日：2019-10-23
CPC分类号： C12P19/40 , C12N1/205 , C12N9/1077 , C12N9/1085 , C12N9/2497 , C12N15/78 , C12R2001/40 , C12Y204/02028 , C12Y205/01063 , C12Y302/02009
摘要： The present invention relates to a cell capable of producing a fluorinated, a chlorinated or a brominated compound, methods for producing fluorinated, chlorinated or brominated compounds in a cell and expression systems therefor.
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8.发明公开公开(公告)号：US20240060096A1
公开(公告)日：2024-02-22
申请号：US17556966
申请日：2021-12-20
CPC分类号： C12P7/22 , C12N9/0006 , C12N9/88 , C12N9/1029 , C12N1/205 , C12R2001/40
摘要： A method of producing 1,8-dihydroxy naphthalene (DHN) is provided. The method includes culturing cells under suitable culture conditions for the production of DHN. The cells include a nucleic acid encoding a polyketide synthase polypeptide and one or more nucleic acids encoding one or more protein enzymes used in the DHN melanin pathway. DHN melanin pathway genes may be expressed in the cells, which may recombinant E. coli cells. The cells may include inhibitors to stop the conversion of DHN into melanin within the cells. The cells may include glucose as a cell nutrient. The glucose may be derived from biomass. DHN may be produced, harvested and the harvested DHN may be catalyzed into a cyclic hydrocarbon.
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公开(公告)号：US11807873B2
公开(公告)日：2023-11-07
申请号：US17504901
申请日：2021-10-19
发明人： Christopher W. Johnson , Allison Jean Zimont Werner , Gregg Tyler Beckham , Sandra Fabienne Notonier
CPC分类号： C12N9/0071 , C12N9/0069 , C12N9/0073 , C12P7/44 , C12N1/205 , C12R2001/39 , C12R2001/40 , C12Y114/13082
摘要： The present disclosure relates to a genetically modified microbial cell that includes a first genetic modification resulting in the expression of an exogenous vanillate demethylase, such that the microbial cell is capable of metabolizing an S-lignin decomposition product and producing 2-pyrone-4,6-dicarboxylate (PDC).
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