公开(公告)号：US20250025501A1

公开(公告)日：2025-01-23

申请号：US18709445

申请日：2022-11-14

Applicant: IMANIS LIFE SCIENCES, LLC ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  FIOS THERAPEUTICS LLC

Inventor： Stephen J. Russell ,  Karina Krotova ,  Christopher G.A. McGregor

IPC: A61K35/17 ,  A61K35/766 ,  A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/86

Abstract: Provided herein are genetically modified ungulate cells expressing a chimeric antigen receptor. Also provided herein are transgenic ungulate cells that can be used as cell carriers for the delivery of oncolytic viruses in cancer therapy. Also provided are transgenic ungulates comprising these cells, methods of making these cells, and methods of treating cancer by administering these cells to a subject in need thereof. Also provided are transgenic ungulate cells that express a chimeric antigen receptor and uses thereof.