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公开(公告)号：US20240002396A1
公开(公告)日：2024-01-04
申请号：US18030747
申请日：2021-10-06
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.
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公开(公告)号：US11130764B2
公开(公告)日：2021-09-28
申请号：US16486814
申请日：2018-02-01
IPC分类号： A61K31/439 , C07D487/18 , C07D401/04 , C07D401/14 , C07D471/14 , C07D471/16 , C07D471/20 , C07D471/22 , C07D487/04 , C07D491/22
摘要： The present disclosure provides compounds of any one of Formulae (I′), (I), (IA), (II′), (II), (IIA), (IIIA), (III″), (III′), (III), (IIIA), (IV), (V′), (V), (VI), (VII), (VIII′), (VIII), (IX′), (IX), and (X). The compounds described herein may be useful in treating and/or preventing a broad range of diseases (e.g., proliferative disease (e.g., cancers (e.g., non-small cell lung cancer, or glioma), inflammatory diseases, autoimmune diseases), CNS disorder (e.g., drug addiction), metabolic disorder (e.g., diabetes), or infectious disease (e.g., bacterial infection or parasitic infection (e.g., malaria))). Also provided in the present disclosure are pharmaceutical compositions, methods of synthesis of a compound described herein, kits, methods, and uses including or using a compound described herein.
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公开(公告)号：US20200317732A1
公开(公告)日：2020-10-08
申请号：US16857934
申请日：2020-04-24
发明人： Hendrik Luesch , Qi-Yin Chen
IPC分类号： C07K5/12 , A61K31/424 , A61K31/429 , C07D207/16 , A61K45/06 , C07K5/107 , A61K38/12
摘要： The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
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公开(公告)号：US20190256490A1
公开(公告)日：2019-08-22
申请号：US16097167
申请日：2017-04-28
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/14 , C07D498/16 , C07D487/04 , A61P35/00 , A61P29/00
摘要： The present disclosure provides compounds of Formulae (I-A), (II′), (III-A), (IV′), and (V-A), wherein the compounds are derived from or based on yohimbine. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, cancers, inflammatory diseases, autoimmune diseases, and infectious diseases) in a subject in need thereof. The present disclosure provides methods of preparing compounds of Formulae (I-A), (II′), (III-A), (IV′), and (V-A). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
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5.发明申请MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT 审中-公开大理石治疗剂，制造方法和治疗方法公开(公告)号：US20170057996A1
公开(公告)日：2017-03-02
申请号：US15120356
申请日：2015-02-20
发明人： Hendrik Luesch , Qi-Yin Chen
CPC分类号： C07K5/126 , A61K31/424 , A61K31/429 , A61K38/12 , A61K45/06 , C07D207/16 , C07K5/1016 , A61K2300/00
摘要： The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
摘要翻译： 本发明描述了具有治疗活性的大环化合物，以及治疗诸如自身免疫性疾病，炎症和癌症，肿瘤和细胞增殖相关病症等疾病的机制和方法。
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公开(公告)号：US20240226211A9
公开(公告)日：2024-07-11
申请号：US18494658
申请日：2023-10-25
IPC分类号： A61K36/05 , A23L33/105 , A61K8/34 , A61K8/49 , A61K31/055 , A61K31/085 , A61K31/352 , A61P29/00
CPC分类号： A61K36/05 , A23L33/105 , A61K8/347 , A61K8/498 , A61K31/055 , A61K31/085 , A61K31/352 , A61P29/00 , A61K2236/33 , A61K2236/53
摘要： The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
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公开(公告)号：US11242331B2
公开(公告)日：2022-02-08
申请号：US16097167
申请日：2017-04-28
IPC分类号： C07D401/04 , A61P35/00 , C07D401/14 , C07D487/04 , A61K31/4745 , A61P29/00 , C07D405/14 , C07D409/14 , C07D471/14 , C07D498/16 , C07D471/16
摘要： The present disclosure provides compounds of Formulae (I-A), (II′), (III-A), (IV′), and (V-A), wherein the compounds are derived from or based on yohimbine. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, cancers, inflammatory diseases, autoimmune diseases, and infectious diseases) in a subject in need thereof. The present disclosure provides methods of preparing compounds of Formulae (I-A), (II′), (III-A), (IV′), and (V-A). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
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公开(公告)号：US20210161980A1
公开(公告)日：2021-06-03
申请号：US16770558
申请日：2018-12-06
IPC分类号： A61K36/05 , A23L33/105 , A61K31/055 , A61K31/352 , A61K31/085 , A61K8/49 , A61K8/34 , A61P29/00
摘要： The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
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公开(公告)号：US11718645B2
公开(公告)日：2023-08-08
申请号：US16857934
申请日：2020-04-24
发明人： Hendrik Luesch , Qi-Yin Chen
IPC分类号： C07K5/12 , A61K31/424 , A61K31/429 , C07D207/16 , A61K45/06 , C07K5/107 , A61K38/12
CPC分类号： C07K5/126 , A61K31/424 , A61K31/429 , A61K38/12 , A61K45/06 , C07D207/16 , C07K5/1016 , A61K31/424 , A61K2300/00 , A61K31/429 , A61K2300/00
摘要： The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
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公开(公告)号：US20240131097A1
公开(公告)日：2024-04-25
申请号：US18494658
申请日：2023-10-24
IPC分类号： A61K36/05 , A23L33/105 , A61K8/34 , A61K8/49 , A61K31/055 , A61K31/085 , A61K31/352 , A61P29/00
CPC分类号： A61K36/05 , A23L33/105 , A61K8/347 , A61K8/498 , A61K31/055 , A61K31/085 , A61K31/352 , A61P29/00 , A61K2236/33 , A61K2236/53
摘要： The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
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