-
公开(公告)号：US11872410B2
公开(公告)日：2024-01-16
申请号：US17702157
申请日：2022-03-23
申请人： QSA GLOBAL, INC.
发明人： Mark G. Shilton , Mark W. Vose , Jason W. Bourn
CPC分类号： A61N5/1017 , A61K51/025 , A61K51/1282 , G21G4/08 , A61F9/0017 , A61N2005/1024 , A61N2005/1089 , A61N2005/1094
摘要： The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a radiological insert within an encapsulation. The encapsulation may include increased shielding in the center thereof.
-
公开(公告)号：US20230395276A1
公开(公告)日：2023-12-07
申请号：US18203979
申请日：2023-05-31
CPC分类号： G21G1/001 , G21G4/08 , G21G2001/0042
摘要： A generator column assembly for the elution of a radioisotope, having a generator column container having a bottom wall defining a flow outlet aperture, an open top end, and a sidewall extending from the open top end to the bottom wall that defines an interior volume having a substantially cylindrical upper volume portion and a substantially cylindrical lower volume portion, the upper volume portion having a diameter that is greater than a diameter of the lower volume portion, and a closure cap assembly including a substantially cylindrical container cap defining a flow inlet aperture, the container cap being configured to be slidably received in the open top end of the generator column container.
-
公开(公告)号：US11532406B2
公开(公告)日：2022-12-20
申请号：US16095865
申请日：2017-04-24
发明人： Timothy R. DeGrado , Huailei Jiang
摘要： Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.
-
公开(公告)号：US11464896B2
公开(公告)日：2022-10-11
申请号：US16422513
申请日：2019-05-24
发明人： Stephen E. Hidem , Aaron M. Fontaine , Janet L. Gelbach , Patrick M. McDonald , Kathryn M. Hunter , Rolf E. Swenson , Julius P. Zodda , Kimberly J. McDaniel
IPC分类号： A61M5/00 , A61N5/10 , A61M5/142 , G21G4/08 , A61B90/00 , A61M5/14 , G21F7/00 , G21G1/00 , A61B6/03 , A61B6/00 , G16Z99/00 , A61B6/10 , G21F3/00 , A61K51/00 , A61M5/168 , A61B50/13 , A61M5/145 , A61M5/158 , G06F21/31 , A61M5/36 , G16H20/17 , A61B50/10 , B62B3/00
摘要： Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
-
公开(公告)号：US20210265069A1
公开(公告)日：2021-08-26
申请号：US16799127
申请日：2020-02-24
摘要： The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
-
公开(公告)号：US11037690B2
公开(公告)日：2021-06-15
申请号：US16000615
申请日：2018-06-05
申请人： ORANO MED
IPC分类号： G21G1/00 , G01N30/84 , G01D15/12 , G01N30/06 , B01D15/42 , A61K51/12 , C22B13/02 , C22B13/06 , C22C11/00 , B01D15/12 , G21G4/08
摘要： The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
-
公开(公告)号：US20210050126A1
公开(公告)日：2021-02-18
申请号：US17087838
申请日：2020-11-03
申请人： Orano Med
摘要： An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A1′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A2 washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A2′ washing solution from a solution inlet through the chromatography column from the tail port to the head port.
-
公开(公告)号：US20200306393A1
公开(公告)日：2020-10-01
申请号：US16832412
申请日：2020-03-27
发明人： Riccardo SANTOPIETRO , Robert William RIDDOCH , Paul DONNELLY , Etienne LEFORT , Cristian-Leonardo JUVERDIANU
摘要： A radioisotope elution system is provided, that has at least a component comprised in a cabinet and accessible via a door equipped with an authentication system to ensure safety. The system may also have a user interface equipped with an authentication system. It is also provided a radioisotope elution system that has a dose calibrator equipped with a lifting mechanism for lifting and/or lowering the vial to be tested in the dose calibrator. Advantageously, the lifting mechanism may be controlled for preventing the vial from being lifted during a quality control test on a sample of eluate in the vial. This feature prevents a user from tampering and/or interfering with the vial while a quality control testing is in progress. In another feature, there is provided a radioisotope elution system with a scanning system for entering information about the radioisotope generator and/or the patient in the system. Systems ensuring that the eluant reservoir contains a saline solution are proposed.
-
公开(公告)号：US20200066418A1
公开(公告)日：2020-02-27
申请号：US16113817
申请日：2018-08-27
发明人： David A. Rotsch , Nicholas A. Smith , David A. Ehst , Sergey A. Chemerisov , Jerry A. Nolen, JR. , Michael Alexander Brown , James J. Grudzinski , James L. Bailey , Ronald T. Kmak
摘要： A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.
-
公开(公告)号：US20200027621A1
公开(公告)日：2020-01-23
申请号：US16444371
申请日：2019-06-18
申请人： QSA GLOBAL INC.
发明人： Mark SHILTON
摘要： The disclosure pertains to improvements in a gamma radiation source, typically containing low-density alloys or compounds or composites of iridium in mechanically deformable and compressible configurations, within a sealed encapsulation, and methods of manufacture thereof.
-
-
-
-
-
-
-
-
-
搜索结果
316 条记录 (耗时 0.023 秒)
