Sample clean up method
    2.
    发明授权

    公开(公告)号:US12214296B2

    公开(公告)日:2025-02-04

    申请号:US18165246

    申请日:2023-02-06

    Applicant: Biotage AB

    Abstract: The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

    Chromatography system
    3.
    发明授权

    公开(公告)号:US12188911B2

    公开(公告)日:2025-01-07

    申请号:US17602701

    申请日:2020-04-16

    Abstract: A chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters and to further provide guidance to the user. The system has a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in the column, to calculate the efficiency of the column.

    Method and apparatus for the production of high purity radionuclides

    公开(公告)号:US12183475B2

    公开(公告)日:2024-12-31

    申请号:US17087838

    申请日:2020-11-03

    Applicant: Orano Med

    Abstract: An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A1′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A2 washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A2′ washing solution from a solution inlet through the chromatography column from the tail port to the head port.

    Method and Apparatus for Packing a Chromatography Column Assembly

    公开(公告)号:US20240402142A1

    公开(公告)日:2024-12-05

    申请号:US18748622

    申请日:2024-06-20

    Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube having a closed first end comprising an inlet/outlet, a media inlet adjacent a second end of the column tube and an adaptor positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.

    INTERCHANGEABLE CHROMATOGRAPHY CARTRIDGE ADAPTER SYSTEM

    公开(公告)号:US20240261704A1

    公开(公告)日:2024-08-08

    申请号:US18623582

    申请日:2024-04-01

    CPC classification number: B01D15/22 B01D15/20 B01D53/025 B01D2256/22

    Abstract: A chromatography system has a cartridge adapter that is detachably attachable to enable a chromatography cartridge to be quickly interchanged. Chromatography cartridges are configured with threads for coupling to a corresponding interchangeable coupling component having matching threads. The interchangeable coupling component may be secured to the chromatography system by a coupling retainer. A coupling retainer may have a keyway that is configured for quick interchanging of the interchangeable coupling components. The interchangeable coupling component may have a pair of parallel sides that align with a slot of the keyway to secure the interchangeable coupling components to the coupling retainer. An inlet nipple of the chromatography cartridge may extend through an opening in the coupling components and couple to an inlet conduit for sample gas. Analyte gas may flow back to the chromatography system for detection and collection.

    DATA PROCESSING METHOD AND DEVICE FOR CHROMATOGRAM, CHROMATOGRAPHIC DEVICE, AND RECORDING MEDIUM

    公开(公告)号:US20240210366A1

    公开(公告)日:2024-06-27

    申请号:US18540375

    申请日:2023-12-14

    CPC classification number: G01N30/8631 B01D15/203

    Abstract: Disclosed is a method for identifying the accurate number of peaks which includes a peak extraction process of extracting a number of target peaks corresponding to a number of target components to be identified, among the multiple components from a group of peaks appearing on the chromatogram, a peak identification process that assigns names of the target components to the target peaks in descending or ascending order of first retention time, based on a standard sample timetable preloaded with a relationship between the names of the target components and the corresponding first retention times, which are retention times of the target components, is stored, and a standard sample timetable updating process that updates the first retention times in the standard sample timetable, with second retention times that are measured retention times of the target peaks.

Patent Agency Ranking