公开(公告)号：US20250027158A1

公开(公告)日：2025-01-23

申请号：US18744995

申请日：2024-06-17

Applicant: Exact Sciences Corporation ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC: C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6886 ,  G01N33/533 ,  G01N33/574 ,  G16Z99/00

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

公开(公告)号：US20250025501A1

公开(公告)日：2025-01-23

申请号：US18709445

申请日：2022-11-14

Applicant: IMANIS LIFE SCIENCES, LLC ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  FIOS THERAPEUTICS LLC

Inventor： Stephen J. Russell ,  Karina Krotova ,  Christopher G.A. McGregor

IPC: A61K35/17 ,  A61K35/766 ,  A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/86

Abstract: Provided herein are genetically modified ungulate cells expressing a chimeric antigen receptor. Also provided herein are transgenic ungulate cells that can be used as cell carriers for the delivery of oncolytic viruses in cancer therapy. Also provided are transgenic ungulates comprising these cells, methods of making these cells, and methods of treating cancer by administering these cells to a subject in need thereof. Also provided are transgenic ungulate cells that express a chimeric antigen receptor and uses thereof.

公开(公告)号：US20250025196A1

公开(公告)日：2025-01-23

申请号：US18906681

申请日：2024-10-04

Applicant: Mayo Foundation for Medical Education and Research

Inventor： DARRYL E. BARNES ,  JAY SMITH

IPC: A61B17/32 ,  A61B17/22 ,  A61B17/30 ,  A61B90/00 ,  A61M25/10

Abstract: Some embodiments provide a soft tissue device, such as a transverse carpal ligament cutting device having one or more balloons that are deflated when the device is in an inactive position and are inflated when the device is in an active position. Other embodiments provide a soft tissue cutting method, such as a method of cutting a transverse carpal ligament that uses a soft tissue cutting device.

公开(公告)号：US20250025114A1

公开(公告)日：2025-01-23

申请号：US18710059

申请日：2022-11-15

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Scott S. Hsieh

IPC: A61B6/03 ,  A61B6/00 ,  G21K1/02

Abstract: A method for acquiring x-ray data from a subject and generating a computed tomography (CT) image of the subject includes receiving a set of illumination field data including an illumination field produced by each of a plurality of focal spot positions of an x-ray source, selecting at least one sequence of at least two illumination fields based on at least one subject-specific parameter, assigning an illumination field from the selected at least one sequence to each gantry rotation angle in a plurality of gantry rotation angles, acquiring x-ray data from a subject for each gantry rotation angle using a focal spot position associated with the illumination field that is assigned to the gantry rotation angle, and generating an image slice based on the acquired x-ray data for each of the plurality of gantry rotation angles. The x-ray data can include a number of photons received by the detector array.

公开(公告)号：US20250009797A1

公开(公告)日：2025-01-09

申请号：US18707326

申请日：2022-11-04

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Richard G. Vile ,  Rosa M. Diaz Marcano ,  Timothy J. Kottke ,  Jason M. Tonne

IPC: A61K35/17 ,  A61K39/00 ,  C07K14/725 ,  C12N15/86

Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using (a) APCs (e.g., dendritic cells) designed to release a viral vector that can infect a T cell (e.g., an infectious retroviral vector or an infectious lentiviral vector) and drive expression of an antigen receptor (e.g., a CAR) within that T cell and (b) an antigenic composition containing one or more antigens that can be presented to T cells within the mammal by APCs of the administered population and/or by other APCs within the mammal to produce dual specific CAR+ memory T cells are provided.

公开(公告)号：US12185992B2

公开(公告)日：2025-01-07

申请号：US17297947

申请日：2019-12-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Christine Mehner ,  Marion T. Turnbull

IPC: A61B17/72 ,  A61B17/88 ,  A61B17/90 ,  A61B17/68

Abstract: Intramedullary nails can be used for the treatment of a bone fracture. In some embodiments, such intramedullary nails can include an elongate shaft having a longitudinal axis, a distal nail component, and a proximal nail component. In some embodiments, the intramedullary nails include a first rotatable shaft and a second rotatable shaft. In some embodiments, the intramedullary nails include a handle coupled to the first and second rotatable shafts.

公开(公告)号：US20240424492A1

公开(公告)日：2024-12-26

申请号：US18826364

申请日：2024-09-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Alan M. Gonzalez Suarez ,  Alexander Revzin

IPC: B01L3/00 ,  G01N33/49 ,  G01N33/66

Abstract: This document provides methods, devices, and systems for detecting the presence, absence, or amount of two or more analytes present within a small volume (e.g., less than 10 μL) of a sample (e.g., a blood sample) obtained from a mammal (e.g., a human such as a human neonate). For example, methods and materials for using plasma separation and multiplex analyte detection to detect two or more analytes (e.g., proteins, carbohydrates, lipids, nucleic acids, intact cells, intact viruses, intact microorganisms, and/or chemicals) within a small volume of a blood sample are provided.

公开(公告)号：US20240416117A1

公开(公告)日：2024-12-19

申请号：US18659672

申请日：2024-05-09

Applicant: Mayo Foundation for Medical Education and Research ,  Regents of the University of Minnesota

Inventor： Hai-Long Wang ,  Gregory A. Worrell ,  Vanda A. Lennon ,  Haidong Dong ,  Lynne T. Bemis ,  Richard G. Melvin

IPC: A61N1/36 ,  A61K9/00 ,  A61K31/7105 ,  A61K31/713 ,  A61N2/00

Abstract: Methods for modulating the release and content of extracellular vesicles from target cells using electrical stimulation are provided. Compositions comprising extracellular vesicles or extracts of extracellular vesicles and methods of administering the compositions to a subject are also provided.

公开(公告)号：US12161868B2

公开(公告)日：2024-12-10

申请号：US17577724

申请日：2022-01-18

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Samuel J. Asirvatham

IPC: A61N1/36 ,  A61N1/04 ,  G16H40/67

Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.

公开(公告)号：US12156312B2

公开(公告)日：2024-11-26

申请号：US17335443

申请日：2021-06-01

Applicant: Gentex Corporation ,  Mayo Foundation for Medical Education and Research

Inventor： Jason D. Hallack ,  Bradley R. Hamlin ,  David M. Falb ,  Jeremy A. Schut ,  Danny L Minikey, Jr. ,  Mark A VanVuuren ,  David J. Wright

IPC: H05B47/125 ,  A61B90/00 ,  A61B90/35 ,  G06V10/141 ,  G06V10/24 ,  H04N23/61 ,  H04N23/74

Abstract: A method for controlling an illumination system includes detecting a first position of a marker in image data. In response to the first position, a first light target for the first light emission is identified. Controlling a light assembly to direct the first light emission to the first light target and maintaining the first light emission directed to the first light target. The method further includes detecting a second position of the marker in the image data. A second light target for the second light emission is identified in response to the second position. The light assembly is controlled to direct the second light emission to the second light target.