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公开(公告)号：US11534506B2
公开(公告)日：2022-12-27
申请号：US15555775
申请日：2016-03-07
摘要： Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.
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公开(公告)号：US11532406B2
公开(公告)日：2022-12-20
申请号：US16095865
申请日：2017-04-24
发明人： Timothy R. DeGrado , Huailei Jiang
摘要： Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.
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公开(公告)号：US20200306188A1
公开(公告)日：2020-10-01
申请号：US16834048
申请日：2020-03-30
摘要： A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of poly(ethylene glycol), or a derivative of phenothiazine. The EVs are homed to the homing agent in the subject.
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公开(公告)号：US20210330823A1
公开(公告)日：2021-10-28
申请号：US17358544
申请日：2021-06-25
摘要： Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.
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公开(公告)号：US20210225547A1
公开(公告)日：2021-07-22
申请号：US16095865
申请日：2017-04-24
发明人： Timothy R. DeGrado , Huailei Jiang
摘要： Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.
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公开(公告)号：US20200020457A1
公开(公告)日：2020-01-16
申请号：US16565125
申请日：2019-09-09
发明人： Timothy R. DeGrado , Mukesh K. Pandey , John Byrne
摘要： Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
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公开(公告)号：US20190198187A1
公开(公告)日：2019-06-27
申请号：US16328171
申请日：2017-08-28
CPC分类号： G21G1/001 , A61K51/06 , C01G9/00 , C01G15/00 , C01P2006/44 , C07B59/00 , G21G1/10 , G21G4/08 , G21G2001/0021 , G21G2001/0094
摘要： Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.
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公开(公告)号：US20180043041A1
公开(公告)日：2018-02-15
申请号：US15555775
申请日：2016-03-07
CPC分类号： A61K51/0478 , A61K49/103 , A61K49/106 , A61K49/1896 , A61K51/1203
摘要： Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.
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公开(公告)号：US20170301427A1
公开(公告)日：2017-10-19
申请号：US15493310
申请日：2017-04-21
发明人： Timothy R. DeGrado , Mukesh K. Pandey , John Byrne
CPC分类号： G21G1/10 , B01D15/08 , G21G1/001 , G21G2001/0021 , H05H6/00
摘要： Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
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公开(公告)号：US11510876B2
公开(公告)日：2022-11-29
申请号：US16834048
申请日：2020-03-30
摘要： A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of poly(ethylene glycol), or a derivative of phenothiazine. The EVs are homed to the homing agent in the subject.
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