- 专利标题： COMPOSITION AND METHOD FOR TREATING A DRUG-RESISTANT CANCER
-
申请号： US17828983申请日： 2022-05-31
-
公开(公告)号： US20230038230A1公开(公告)日： 2023-02-09
- 发明人: Chung-Yang HUANG , Chia-Chung HOU
- 申请人： NatureWise Biotech & Medicals Corporation
- 申请人地址： TW Taipei City
- 专利权人： NatureWise Biotech & Medicals Corporation
- 当前专利权人： NatureWise Biotech & Medicals Corporation
- 当前专利权人地址： TW Taipei City
- 主分类号： A61K31/085
- IPC分类号： A61K31/085 ; A61P35/00 ; A61K31/495
摘要：
The present invention provides a combination and method for treating a Temozolomide (TMZ)-resistant cancer patient, which comprises a combination of TMZ and an isoform-selective HDAC8 inhibitor, such as BMX at an effective relative ratio to overcome TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the β-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition.
公开/授权文献
- US11980594B2 Composition and method for treating a drug-resistant cancer 公开/授权日：2024-05-14
信息查询
