公开(公告)号：US11022350B2

公开(公告)日：2021-06-01

申请号：US16384117

申请日：2019-04-15

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Chinedu David Chikwem ,  Daniel Alan Brisach ,  Kim Ferrera ,  Curtis Ebersold

IPC: F25B25/00 ,  F25B9/00 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  F25B7/00 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/04 ,  F25B9/10 ,  G01N30/20

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

公开(公告)号：US20180112896A1

公开(公告)日：2018-04-26

申请号：US15784131

申请日：2017-10-14

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Chinedu David Chikwem ,  Daniel Alan Brisach ,  Kim Ferrara ,  Curtis B. Ebersold

IPC: F25B25/00 ,  B01D15/40 ,  B01D15/16 ,  B04C9/00 ,  B04C5/081 ,  B04C5/085 ,  F25B9/00 ,  F25B9/10 ,  C09K5/04 ,  C07C45/79 ,  C07C67/56 ,  C07C51/47 ,  C07C231/24

CPC classification number: F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  B04C2009/004 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54 ,  Y02P20/544

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off the shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

公开(公告)号：US12036566B2

公开(公告)日：2024-07-16

申请号：US18485807

申请日：2023-10-12

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Andrew Cloud ,  Kenneth Richard Krewson ,  Kenneth Joseph James

IPC: B01D45/12 ,  B04C5/04 ,  B04C5/081 ,  B04C5/103 ,  B01D15/24 ,  B01D15/40 ,  G01N30/84

CPC classification number: B04C5/081 ,  B01D45/12 ,  B04C5/04 ,  B04C5/103 ,  B01D15/24 ,  B01D15/40 ,  G01N30/84

Abstract: A gas-liquid separator system that can effectively and efficiently separate liquid from a streaming mixture having a liquid portion and a gas portion. The gas-liquid separator may be used in supercritical fluid chromatography application where an analyte is separated from a carrier gas, such as carbon dioxide. A streaming mixture is dispensed into a separation chamber formed by a spindle shaft configured inside of a shroud cavity. The shroud cavity has a plurality of concave channels along the inner surface and extend down to an outlet end. The concave channels create pressure variations that promote the liquid portion to condense onto the inner surface of the shroud and flow down to the exhaust port. A spherical collection portion is configured on the outlet of the shroud and the condensed liquid flows thereover and down along a cone portion and off the cone tip.

公开(公告)号：US11946915B2

公开(公告)日：2024-04-02

申请号：US17416964

申请日：2020-01-03

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Curtis Ebersold ,  Kim Ferrara

IPC: G01N30/60 ,  B01D15/20 ,  B01D15/22

CPC classification number: G01N30/6091 ,  B01D15/20 ,  B01D15/22 ,  B01D2256/22

Abstract: A chromatography system has a cartridge adapter that is detachably attachable to enable a chromatography cartridge to be quickly interchanged. Chromatography cartridges are configured with threads for coupling to a corresponding interchangeable coupling component having matching threads. The interchangeable coupling component may be secured to the chromatography system by a coupling retainer. A coupling retainer may have a keyway that is configured for quick interchanging of the interchangeable coupling components. The interchangeable coupling component may have a pair of parallel sides that align with a slot of the keyway to secure the interchangeable coupling components to the coupling retainer. An inlet nipple of the chromatography cartridge may extend through an opening in the coupling components and couple to an inlet conduit for sample gas. Analyte gas may flow back to the chromatography system for detection and collection.

公开(公告)号：US11680735B2

公开(公告)日：2023-06-20

申请号：US17313189

申请日：2021-05-06

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Kim Ferrara ,  Curtis Ebersold

IPC: F25B7/00 ,  F25B9/00 ,  F25B9/10 ,  F25B25/00 ,  F25B49/02 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/04

CPC classification number: F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  B04C2009/004 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  Y02P20/54

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

公开(公告)号：US20200056815A1

公开(公告)日：2020-02-20

申请号：US16384117

申请日：2019-04-15

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Chinedu David Chikwem ,  Daniel Alan Brisach ,  Kim Ferrera ,  Curtis Ebersold

IPC: F25B25/00 ,  F25B7/00 ,  G01N30/54 ,  G01N30/30 ,  F25B49/02 ,  F25B9/00 ,  F25B9/10 ,  C09K5/04 ,  C07C231/24 ,  C07C67/56 ,  C07C51/47 ,  C07C45/79 ,  B04C9/00 ,  B04C5/085 ,  B04C5/081 ,  B01D15/40 ,  B01D15/16

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

公开(公告)号：US20170246558A1

公开(公告)日：2017-08-31

申请号：US15504313

申请日：2015-08-07

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph JAMES ,  Brian Jeffrey WAIBEL ,  Kenneth Richard KREWSON ,  Christopher Joseph McWILLIAMS ,  Chinedu David CHIKWEM ,  Daniel Alan BRISACH

IPC: B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B01D15/16 ,  F25B9/10 ,  C09K5/04 ,  G01N30/30 ,  G01N30/32 ,  C07C45/79 ,  C07C67/56 ,  C07C231/24 ,  C07C51/47 ,  B04C9/00 ,  F25B9/00

CPC classification number: B01D15/40 ,  B01D11/0203 ,  B01D11/0403 ,  B01D15/165 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  B04C2009/004 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  F25B7/00 ,  F25B9/002 ,  F25B9/10 ,  F25B25/005 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/027 ,  Y02P20/544

Abstract: Provided is a supercritical fluid chromatography system, and components comprising such a system, including one or more of a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel, and a supercritical fluid cyclonic separator. The supercritical fluid chiller and the use of the chiller allow efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps in the supercritical chromatography system using liquid-phase gas mobile phase. The pressure equalizing vessel allows the use of off the shelf HPLC column cartridges in the supercritical chromatography system. The cyclonic separator efficiently and effectively allows for separation of sample molecules from a liquid phase or gas phase stream of a supercritical fluid.

公开(公告)号：US11913685B2

公开(公告)日：2024-02-27

申请号：US17506353

申请日：2021-10-20

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Kim Ferrara ,  Curtis Ebersold

IPC: F25B7/00 ,  F25B9/00 ,  F25B9/10 ,  F25B25/00 ,  F25B49/02 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  C07C45/79 ,  C07C51/47 ,  C07C231/24 ,  C09K5/04 ,  B04C9/00 ,  C07C67/56

CPC classification number: F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  B04C2009/004 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  Y02P20/54

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

公开(公告)号：US20240261704A1

公开(公告)日：2024-08-08

申请号：US18623582

申请日：2024-04-01

Applicant: SUPERCRITICAL FLUID TECHNOLOGIES, INC.

Inventor： Kenneth Richard Krewson ,  Andrew Cloud ,  Kenneth Joseph James ,  Curtis EBERSOLD ,  Kim FERRARA

IPC: B01D15/22 ,  B01D15/20 ,  B01D53/02

CPC classification number: B01D15/22 ,  B01D15/20 ,  B01D53/025 ,  B01D2256/22

Abstract: A chromatography system has a cartridge adapter that is detachably attachable to enable a chromatography cartridge to be quickly interchanged. Chromatography cartridges are configured with threads for coupling to a corresponding interchangeable coupling component having matching threads. The interchangeable coupling component may be secured to the chromatography system by a coupling retainer. A coupling retainer may have a keyway that is configured for quick interchanging of the interchangeable coupling components. The interchangeable coupling component may have a pair of parallel sides that align with a slot of the keyway to secure the interchangeable coupling components to the coupling retainer. An inlet nipple of the chromatography cartridge may extend through an opening in the coupling components and couple to an inlet conduit for sample gas. Analyte gas may flow back to the chromatography system for detection and collection.

公开(公告)号：US20240247843A1

公开(公告)日：2024-07-25

申请号：US18586850

申请日：2024-02-26

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Kim Ferrara ,  Curtis Ebersold

IPC: F25B25/00 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/04 ,  F25B7/00 ,  F25B9/00 ,  F25B9/10 ,  F25B49/02 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54

CPC classification number: F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  B04C2009/004 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  Y02P20/54

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.