摘要:
Systems and methods for producing organisms that lack one or more undesired traits are disclosed. In some implementations, a method includes obtaining (or producing) a first parent organism of a donor family of breeding stock and obtaining (or producing) a second parent organism from a receptor family of breeding stock. Some implementations of the method include mating the first parent organism with the second parent organism to produce a progeny organism. In some cases, a combination of genetic material from the first parent organism and the second parent organism in the progeny organism prevents development of the undesired trait (or of an organism having the undesired trait). Other implementations are also described.
摘要:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.
摘要:
A selective breeding method of a new strain of Crassostrea gigas with orange left and right shells includes: selecting individuals of C. gigas with purple left shell and black mantle as the male broodstocks and individuals of C. gigas with black left shell and black mantle as the female broodstocks from cultured populations to generate a F1 family by applying single-pair mating strategy; selecting individuals with black purple left and right shells and black mantle from the F1 family as broodstocks to generate F2 families through family selection; selecting individuals with black purple left and right shells and black mantle from the F2 families as broodstocks to generate F3 families through family selection; and selecting individuals with orange left and right shells from the F3 families as broodstocks to propagate to generate a new strain of C. gigas with the stably inherited trait of orange left and right shells.
摘要:
A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron centre selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.
摘要:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.
摘要:
A floorless shelter has a closable door and a rear ventilation window that offers shelter in inclement weather for an owner/trainer and canine during housebreaking, as well as for use on a continuing basis. The floorless shelter also provides a specific area, recommended for housebreaking, which reduces distractions because it is enclosed. After repeatedly being taken to the structure, especially in inclement weather, the canine becomes conditioned to use the specific area and appreciate the protection from the elements that the structure provides. The floorless shelter makes the housebreaking and continued use both convenient and successful.
摘要:
An apparatus for testing and researching aquatic species is provided. The apparatus includes a housing rack for housing a tank. The apparatus further includes one or more dividers for dividing the at least one tank into one or more compartments. The apparatus further includes a collection channel and a downspout in each compartment for draining of water from each compartment. The apparatus further includes one or more lids for covering the one or more compartments.
摘要:
The invention can produce an infected nail of an animal and an infected animal model in which the nail plate and nail bed of the nail are sufficiently infected with a superficial fungus which were difficult to be produced in the past, and provides an evaluation method useful for development of a therapeutic agent for intractable infectious diseases such as tinea unguium using the nail and the infected animal model. For producing the infected nail of an animal and the infected animal model infected with a superficial fungus, an immunosuppressive component is administered to an animal in advance to decrease immunocompetence, and then, a superficial fungus is inoculated into the animal, whereby the infected nail of an animal and the infected animal model reflecting clinical manifestation in which the nail plate and nail bed of the nail are sufficiently infected with the superficial fungus can be produced with good reproducibility in a short period of time.
摘要:
The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation colony are produced and used to re-establish the foundation colony at appropriate intervals.