公开(公告)号：US20180265591A1

公开(公告)日：2018-09-20

申请号：US15866759

申请日：2018-01-10

申请人： Celera Corporation

发明人： Steve RUBEN ,  Tao HE ,  Candy LEE ,  Karen VAN ORDEN ,  Paul MOORE

IPC分类号： C07K16/30 ,  C12Q1/6886 ,  C07K16/18 ,  C12N15/113 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K16/3076 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70546 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/2839 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/303 ,  C07K16/40 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N9/18 ,  C12N9/6424 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y301/01 ,  C12Y304/21 ,  C12Y304/21109 ,  G01N33/57488 ,  G01N33/57492

摘要： Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

公开(公告)号：US09988621B2

公开(公告)日：2018-06-05

申请号：US14373029

申请日：2012-02-15

申请人： Anja Patten ,  Christof Nolde ,  Petra Vogt

发明人： Anja Patten ,  Christof Nolde ,  Petra Vogt

IPC分类号： C12N9/99 ,  C11D3/386 ,  C11D3/39 ,  C11D11/00 ,  B01D65/02

CPC分类号： C12N9/99 ,  B01D65/02 ,  B01D2321/166 ,  C11D3/386 ,  C11D3/3945 ,  C11D11/0017 ,  C11D11/0023 ,  C12Y301/01

摘要： The present invention relates to a method for the inactivation of enzymes with a composition comprising a sulfonated peroxycarboxylic acid according to formula (I) wherein: R1 is hydrogen, or a substituted or unsubstituted Cm alkyl group; R2 is a substituted or unsubstituted Cn alkyl group; X is a hydrogen atom, a cationic group, or an ester forming moiety; Y is a hydrogen atom, a cationic group, or an ester forming moiety; n is 1 to 10; m is 1 to 10; and n+m is less than or equal to 18, wherein the composition is contacted with the enzyme.

公开(公告)号：US20180080032A1

公开(公告)日：2018-03-22

申请号：US15830765

申请日：2017-12-04

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Kechun ZHANG ,  Mingyong XIONG

IPC分类号： C12N15/52 ,  C12N9/02 ,  C12N9/88 ,  C12N9/18 ,  C12N9/04 ,  C12P7/18

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/18 ,  C12N9/88 ,  C12P7/18 ,  C12Y101/01 ,  C12Y101/01001 ,  C12Y102/01026 ,  C12Y301/01 ,  C12Y301/01068 ,  C12Y401/01007 ,  C12Y402/00 ,  C12Y402/01082

摘要： This disclosure describes a recombinant microbial cells and methods of making and using such recombinant microbial cells. Generally, the recombinant cells may be modified to exhibit increased biosynthesis of a TCA derivative compared to a wild-type control. In some embodiments, the TCA derivative can include 1,4-butanediol. In various embodiments, the microbial cell is a fungal cell or a bacterial cell. In some embodiments, the increased biosynthesis of the TCA derivative can include an increase in xylose dehydrogenase activity, xylonolactonase activity, xylonate dehydratase activity, or 2-keto-3-deoxyaldonic acid dehydratase activity.

公开(公告)号：US20170362565A1

公开(公告)日：2017-12-21

申请号：US15585078

申请日：2017-05-02

申请人： Genomatica, Inc.

发明人： Priti PHARKYA ,  Anthony P. BURGARD ,  Stephen J. VAN DIEN ,  Robin E. OSTERHOUT ,  Mark J. BURK ,  John D. TRAWICK ,  Michael P. KUCHINSKAS ,  Brian STEER

IPC分类号： C12N1/20 ,  C12P7/18 ,  C12N15/63 ,  C12N15/52 ,  C12N9/18 ,  C07C31/20 ,  C08G63/181 ,  C08G63/16 ,  C08G63/06 ,  C08G18/32 ,  C08G18/28 ,  C07C59/01 ,  C12P7/42 ,  C08G69/02

CPC分类号： C12N1/20 ,  C07C31/207 ,  C07C59/01 ,  C08G18/284 ,  C08G18/3206 ,  C08G63/06 ,  C08G63/16 ,  C08G63/181 ,  C08G69/02 ,  C12N9/18 ,  C12N15/52 ,  C12N15/63 ,  C12P7/18 ,  C12P7/42 ,  C12Y301/01 ,  Y02P20/52

摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.

公开(公告)号：US09775783B2

公开(公告)日：2017-10-03

申请号：US15587513

申请日：2017-05-05

申请人： Alcresta Therapeutics, Inc.

发明人： Alexey L. Margolin ,  Robert Gallotto ,  Bhami Shenoy

IPC分类号： A01N1/00 ,  C12M3/00 ,  A61J15/00 ,  A61K9/00 ,  A23D7/01 ,  A23D9/013 ,  B65D85/72 ,  B65D81/32 ,  B65D41/02 ,  B65D1/02 ,  A61K38/46 ,  A61K31/202 ,  A23K20/158 ,  A23L29/00 ,  A23L33/00 ,  A23L33/115 ,  A23L33/12 ,  A23K50/30

CPC分类号： A61J15/0092 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23K50/30 ,  A23L29/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61J15/0003 ,  A61J15/0026 ,  A61K9/0029 ,  A61K31/202 ,  A61K38/465 ,  B65D1/02 ,  B65D41/02 ,  B65D81/32 ,  B65D85/72 ,  C12Y301/00 ,  C12Y301/01

摘要： Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.

公开(公告)号：US20170240875A1

公开(公告)日：2017-08-24

申请号：US15506881

申请日：2015-08-27

申请人： Renescience A/S

发明人： Hanne Risbjerg Soerensen ,  Lisa Rosgaard ,  Henrik B. Nielsen ,  Lone Baekgaard ,  Joanna Wawrzynczyk

IPC分类号： C12N9/42 ,  C12N9/20 ,  C12N9/88 ,  C12N9/48 ,  C12N9/26 ,  C12P5/02 ,  C12P7/08 ,  C12N9/50 ,  C12N9/24

CPC分类号： C11D3/38618 ,  C05F9/00 ,  C05F11/10 ,  C11D3/38627 ,  C11D3/38645 ,  C12N9/20 ,  C12N9/2411 ,  C12N9/2434 ,  C12N9/244 ,  C12N9/2448 ,  C12N9/2488 ,  C12N9/485 ,  C12N9/50 ,  C12N9/88 ,  C12P5/023 ,  C12P7/08 ,  C12Y301/01 ,  C12Y302/01 ,  C12Y302/01006 ,  C12Y302/01073 ,  C12Y304/11001 ,  C12Y304/21004 ,  C12Y304/23023 ,  C12Y304/23028 ,  Y02A40/214 ,  Y02E50/343

摘要： The present invention relates to a method for solubilisation or hydrolysis of Municipal Solid Waste (MSW) with an enzyme blend and an enzyme composition for solubilization of Municipal Solid Waste (MSW), the enzyme composition comprising a cellulolytic background composition and a protease, lipase and/or beta-glucanase.

公开(公告)号：US20170191046A1

公开(公告)日：2017-07-06

申请号：US15366370

申请日：2016-12-01

申请人： TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES

发明人： Rey-Ting Guo ,  Yingying Zheng ,  Zhongxia Xu ,  Chun-Chi Chen ,  Wei Peng ,  Weidong Liu ,  Je-Ruei Liu ,  Yanhe Ma

IPC分类号： C12N9/18 ,  A23K20/10

CPC分类号： C12N9/18 ,  A23K10/14 ,  A23K10/30 ,  A23K20/10 ,  A23L5/25 ,  C12Y301/01

摘要： A lactone hydrolase having improved activity towards α-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of SEQ ID NO: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading α-zearalenol using such lactone hydrolase is also disclosed.

公开(公告)号：US09670470B2

公开(公告)日：2017-06-06

申请号：US14777617

申请日：2014-03-21

申请人： Novozymes A/S

发明人： Kim Borch ,  Sara Landvik ,  Marianne Linde Damstrup ,  Jesper Brask

IPC分类号： C12N9/12 ,  C12P7/64 ,  C12N9/20 ,  C12N9/18 ,  C11B3/00

CPC分类号： C12N9/20 ,  C11B3/003 ,  C12N9/18 ,  C12Y301/01

摘要： The present invention relates to isolated polypeptides having phospholipase A activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

公开(公告)号：US20170079266A1

公开(公告)日：2017-03-23

申请号：US15267363

申请日：2016-09-16

申请人： Ecolab USA Inc.

发明人： Erik C. Olson ,  Carter M. Silvernail ,  Gregory G. Griese

IPC分类号： A01N33/04 ,  A61L2/23 ,  A01N25/12 ,  C10M141/06 ,  C11D3/30 ,  C11D3/386 ,  C11D3/20 ,  C11D17/00 ,  A01N25/30 ,  C11D3/48

CPC分类号： A01N33/04 ,  A01N25/12 ,  A01N25/30 ,  A61L2/23 ,  C07C209/68 ,  C07C211/14 ,  C10M105/00 ,  C10M105/26 ,  C10M105/30 ,  C10M141/06 ,  C10M2207/123 ,  C10M2207/1233 ,  C10M2207/124 ,  C10M2207/127 ,  C10M2207/1273 ,  C10M2207/142 ,  C10M2207/1423 ,  C10M2207/144 ,  C10M2207/1443 ,  C10M2215/04 ,  C10M2215/041 ,  C10N2250/08 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/30 ,  C11D3/38627 ,  C11D3/48 ,  C11D7/265 ,  C11D7/3209 ,  C11D17/0047 ,  C11D17/0052 ,  C12Y301/01

摘要： Stable, solid triamine compositions are disclosed. The pressed, cast, extruded or other solid compositions are suitable for antimicrobial, sanitizing and disinfectant applications. Ready-to-use solutions are obtained by dissolving the solid triamine compositions with water and the methods of use thereof are particularly suitable for cleaning, disinfecting, sanitizing, rinsing and/or lubricating. Beneficially, the solid triamine compositions are at least partially neutralized, allowing activity of 90% and greater of the biocidal triamine, and provide at least substantially similar or superior performance and micro efficacy to liquid formulations.

公开(公告)号：US20170015982A1

公开(公告)日：2017-01-19

申请号：US15121186

申请日：2015-03-10

申请人： NOVOZYMES A/S

发明人： Ming Li ,  tianqi Sun ,  Xianshi Jiang ,  Lone Baunsgaard ,  Carsten Hoerslev Hansen ,  Kim Borch ,  Han Bucong

IPC分类号： C12N9/20 ,  C11D11/00 ,  C11D3/386

CPC分类号： C12N9/20 ,  C11D3/38627 ,  C11D3/38681 ,  C11D11/0017 ,  C12Y301/01

摘要： Provided are isolated polypeptides with lipase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the polypeptides.

摘要翻译： 提供具有脂肪酶活性的分离的多肽和编码多肽的多核苷酸。 还提供了包含多核苷酸的核酸构建体，载体和宿主细胞，以及使用多肽的方法。