An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A1′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A2 washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A2′ washing solution from a solution inlet through the chromatography column from the tail port to the head port.