公开(公告)号：US10183237B2

公开(公告)日：2019-01-22

申请号：US15127649

申请日：2015-03-20

Applicant: BIOTAGE AB

Inventor： Sunil Rana ,  Steve Jordan ,  Geoff Davies

IPC: B01D15/20 ,  B01D15/16 ,  G01N30/36 ,  G01N30/54 ,  G01N30/72 ,  G01N30/34

Abstract: Disclosed is a method for equilibrating a chromatography column including the steps of (i) providing a mobile phase; and (ii) passing the mobile phase through a packed chromatography column; wherein the mobile phase includes two liquids, the proportions of which change as it is passed through the column. Also discussed are automated aspects of the method, as well as a system capable of performing such method.

公开(公告)号：US20150136681A1

公开(公告)日：2015-05-21

申请号：US14409410

申请日：2013-06-05

Applicant: Biotage AB

Inventor： Steve Jordan ,  Geoff Davies ,  Sunil Rana

IPC: B01D29/33 ,  B01D29/52 ,  B01D17/02

CPC classification number: B01D29/336 ,  B01D11/0415 ,  B01D17/02 ,  B01D17/085 ,  B01D29/52 ,  B01D69/046 ,  B01D71/26 ,  B01D71/36 ,  B01D2313/025 ,  B01D2313/04 ,  B01D2325/38

Abstract: The present invention relates to a phase separation element and a phase separation device comprising such a phase separation element, which may be used for separating a biphasic aqueous and organic liquid system irrespective of which liquid is heavier.

Abstract translation: 本发明涉及一种相分离元件和包括这种相分离元件的相分离装置，其可用于分离双相水和有机液体系统，而不管哪种液体较重。

公开(公告)号：US12214296B2

公开(公告)日：2025-02-04

申请号：US18165246

申请日：2023-02-06

Applicant: Biotage AB

Inventor： Geoff Davies ,  Adam Senior ,  Lee Williams ,  Rhys Jones

IPC: B01D15/12 ,  B01D15/20 ,  B01J20/04 ,  B01J20/08 ,  B01J20/10 ,  B01J20/281 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01L3/02 ,  G01N1/40 ,  G01N30/52 ,  G01N30/60

Abstract: The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

公开(公告)号：US11617968B2

公开(公告)日：2023-04-04

申请号：US16642474

申请日：2018-10-17

Applicant: Biotage AB

Inventor： Geoff Davies ,  Adam Senior ,  Lee Williams ,  Rhys Jones

IPC: B01D15/12 ,  B01D15/20 ,  B01J20/04 ,  B01J20/08 ,  B01J20/10 ,  B01J20/281 ,  G01N30/52 ,  G01N30/60 ,  B01L3/02 ,  G01N1/40

Abstract: The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.