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公开(公告)号：US11958822B2
公开(公告)日：2024-04-16
申请号：US17965914
申请日：2022-10-14
申请人： CORSAIR PHARMA, INC.
发明人： Cyrus K. Becker , Meenakshi S. Venkatraman , Xiaoming Zhang , Jürg R. Pfister , Gwenaella Rescourio
IPC分类号： C07D321/00 , A61K9/00 , A61K9/70 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US11866402B2
公开(公告)日：2024-01-09
申请号：US17245235
申请日：2021-04-30
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/28 , C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07D307/30
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US11613702B2
公开(公告)日：2023-03-28
申请号：US16423730
申请日：2019-05-28
发明人： Noriyuki Hida , Haruki Okawa
IPC分类号： C09K19/34 , C09K19/38 , C09D133/14 , H01L51/00 , C08F20/18 , C07C67/08 , C07C69/74 , C09K19/20 , H01L27/32 , H01L51/52 , C09K19/04 , G02B5/30
摘要： A liquid crystal composition is provided containing a first liquid crystal compound represented by formula (1): and a second liquid crystal compound represented by formula (2): Also provided is a method for producing the liquid crystal composition having a desired wavelength dispersion characteristic.
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公开(公告)号：US11352312B2
公开(公告)日：2022-06-07
申请号：US16930578
申请日：2020-07-16
发明人： Naoki Ishibashi , Yusuke Nagae , Takeshi Kinsho
IPC分类号： C07C67/42 , C07C67/10 , C07C67/14 , C07C67/40 , C07C69/74 , C07C17/013 , C07C29/147 , C07C29/62
摘要： The present invention provides a process for preparing a diester compound of the following general formula (1), having a dimethylcyclobutane ring, wherein R1 and R2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 10 carbon atoms, the process comprising reacting a dimethylcyclobutanone compound of the following general formula (2), wherein R1 is as defined above, with a phosphonic ester compound of the following general formula (3), wherein R2 and R3 represent, independently of each other, a monovalent hydrocarbon group having 1 to 10 carbon atoms, to produce the diester compound (1), having a dimethylcyclobutane ring.
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公开(公告)号：US11034645B2
公开(公告)日：2021-06-15
申请号：US16574538
申请日：2019-09-18
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20210017115A1
公开(公告)日：2021-01-21
申请号：US16930578
申请日：2020-07-16
发明人： Naoki Ishibashi , Yusuke Nagae , Takeshi Kinsho
IPC分类号： C07C67/42 , C07C29/147 , C07C67/40 , C07C67/14 , C07C69/74 , C07C17/013 , C07C29/62 , C07C67/10
摘要： The present invention provides a process for preparing a diester compound of the following general formula (1), having a dimethylcyclobutane ring, wherein R1 and R2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 10 carbon atoms, the process comprising reacting a dimethylcyclobutanone compound of the following general formula (2), wherein R1 is as defined above, with a phosphonic ester compound of the following general formula (3), wherein R2 and R3 represent, independently of each other, a monovalent hydrocarbon group having 1 to 10 carbon atoms, to produce the diester compound (1), having a dimethylcyclobutane ring.
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公开(公告)号：US20200095230A1
公开(公告)日：2020-03-26
申请号：US16586401
申请日：2019-09-27
申请人： AbbVie Inc.
发明人： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC分类号： C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C69/74 , C07C43/196 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C67/08 , C07C68/02 , C07C211/35 , C12P1/00 , C12P41/00
摘要： The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20200071257A1
公开(公告)日：2020-03-05
申请号：US16574538
申请日：2019-09-18
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20200062726A1
公开(公告)日：2020-02-27
申请号：US16569840
申请日：2019-09-13
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , A61K9/70 , C07C69/96 , C07C69/74 , C07C59/72 , C07D295/145 , C07D211/60 , C07D295/088 , C07D207/08 , C07D265/30 , C07D263/26 , C07D263/24 , C07D257/06 , C07D453/02 , C07C219/16 , C07D317/40 , C07C69/712 , C07D317/34 , A61K9/00 , A61K45/06 , A61K31/341 , C07D307/20 , A61K31/365 , A61K31/216 , C07C69/734 , A61K31/165 , C07C235/20
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US20200039917A1
公开(公告)日：2020-02-06
申请号：US16601908
申请日：2019-10-15
申请人： XW Laboratories Inc.
发明人： Jia-Ning Xiang , Xuesong Xu , Xuan Zhang
IPC分类号： C07C69/78 , C07B59/00 , C07C69/76 , C07C69/24 , C07C229/36 , C07C69/608 , C07C317/44 , C07D277/56 , C07D211/46 , C07C69/738 , C07C69/28 , C07C255/57 , C07D213/79 , C07D213/80 , C07D309/12 , C07C271/22 , C07C271/34 , C07C69/612 , C07D317/64 , C07D333/38 , C07C229/08 , C07C233/47 , C07D207/16 , C07D307/68 , C07C69/22 , C07C69/34 , C07C69/618 , C07C69/74 , C07C69/96 , C07C229/34 , C07C317/14 , C07D207/12 , C07D211/44 , C07D277/30
摘要： The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
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