公开(公告)号：US20220031871A1

公开(公告)日：2022-02-03

申请号：US17048072

申请日：2019-04-16

申请人： Hoffmann-La Roche Inc. ,  Orano Med SAS

发明人： Julien TORGUE ,  Paul JUREK ,  Federico ROJAS-QUIJANO ,  Garry E. KIEFER ,  Olivier FREYTAG ,  Christian GERDES ,  Christian KLEIN ,  Pablo UMANA ,  Alexander HAAS ,  Sofia FROST ,  Amal SAIDI ,  Tapan NAYAK

IPC分类号： A61K51/04 ,  A61K51/06 ,  A61K51/10 ,  A61P35/00

摘要： The present application relates to antibodies which bind specifically to chelated radionuclides, including bispecific antibodies, It further relates to the use of such bispecific antibodies in applications such as radioimmunoimaging and radioimmunotherapy. It additionally relates to clearing agents and useful in such methods.

公开(公告)号：US20210050126A1

公开(公告)日：2021-02-18

申请号：US17087838

申请日：2020-11-03

申请人： Orano Med

发明人： Julien TORGUE ,  Patrick BOURDET ,  Gilbert ANDREOLETTI ,  Rémy DUREAU ,  Patrick MAQUAIRE

IPC分类号： G21G1/00 ,  B01D15/20 ,  B01D15/36 ,  B01D15/42 ,  C22B60/02 ,  G21G4/08

摘要： An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A1′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A2 washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A2′ washing solution from a solution inlet through the chromatography column from the tail port to the head port.

公开(公告)号：US20230120220A1

公开(公告)日：2023-04-20

申请号：US17798879

申请日：2021-02-11

申请人： Orano Med

发明人： Tania A. STALLONS ,  Julien TORGUE ,  Garry E. KIEFER ,  Federico ROJAS-QUIJANO

IPC分类号： A61K51/10 ,  A61K47/65

摘要： A process is for preparing a site-specific bioconjugated antibody of a formula (I): Ab-(Linker-Chelator)n (I). The Linker is an oligopeptide with an N-terminal end. The Chelator is a metal chelating agent. n is a Chelator-to antibody ratio (CAR), wherein 0

公开(公告)号：US20180350480A1

公开(公告)日：2018-12-06

申请号：US15778397

申请日：2016-11-22

申请人： Orano Med

发明人： Julien TORGUE ,  Patrick BOURDET ,  Gilbert ANDREOLETTI ,  Rémy DUREAU ,  Patrick MAQUAIRE

IPC分类号： G21G1/00 ,  B01D15/20 ,  G21G4/08 ,  C22B60/02 ,  B01D15/36 ,  B01D15/42

CPC分类号： G21G1/0005 ,  G21G2001/0094

摘要： The present invention concerns a process for producing a daughter radionuclide from a parent radionuclide comprising the purification of the daughter radionuclide on a chromatography column, as well as the apparatus for carrying out such process.